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Protein

Prefoldin subunit 3

Gene

VBP1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 3
Alternative name(s):
Von Hippel-Lindau-binding protein 1
Short name:
VBP-1
Short name:
VHL-binding protein 1
Gene namesi
Name:VBP1
Synonyms:PFDN3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome X

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: In complex with VHL can translocate to the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 197196Prefoldin subunit 3PRO_0000153654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei59 – 591N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ5RCG9.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000023400.

Structurei

3D structure databases

ProteinModelPortaliQ5RCG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiKOG3313. Eukaryota.
ENOG410XRZ8. LUCA.
GeneTreeiENSGT00390000018904.
HOVERGENiHBG053576.
InParanoidiQ5RCG9.
OMAiDEQHSKY.
OrthoDBiEOG7V4B10.
TreeFamiTF313706.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR016655. PFD3.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PANTHERiPTHR12409. PTHR12409. 1 hit.
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
PIRSFiPIRSF016396. Prefoldin_subunit_3. 1 hit.
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RCG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVKDSCGK GEMATGNGRR LHLGIPEAVF VEDVDSFMKQ PGNETADTVL
60 70 80 90 100
KKLDEQYQKY KFMELNLAQK KRRLKGQIPE IKQTLEILKY MQKKKESTNS
110 120 130 140 150
METRFLLADN LYCKASVPPT DKVCLWLGAN VMLEYDIDEA QALLEKNLST
160 170 180 190
ATKNLDSLEE DLDFLRDQFT TTEVNMARVY NWDVKRRNKD DSTKNKA
Length:197
Mass (Da):22,626
Last modified:December 21, 2004 - v1
Checksum:i973BA048048D948E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858301 mRNA. Translation: CAH90538.1.
RefSeqiNP_001129019.1. NM_001135547.1.
UniGeneiPab.19814.

Genome annotation databases

EnsembliENSPPYT00000024378; ENSPPYP00000023400; ENSPPYG00000020900.
GeneIDi100190860.
KEGGipon:100190860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858301 mRNA. Translation: CAH90538.1.
RefSeqiNP_001129019.1. NM_001135547.1.
UniGeneiPab.19814.

3D structure databases

ProteinModelPortaliQ5RCG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000023400.

Proteomic databases

PRIDEiQ5RCG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000024378; ENSPPYP00000023400; ENSPPYG00000020900.
GeneIDi100190860.
KEGGipon:100190860.

Organism-specific databases

CTDi7411.

Phylogenomic databases

eggNOGiKOG3313. Eukaryota.
ENOG410XRZ8. LUCA.
GeneTreeiENSGT00390000018904.
HOVERGENiHBG053576.
InParanoidiQ5RCG9.
OMAiDEQHSKY.
OrthoDBiEOG7V4B10.
TreeFamiTF313706.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR016655. PFD3.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PANTHERiPTHR12409. PTHR12409. 1 hit.
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
PIRSFiPIRSF016396. Prefoldin_subunit_3. 1 hit.
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPFD3_PONAB
AccessioniPrimary (citable) accession number: Q5RCG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.