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Q5RC69 (DCTD_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxycytidylate deaminase

EC=3.5.4.12
Alternative name(s):
dCMP deaminase
Gene names
Name:DCTD
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Supplies the nucleotide substrate for thymidylate synthetase By similarity.

Catalytic activity

dCMP + H2O = dUMP + NH3.

Cofactor

Zinc By similarity.

Enzyme regulation

Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP By similarity.

Subunit structure

Homohexamer By similarity.

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termAllosteric enzyme
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiondCMP deaminase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178Deoxycytidylate deaminase
PRO_0000171693

Sites

Active site861Proton donor By similarity
Metal binding841Zinc; catalytic By similarity
Metal binding1101Zinc; catalytic By similarity
Metal binding1131Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5RC69 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 7829EA3F433280BD

FASTA17820,045
        10         20         30         40         50         60 
MSEVSCKKRD DYLEWPEYFM AVAFLSAQRS KDPNSQVGAC IVNSENKIVG IGYNGMPNGC 

        70         80         90        100        110        120 
SDDQLPWRRT AKNKLDTKYP YVCHAELNAI MNKNSTDVKG CSMYVALFPC NECAKLIIQA 

       130        140        150        160        170 
GIKEVIFMSD KYHDSDEATA ARLLFDMAGV TFRKFIPKCS KIVIDFDSIN SRPSQKLQ 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR858411 mRNA. Translation: CAH90638.1.
RefSeqXP_002815372.1. XM_002815326.2.
XP_002815373.1. XM_002815327.1.
XP_003776601.1. XM_003776553.1.

3D structure databases

ProteinModelPortalQ5RC69.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5RC69.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000017695; ENSPPYP00000017005; ENSPPYG00000015223.
GeneID100457791.
KEGGpon:100457791.

Organism-specific databases

CTD1635.

Phylogenomic databases

GeneTreeENSGT00390000000501.
HOVERGENHBG025823.
InParanoidQ5RC69.
KOK01493.
OMALMFEMAG.
OrthoDBEOG7JDQZR.
TreeFamTF105971.

Family and domain databases

InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR015517. Cyt_deaminase.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
[Graphical view]
PANTHERPTHR11086. PTHR11086. 1 hit.
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMSSF53927. SSF53927. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCTD_PONAB
AccessionPrimary (citable) accession number: Q5RC69
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families