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Q5RC19 (ACOX1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal acyl-coenzyme A oxidase 1

Short name=AOX
EC=1.3.3.6
Alternative name(s):
Palmitoyl-CoA oxidase
Gene names
Name:ACOX1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length660 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs By similarity.

Catalytic activity

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactor

FAD By similarity.

Pathway

Lipid metabolism; peroxisomal fatty acid beta-oxidation.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the acyl-CoA oxidase family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5RC19-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5RC19-2)

The sequence of this isoform differs from the canonical sequence as follows:
     90-131: KLHLVNFVEP...KWLLSSKGLQ → NFVHRGRPEP...RFFMPAWNLE

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 660660Peroxisomal acyl-coenzyme A oxidase 1
PRO_0000204680

Regions

Motif658 – 6603Microbody targeting signal By similarity

Sites

Active site4211Proton acceptor By similarity
Binding site1391FAD By similarity
Binding site1781FAD; via amide nitrogen By similarity

Amino acid modifications

Modified residue261Phosphoserine By similarity
Modified residue891N6-succinyllysine By similarity
Modified residue901N6-succinyllysine By similarity
Modified residue2161N6-acetyllysine By similarity
Modified residue2411N6-succinyllysine By similarity
Modified residue2551N6-acetyllysine By similarity
Modified residue2671N6-acetyllysine By similarity
Modified residue2721N6-acetyllysine By similarity
Modified residue3491N6-succinyllysine By similarity
Modified residue4371N6-acetyllysine; alternate By similarity
Modified residue4371N6-succinyllysine; alternate By similarity
Modified residue4461N6-acetyllysine; alternate By similarity
Modified residue4461N6-succinyllysine; alternate By similarity
Modified residue5001N6-acetyllysine By similarity
Modified residue5121N6-acetyllysine; alternate By similarity
Modified residue5121N6-succinyllysine; alternate By similarity
Modified residue5421N6-succinyllysine By similarity
Modified residue6371N6-acetyllysine; alternate By similarity
Modified residue6371N6-succinyllysine; alternate By similarity
Modified residue6431N6-succinyllysine By similarity
Modified residue6511N6-acetyllysine By similarity
Modified residue6541N6-succinyllysine By similarity

Natural variations

Alternative sequence90 – 13142KLHLV…SKGLQ → NFVHRGRPEPLDLHLGMFLP TLLHQATAEQQERFFMPAWN LE in isoform 2.
VSP_013217

Experimental info

Sequence conflict2841F → L in CAH90691. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 29, 2005. Version 2.
Checksum: 99A0A2EF19331211

FASTA66074,454
        10         20         30         40         50         60 
MNPDLRRERD SASFNPELLT HILDGSPEKT RRRREIENMI LNDPDFQHED LNFLTRSQRY 

        70         80         90        100        110        120 
EVAVRKSAIM VKKMREFGIA DPDEIMWFKK LHLVNFVEPV GLNYSMFIPT LLNQGTTAQK 

       130        140        150        160        170        180 
EKWLLSSKGL QIIGTYAQTE MGHGTHLRGL ETTATYDPET QEFILNSPTV TSIKWWPGGL 

       190        200        210        220        230        240 
GKTSNHAIVL AQLITKGKGY GLHAFIVPIR EIGTHKPLPG ITVGDIGPKF GYDEIDNGYL 

       250        260        270        280        290        300 
KMDNYRIPRE NMLMKYAQVK PDGTYVKPLS NKLTYGTMVF VRSFLVGEAA RALSKACTIA 

       310        320        330        340        350        360 
IRYSAVRHQS EIKPGEPEPQ ILDFQTQQYK LFPLLATAYA FQFVGAYMKE TYHRINEGIG 

       370        380        390        400        410        420 
QGDLSELPEL HALTAGLKAF TSWTANTGIE ACRMACGGHG YSHCSGLPNI YVNFTPSCTF 

       430        440        450        460        470        480 
EGENTVMMLQ TARFLMKSYD QVHSGKLVCG MVSYLNDLPS QRIQPQQVAV WPTMVDIHSP 

       490        500        510        520        530        540 
ESLTEAYKLR AARLVEIAAK NLQKEVIHRK SKEVAWNLTS VDLVRASEAH CHYVVVKLFS 

       550        560        570        580        590        600 
EKLLKIQDKA IQAVLRNLCL LYSLYGISQN AGDFLQGSIM TEPQITQVNQ RVKELLTLIR 

       610        620        630        640        650        660 
SDAVALVDAF DFQDVTLGSV LGRYDGNVYE NLFEWAKNSP LNKAEVHESY KHLKSLQSKL 

« Hide

Isoform 2 [UniParc].

Checksum: 38AF43D05A3BCCD8
Show »

FASTA66074,698

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Heart and Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR858463 mRNA. Translation: CAH90691.1.
CR859802 mRNA. Translation: CAH91960.1.
RefSeqNP_001125380.1. NM_001131908.1.
NP_001128843.1. NM_001135371.1.
UniGenePab.19225.

3D structure databases

ProteinModelPortalQ5RC19.
SMRQ5RC19. Positions 1-654.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5RC19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100172283.
100189759.
KEGGpon:100172283.
pon:100189759.

Organism-specific databases

CTD51.

Phylogenomic databases

HOVERGENHBG050451.
KOK00232.

Enzyme and pathway databases

UniPathwayUPA00661.

Family and domain databases

Gene3D1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PANTHERPTHR10909:SF11. PTHR10909:SF11. 1 hit.
PfamPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACOX1_PONAB
AccessionPrimary (citable) accession number: Q5RC19
Secondary accession number(s): Q5R8F0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: April 16, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways