Reviewed,
UniProtKB/Swiss-Prot Q5RC84 (HEXA_PONAB)
Last modified
November 3, 2009.
Version 30.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Beta-hexosaminidase subunit alpha EC=3.2.1.52 Alternative name(s): N-acetyl-beta-glucosaminidase subunit alpha Beta-N-acetylhexosaminidase subunit alpha Short name=Hexosaminidase subunit A | ||
| Gene names |
| ||
| Organism | Pongo abelii (Sumatran orangutan) | ||
| Taxonomic identifier | 9601 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Protein attributes
| Sequence length | 529 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues By similarity. |
| Catalytic activity | Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. |
| Subcellular location | Lysosome By similarity. |
| Sequence similarities | Belongs to the glycosyl hydrolase 20 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome |
| Domain | Signal |
| Molecular function | Glycosidase Hydrolase |
| PTM | Disulfide bond Glycoprotein Zymogen |
| Gene Ontology (GO) | |
| Cellular component | lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: EC cation bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||||
| Propeptide | 23 – 88 | 66 | By similarity | PRO_0000011997 | |||||||
| Chain | 89 – 529 | 441 | Beta-hexosaminidase subunit alpha | PRO_0000011998 | |||||||
Sites | |||||||||||
| Active site | 323 | 1 | Proton donor By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 115 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 157 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 295 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 58 ↔ 104 | By similarity | |||||||||
| Disulfide bond | 277 ↔ 328 | By similarity | |||||||||
| Disulfide bond | 505 ↔ 522 | By similarity | |||||||||
Sequences
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References
| [1] | The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex. |
Cross-references
Sequence databases | |
|---|---|
| CR858396 Transcribed RNA. Translation: CAH90623.1. | |
3D structure databases | |
| SMR | Q5RC84. Positions 23-528. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GH20. Glycoside Hydrolase Family 20. |
Phylogenomic databases | |
| HOVERGEN | Q5RC84. |
| OMA | TNLVPRL. |
Enzyme and pathway databases | |
| BRENDA | 3.2.1.52. 269192. |
Family and domain databases | |
| InterPro | IPR001540. Glyco_hydro_20. IPR015883. Glyco_hydro_20_cat-core. IPR013781. Glyco_hydro_sg_catalytic. IPR015882. HexNAc-like_b. [Graphical view] |
| Gene3D | G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit. |
| PANTHER | PTHR22600. Glyco_hydro_20. 1 hit. |
| Pfam | PF00728. Glyco_hydro_20. 1 hit. PF02838. Glyco_hydro_20b. 1 hit. [Graphical view] |
| PRINTS | PR00738. GLHYDRLASE20. |
| ProtoNet | Search... |
Entry information
| Entry name | HEXA_PONAB | ||||||||
| Accession | Primary (citable) accession number: Q5RC84 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


