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Q5RC69

- DCTD_PONAB

UniProt

Q5RC69 - DCTD_PONAB

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Protein
Deoxycytidylate deaminase
Gene
DCTD
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Supplies the nucleotide substrate for thymidylate synthetase By similarity.

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zinc By similarity.

Enzyme regulationi

Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Zinc; catalytic By similarity
Active sitei86 – 861Proton donor By similarity
Metal bindingi110 – 1101Zinc; catalytic By similarity
Metal bindingi113 – 1131Zinc; catalytic By similarity

GO - Molecular functioni

  1. dCMP deaminase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. nucleotide biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
Name:DCTD
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 4

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Deoxycytidylate deaminase
PRO_0000171693Add
BLAST

Proteomic databases

PRIDEiQ5RC69.

Interactioni

Subunit structurei

Homohexamer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5RC69.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000000501.
HOVERGENiHBG025823.
InParanoidiQ5RC69.
KOiK01493.
OMAiKCNKIII.
OrthoDBiEOG7JDQZR.
TreeFamiTF105971.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RC69-1 [UniParc]FASTAAdd to Basket

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MSEVSCKKRD DYLEWPEYFM AVAFLSAQRS KDPNSQVGAC IVNSENKIVG    50
IGYNGMPNGC SDDQLPWRRT AKNKLDTKYP YVCHAELNAI MNKNSTDVKG 100
CSMYVALFPC NECAKLIIQA GIKEVIFMSD KYHDSDEATA ARLLFDMAGV 150
TFRKFIPKCS KIVIDFDSIN SRPSQKLQ 178
Length:178
Mass (Da):20,045
Last modified:December 21, 2004 - v1
Checksum:i7829EA3F433280BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858411 mRNA. Translation: CAH90638.1.
RefSeqiXP_002815372.1. XM_002815326.2.
XP_002815373.1. XM_002815327.1.
XP_003776601.1. XM_003776553.1.

Genome annotation databases

EnsembliENSPPYT00000017695; ENSPPYP00000017005; ENSPPYG00000015223.
GeneIDi100457791.
KEGGipon:100457791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858411 mRNA. Translation: CAH90638.1 .
RefSeqi XP_002815372.1. XM_002815326.2.
XP_002815373.1. XM_002815327.1.
XP_003776601.1. XM_003776553.1.

3D structure databases

ProteinModelPortali Q5RC69.
ModBasei Search...

Proteomic databases

PRIDEi Q5RC69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000017695 ; ENSPPYP00000017005 ; ENSPPYG00000015223 .
GeneIDi 100457791.
KEGGi pon:100457791.

Organism-specific databases

CTDi 1635.

Phylogenomic databases

GeneTreei ENSGT00390000000501.
HOVERGENi HBG025823.
InParanoidi Q5RC69.
KOi K01493.
OMAi KCNKIII.
OrthoDBi EOG7JDQZR.
TreeFami TF105971.

Family and domain databases

InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view ]
PANTHERi PTHR11086. PTHR11086. 1 hit.
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiDCTD_PONAB
AccessioniPrimary (citable) accession number: Q5RC69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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