Q5RC72 (KC1D_PONAB) Reviewed, UniProtKB/Swiss-Prot
Last modified February 19, 2014. Version 62. History...
Names and origin
|Protein names||Recommended name:|
Casein kinase I isoform delta
Tau-protein kinase CSNK1D
|Organism||Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]|
|Taxonomic identifier||9601 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo|
|Sequence length||415 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the cytoplasm. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate By similarity.
ATP + a protein = ADP + a phosphoprotein.
ATP + [tau protein] = ADP + [tau protein] phosphate.
Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation By similarity.
Binds to DNMT1 and MAP1A. Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with MAPT/TAU, SNAPIN, DBNDD2, AIB1/NCOA3 and ESR1. AKAP9/AKAP450 binding promotes centrosomal subcellular location. Binds to tubulins in mitotic cells upon DNA damage By similarity.
Cytoplasm By similarity. Nucleus By similarity. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome By similarity. Cytoplasm › perinuclear region By similarity. Cell membrane By similarity. Cytoplasm › cytoskeleton › spindle By similarity. Golgi apparatus By similarity. Note: Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity By similarity.
Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation By similarity.
Contains 1 protein kinase domain.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 415||415||Casein kinase I isoform delta||PRO_0000354086|
|Domain||9 – 277||269||Protein kinase|
|Nucleotide binding||15 – 23||9||ATP By similarity|
|Region||278 – 364||87||Centrosomal localization signal (CLS) By similarity|
|Region||317 – 342||26||Autoinhibitory By similarity|
|Active site||128||1||Proton acceptor By similarity|
|Binding site||38||1||ATP By similarity|
Amino acid modifications
|Modified residue||331||1||Phosphoserine By similarity|
|Modified residue||370||1||Phosphoserine By similarity|
|Modified residue||382||1||Phosphoserine By similarity|
|Modified residue||383||1||Phosphoserine By similarity|
|Modified residue||384||1||Phosphoserine By similarity|
|Modified residue||411||1||Phosphoserine By similarity|
|CR858408 mRNA. Translation: CAH90635.1.|
|RefSeq||NP_001125343.1. NM_001131871.1. |
3D structure databases
|SMR||Q5RC72. Positions 1-296. |
Protocols and materials databases
Genome annotation databases
Family and domain databases
|InterPro||IPR011009. Kinase-like_dom. |
|Pfam||PF00069. Pkinase. 1 hit. |
|SUPFAM||SSF56112. SSF56112. 1 hit. |
|PROSITE||PS00107. PROTEIN_KINASE_ATP. 1 hit. |
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
|Accession||Primary (citable) accession number: Q5RC72|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|
Index of protein domains and families