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Q5RC19

- ACOX1_PONAB

UniProt

Q5RC19 - ACOX1_PONAB

Protein

Peroxisomal acyl-coenzyme A oxidase 1

Gene

ACOX1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei139 – 1391FADBy similarity
    Binding sitei178 – 1781FAD; via amide nitrogenBy similarity
    Active sitei421 – 4211Proton acceptorBy similarity

    GO - Molecular functioni

    1. acyl-CoA dehydrogenase activity Source: InterPro
    2. acyl-CoA oxidase activity Source: UniProtKB
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. fatty acid beta-oxidation using acyl-CoA oxidase Source: UniProtKB-UniPathway
    2. fatty acid oxidation Source: UniProtKB
    3. generation of precursor metabolites and energy Source: UniProtKB
    4. lipid metabolic process Source: UniProtKB
    5. prostaglandin metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00661.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 1 (EC:1.3.3.6)
    Short name:
    AOX
    Alternative name(s):
    Palmitoyl-CoA oxidase
    Gene namesi
    Name:ACOX1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 660660Peroxisomal acyl-coenzyme A oxidase 1PRO_0000204680Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261PhosphoserineBy similarity
    Modified residuei89 – 891N6-succinyllysineBy similarity
    Modified residuei90 – 901N6-succinyllysineBy similarity
    Modified residuei216 – 2161N6-acetyllysineBy similarity
    Modified residuei241 – 2411N6-succinyllysineBy similarity
    Modified residuei255 – 2551N6-acetyllysineBy similarity
    Modified residuei267 – 2671N6-acetyllysineBy similarity
    Modified residuei272 – 2721N6-acetyllysineBy similarity
    Modified residuei349 – 3491N6-succinyllysineBy similarity
    Modified residuei437 – 4371N6-acetyllysine; alternateBy similarity
    Modified residuei437 – 4371N6-succinyllysine; alternateBy similarity
    Modified residuei446 – 4461N6-acetyllysine; alternateBy similarity
    Modified residuei446 – 4461N6-succinyllysine; alternateBy similarity
    Modified residuei500 – 5001N6-acetyllysineBy similarity
    Modified residuei512 – 5121N6-acetyllysine; alternateBy similarity
    Modified residuei512 – 5121N6-succinyllysine; alternateBy similarity
    Modified residuei542 – 5421N6-succinyllysineBy similarity
    Modified residuei637 – 6371N6-acetyllysine; alternateBy similarity
    Modified residuei637 – 6371N6-succinyllysine; alternateBy similarity
    Modified residuei643 – 6431N6-succinyllysineBy similarity
    Modified residuei651 – 6511N6-acetyllysineBy similarity
    Modified residuei654 – 6541N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ5RC19.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RC19.
    SMRiQ5RC19. Positions 1-654.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi658 – 6603Microbody targeting signalBy similarity

    Sequence similaritiesi

    Belongs to the acyl-CoA oxidase family.Curated

    Phylogenomic databases

    HOVERGENiHBG050451.
    KOiK00232.

    Family and domain databases

    Gene3Di1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProiIPR029320. Acyl-CoA_ox_N.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR012258. Acyl-CoA_oxidase.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    PfamiPF01756. ACOX. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF14749. Acyl-CoA_ox_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
    SUPFAMiSSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5RC19-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNPDLRRERD SASFNPELLT HILDGSPEKT RRRREIENMI LNDPDFQHED    50
    LNFLTRSQRY EVAVRKSAIM VKKMREFGIA DPDEIMWFKK LHLVNFVEPV 100
    GLNYSMFIPT LLNQGTTAQK EKWLLSSKGL QIIGTYAQTE MGHGTHLRGL 150
    ETTATYDPET QEFILNSPTV TSIKWWPGGL GKTSNHAIVL AQLITKGKGY 200
    GLHAFIVPIR EIGTHKPLPG ITVGDIGPKF GYDEIDNGYL KMDNYRIPRE 250
    NMLMKYAQVK PDGTYVKPLS NKLTYGTMVF VRSFLVGEAA RALSKACTIA 300
    IRYSAVRHQS EIKPGEPEPQ ILDFQTQQYK LFPLLATAYA FQFVGAYMKE 350
    TYHRINEGIG QGDLSELPEL HALTAGLKAF TSWTANTGIE ACRMACGGHG 400
    YSHCSGLPNI YVNFTPSCTF EGENTVMMLQ TARFLMKSYD QVHSGKLVCG 450
    MVSYLNDLPS QRIQPQQVAV WPTMVDIHSP ESLTEAYKLR AARLVEIAAK 500
    NLQKEVIHRK SKEVAWNLTS VDLVRASEAH CHYVVVKLFS EKLLKIQDKA 550
    IQAVLRNLCL LYSLYGISQN AGDFLQGSIM TEPQITQVNQ RVKELLTLIR 600
    SDAVALVDAF DFQDVTLGSV LGRYDGNVYE NLFEWAKNSP LNKAEVHESY 650
    KHLKSLQSKL 660
    Length:660
    Mass (Da):74,454
    Last modified:March 29, 2005 - v2
    Checksum:i99A0A2EF19331211
    GO
    Isoform 2 (identifier: Q5RC19-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         90-131: KLHLVNFVEP...KWLLSSKGLQ → NFVHRGRPEP...RFFMPAWNLE

    Show »
    Length:660
    Mass (Da):74,698
    Checksum:i38AF43D05A3BCCD8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti284 – 2841F → L in CAH90691. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei90 – 13142KLHLV…SKGLQ → NFVHRGRPEPLDLHLGMFLP TLLHQATAEQQERFFMPAWN LE in isoform 2. 1 PublicationVSP_013217Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858463 mRNA. Translation: CAH90691.1.
    CR859802 mRNA. Translation: CAH91960.1.
    RefSeqiNP_001125380.1. NM_001131908.1.
    NP_001128843.1. NM_001135371.1. [Q5RC19-1]
    UniGeneiPab.19225.

    Genome annotation databases

    GeneIDi100172283.
    100189759.
    KEGGipon:100172283.
    pon:100189759.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858463 mRNA. Translation: CAH90691.1 .
    CR859802 mRNA. Translation: CAH91960.1 .
    RefSeqi NP_001125380.1. NM_001131908.1.
    NP_001128843.1. NM_001135371.1. [Q5RC19-1 ]
    UniGenei Pab.19225.

    3D structure databases

    ProteinModelPortali Q5RC19.
    SMRi Q5RC19. Positions 1-654.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5RC19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100172283.
    100189759.
    KEGGi pon:100172283.
    pon:100189759.

    Organism-specific databases

    CTDi 51.

    Phylogenomic databases

    HOVERGENi HBG050451.
    KOi K00232.

    Enzyme and pathway databases

    UniPathwayi UPA00661 .

    Family and domain databases

    Gene3Di 1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProi IPR029320. Acyl-CoA_ox_N.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR012258. Acyl-CoA_oxidase.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    Pfami PF01756. ACOX. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF14749. Acyl-CoA_ox_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000168. Acyl-CoA_oxidase. 1 hit.
    SUPFAMi SSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Heart and Kidney.

    Entry informationi

    Entry nameiACOX1_PONAB
    AccessioniPrimary (citable) accession number: Q5RC19
    Secondary accession number(s): Q5R8F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3