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Protein

Signal peptidase complex catalytic subunit SEC11C

Gene

SEC11C

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.022.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11C (EC:3.4.21.89)
Alternative name(s):
Microsomal signal peptidase 21 kDa subunit
Short name:
SPase 21 kDa subunit
SEC11 homolog C
SEC11-like protein 3
SPC21
Gene namesi
Name:SEC11C
Synonyms:SEC11L3
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 2827CytoplasmicSequence analysisAdd
BLAST
Transmembranei29 – 4820Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini49 – 192144LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 192191Signal peptidase complex catalytic subunit SEC11CPRO_0000109550Add
BLAST

Proteomic databases

PRIDEiQ5RC30.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000010320.

Structurei

3D structure databases

ProteinModelPortaliQ5RC30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00390000015600.
HOVERGENiHBG057279.
InParanoidiQ5RC30.
KOiK13280.
OMAiMQIRQVL.
OrthoDBiEOG7V4B0P.
TreeFamiTF313648.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RC30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAGAVGAH LPASGLDIFG DLKKMNKRQL YYQVLNFAMI VSSALMIWKG
60 70 80 90 100
LIVLTGSESP IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE
110 120 130 140 150
GRDIPIVHRV IKVHEKDNGD IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV
160 170 180 190
VGRARGFLPY VGMVTIIMND YPKFKYALLA VMGAYVLLKR ES
Length:192
Mass (Da):21,542
Last modified:January 23, 2007 - v3
Checksum:i74FBC5F765791D9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858452 mRNA. Translation: CAH90680.1.
RefSeqiNP_001127320.1. NM_001133848.2.
UniGeneiPab.10996.

Genome annotation databases

EnsembliENSPPYT00000010728; ENSPPYP00000010320; ENSPPYG00000009189.
GeneIDi100174381.
KEGGipon:100174381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858452 mRNA. Translation: CAH90680.1.
RefSeqiNP_001127320.1. NM_001133848.2.
UniGeneiPab.10996.

3D structure databases

ProteinModelPortaliQ5RC30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000010320.

Protein family/group databases

MEROPSiS26.022.

Proteomic databases

PRIDEiQ5RC30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000010728; ENSPPYP00000010320; ENSPPYG00000009189.
GeneIDi100174381.
KEGGipon:100174381.

Organism-specific databases

CTDi90701.

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
GeneTreeiENSGT00390000015600.
HOVERGENiHBG057279.
InParanoidiQ5RC30.
KOiK13280.
OMAiMQIRQVL.
OrthoDBiEOG7V4B0P.
TreeFamiTF313648.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiSC11C_PONAB
AccessioniPrimary (citable) accession number: Q5RC30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.