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Protein

Prefoldin subunit 3

Gene

VBP1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 3
Alternative name(s):
von Hippel-Lindau-binding protein 1
Short name:
VBP-1
Short name:
VHL-binding protein 1
Gene namesi
Name:VBP1
Synonyms:PFDN3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome X

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001536542 – 197Prefoldin subunit 3Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei59N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ5RCG9

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000023400

Structurei

3D structure databases

ProteinModelPortaliQ5RCG9
SMRiQ5RCG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiKOG3313 Eukaryota
ENOG410XRZ8 LUCA
GeneTreeiENSGT00390000018904
HOVERGENiHBG053576
InParanoidiQ5RCG9
OMAiQITVMEV
OrthoDBiEOG091G0P5N
TreeFamiTF313706

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR016655 PFD3
IPR009053 Prefoldin
IPR004127 Prefoldin_subunit_alpha
PANTHERiPTHR12409 PTHR12409, 1 hit
PfamiView protein in Pfam
PF02996 Prefoldin, 1 hit
PIRSFiPIRSF016396 Prefoldin_subunit_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RCG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVKDSCGK GEMATGNGRR LHLGIPEAVF VEDVDSFMKQ PGNETADTVL
60 70 80 90 100
KKLDEQYQKY KFMELNLAQK KRRLKGQIPE IKQTLEILKY MQKKKESTNS
110 120 130 140 150
METRFLLADN LYCKASVPPT DKVCLWLGAN VMLEYDIDEA QALLEKNLST
160 170 180 190
ATKNLDSLEE DLDFLRDQFT TTEVNMARVY NWDVKRRNKD DSTKNKA
Length:197
Mass (Da):22,626
Last modified:December 21, 2004 - v1
Checksum:i973BA048048D948E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858301 mRNA Translation: CAH90538.1
RefSeqiNP_001129019.1, NM_001135547.1
UniGeneiPab.19814

Genome annotation databases

EnsembliENSPPYT00000024378; ENSPPYP00000023400; ENSPPYG00000020900
GeneIDi100190860
KEGGipon:100190860

Similar proteinsi

Entry informationi

Entry nameiPFD3_PONAB
AccessioniPrimary (citable) accession number: Q5RCG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health