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Protein

Signal peptidase complex catalytic subunit SEC11C

Gene

SEC11C

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPSiS26.010

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11C (EC:3.4.21.89)
Alternative name(s):
Microsomal signal peptidase 21 kDa subunit
Short name:
SPase 21 kDa subunit
SEC11 homolog C
SEC11-like protein 3
SPC21
Gene namesi
Name:SEC11C
Synonyms:SEC11L3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini49 – 192LumenalSequence analysisAdd BLAST144

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095501 – 192Signal peptidase complex catalytic subunit SEC11CAdd BLAST192

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000010320

Structurei

3D structure databases

ProteinModelPortaliQ5RC30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342 Eukaryota
COG0681 LUCA
GeneTreeiENSGT00390000015600
HOVERGENiHBG057279
InParanoidiQ5RC30
KOiK13280
OMAiWKGLIVI
OrthoDBiEOG091G0X3D
TreeFamiTF313648

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR019758 Pept_S26A_signal_pept_1_CS
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR001733 Peptidase_S26B
IPR037710 SEC11C
PANTHERiPTHR10806 PTHR10806, 1 hit
PTHR10806:SF12 PTHR10806:SF12, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00728 SIGNALPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02228 sigpep_I_arch, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5RC30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAGAVGAH LPASGLDIFG DLKKMNKRQL YYQVLNFAMI VSSALMIWKG
60 70 80 90 100
LIVLTGSESP IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE
110 120 130 140 150
GRDIPIVHRV IKVHEKDNGD IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV
160 170 180 190
VGRARGFLPY VGMVTIIMND YPKFKYALLA VMGAYVLLKR ES
Length:192
Mass (Da):21,542
Last modified:January 23, 2007 - v3
Checksum:i74FBC5F765791D9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858452 mRNA Translation: CAH90680.1
RefSeqiNP_001127320.1, NM_001133848.2
UniGeneiPab.10996

Genome annotation databases

EnsembliENSPPYT00000010728; ENSPPYP00000010320; ENSPPYG00000009189
GeneIDi100174381
KEGGipon:100174381

Similar proteinsi

Entry informationi

Entry nameiSC11C_PONAB
AccessioniPrimary (citable) accession number: Q5RC30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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