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Q5RCE0

- GPDA_PONAB

UniProt

Q5RCE0 - GPDA_PONAB

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Gene

GPD1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411NADBy similarity
Binding sitei97 – 971NADBy similarity
Binding sitei120 – 1201SubstrateBy similarity
Binding sitei153 – 1531NAD; via amide nitrogenBy similarity
Active sitei204 – 2041Proton acceptorSequence Analysis
Binding sitei269 – 2691NADBy similarity
Binding sitei296 – 2961NAD; via amide nitrogenBy similarity
Binding sitei298 – 2981NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. cellular response to cAMP Source: Ensembl
  2. cellular response to tumor necrosis factor Source: Ensembl
  3. gluconeogenesis Source: Ensembl
  4. glycerol-3-phosphate catabolic process Source: InterPro
  5. glycerophosphate shuttle Source: Ensembl
  6. positive regulation of glycolytic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (EC:1.1.1.8)
Short name:
GPD-C
Short name:
GPDH-C
Gene namesi
Name:GPD1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 12

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  3. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicPRO_0000262290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei289 – 2891N6-succinyllysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RCE0.
SMRiQ5RCE0. Positions 1-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni269 – 2702Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000003114.
HOVERGENiHBG003669.
InParanoidiQ5RCE0.
KOiK00006.
OMAiPVGEFIH.
OrthoDBiEOG7ZKSBS.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RCE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKKVCIVG SGNWGSAIAK IVGGNAAQLA QFDPRVTMWV FEEDIGGKKL
60 70 80 90 100
TEIINTQHEN VKYLPGHKLP PNVVAVPDVV QAAADADILI FVVPHQFIGK
110 120 130 140 150
ICDQLKGHLK ANATGISLIK GVDEGPNGLK LISEVIGEHL GIPMSVLMGA
160 170 180 190 200
NIASEVADEK FCETTIGCKD PAQGQLLKEL MQTPNFRITV VQEVDTVEIC
210 220 230 240 250
GALKNVVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK LFRSGPVSSA
260 270 280 290 300
TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE LLNGQKLQGP
310 320 330 340
ETARELHSIL QHKGLVDKFP LFMAVYKVCY EGQPVGEFIR CLQNHPEHM
Length:349
Mass (Da):37,537
Last modified:January 23, 2007 - v3
Checksum:iB8FC0A005E326BAF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858331 mRNA. Translation: CAH90567.1.
RefSeqiNP_001125302.1. NM_001131830.1.

Genome annotation databases

EnsembliENSPPYT00000005346; ENSPPYP00000005145; ENSPPYG00000004507.
GeneIDi100172201.
KEGGipon:100172201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858331 mRNA. Translation: CAH90567.1 .
RefSeqi NP_001125302.1. NM_001131830.1.

3D structure databases

ProteinModelPortali Q5RCE0.
SMRi Q5RCE0. Positions 1-349.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000005346 ; ENSPPYP00000005145 ; ENSPPYG00000004507 .
GeneIDi 100172201.
KEGGi pon:100172201.

Organism-specific databases

CTDi 2819.

Phylogenomic databases

GeneTreei ENSGT00390000003114.
HOVERGENi HBG003669.
InParanoidi Q5RCE0.
KOi K00006.
OMAi PVGEFIH.
OrthoDBi EOG7ZKSBS.
TreeFami TF300836.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiGPDA_PONAB
AccessioniPrimary (citable) accession number: Q5RCE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3