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Q5RC69

- DCTD_PONAB

UniProt

Q5RC69 - DCTD_PONAB

Protein

Deoxycytidylate deaminase

Gene

DCTD

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Supplies the nucleotide substrate for thymidylate synthetase.By similarity

    Catalytic activityi

    dCMP + H2O = dUMP + NH3.

    Cofactori

    Zinc.By similarity

    Enzyme regulationi

    Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi84 – 841Zinc; catalyticBy similarity
    Active sitei86 – 861Proton donorBy similarity
    Metal bindingi110 – 1101Zinc; catalyticBy similarity
    Metal bindingi113 – 1131Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. dCMP deaminase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. nucleotide biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxycytidylate deaminase (EC:3.5.4.12)
    Alternative name(s):
    dCMP deaminase
    Gene namesi
    Name:DCTD
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 4

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178Deoxycytidylate deaminasePRO_0000171693Add
    BLAST

    Proteomic databases

    PRIDEiQ5RC69.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RC69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00390000000501.
    HOVERGENiHBG025823.
    InParanoidiQ5RC69.
    KOiK01493.
    OMAiKCNKIII.
    OrthoDBiEOG7JDQZR.
    TreeFamiTF105971.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR016473. dCMP_deaminase.
    IPR015517. dCMP_deaminase-rel.
    [Graphical view]
    PANTHERiPTHR11086. PTHR11086. 1 hit.
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
    SUPFAMiSSF53927. SSF53927. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5RC69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEVSCKKRD DYLEWPEYFM AVAFLSAQRS KDPNSQVGAC IVNSENKIVG    50
    IGYNGMPNGC SDDQLPWRRT AKNKLDTKYP YVCHAELNAI MNKNSTDVKG 100
    CSMYVALFPC NECAKLIIQA GIKEVIFMSD KYHDSDEATA ARLLFDMAGV 150
    TFRKFIPKCS KIVIDFDSIN SRPSQKLQ 178
    Length:178
    Mass (Da):20,045
    Last modified:December 21, 2004 - v1
    Checksum:i7829EA3F433280BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858411 mRNA. Translation: CAH90638.1.
    RefSeqiXP_002815372.1. XM_002815326.2.
    XP_002815373.1. XM_002815327.1.
    XP_003776601.1. XM_003776553.1.

    Genome annotation databases

    EnsembliENSPPYT00000017695; ENSPPYP00000017005; ENSPPYG00000015223.
    GeneIDi100457791.
    KEGGipon:100457791.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858411 mRNA. Translation: CAH90638.1 .
    RefSeqi XP_002815372.1. XM_002815326.2.
    XP_002815373.1. XM_002815327.1.
    XP_003776601.1. XM_003776553.1.

    3D structure databases

    ProteinModelPortali Q5RC69.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5RC69.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000017695 ; ENSPPYP00000017005 ; ENSPPYG00000015223 .
    GeneIDi 100457791.
    KEGGi pon:100457791.

    Organism-specific databases

    CTDi 1635.

    Phylogenomic databases

    GeneTreei ENSGT00390000000501.
    HOVERGENi HBG025823.
    InParanoidi Q5RC69.
    KOi K01493.
    OMAi KCNKIII.
    OrthoDBi EOG7JDQZR.
    TreeFami TF105971.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR016473. dCMP_deaminase.
    IPR015517. dCMP_deaminase-rel.
    [Graphical view ]
    PANTHERi PTHR11086. PTHR11086. 1 hit.
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006019. dCMP_deaminase. 1 hit.
    SUPFAMi SSF53927. SSF53927. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiDCTD_PONAB
    AccessioniPrimary (citable) accession number: Q5RC69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3