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Q5RC19

- ACOX1_PONAB

UniProt

Q5RC19 - ACOX1_PONAB

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Protein

Peroxisomal acyl-coenzyme A oxidase 1

Gene

ACOX1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity).By similarity

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

FAD.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391FADBy similarity
Binding sitei178 – 1781FAD; via amide nitrogenBy similarity
Active sitei421 – 4211Proton acceptorBy similarity

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. acyl-CoA oxidase activity Source: UniProtKB
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid beta-oxidation using acyl-CoA oxidase Source: UniProtKB-UniPathway
  2. fatty acid oxidation Source: UniProtKB
  3. generation of precursor metabolites and energy Source: UniProtKB
  4. lipid metabolic process Source: UniProtKB
  5. prostaglandin metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 1 (EC:1.3.3.6)
Short name:
AOX
Alternative name(s):
Palmitoyl-CoA oxidase
Gene namesi
Name:ACOX1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Peroxisomal acyl-coenzyme A oxidase 1PRO_0000204680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261PhosphoserineBy similarity
Modified residuei89 – 891N6-succinyllysineBy similarity
Modified residuei90 – 901N6-succinyllysineBy similarity
Modified residuei216 – 2161N6-acetyllysineBy similarity
Modified residuei241 – 2411N6-succinyllysineBy similarity
Modified residuei255 – 2551N6-acetyllysineBy similarity
Modified residuei267 – 2671N6-acetyllysineBy similarity
Modified residuei272 – 2721N6-acetyllysineBy similarity
Modified residuei349 – 3491N6-succinyllysineBy similarity
Modified residuei437 – 4371N6-acetyllysine; alternateBy similarity
Modified residuei437 – 4371N6-succinyllysine; alternateBy similarity
Modified residuei446 – 4461N6-acetyllysine; alternateBy similarity
Modified residuei446 – 4461N6-succinyllysine; alternateBy similarity
Modified residuei500 – 5001N6-acetyllysineBy similarity
Modified residuei512 – 5121N6-acetyllysine; alternateBy similarity
Modified residuei512 – 5121N6-succinyllysine; alternateBy similarity
Modified residuei542 – 5421N6-succinyllysineBy similarity
Modified residuei637 – 6371N6-acetyllysine; alternateBy similarity
Modified residuei637 – 6371N6-succinyllysine; alternateBy similarity
Modified residuei643 – 6431N6-succinyllysineBy similarity
Modified residuei651 – 6511N6-acetyllysineBy similarity
Modified residuei654 – 6541N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ5RC19.

Structurei

3D structure databases

ProteinModelPortaliQ5RC19.
SMRiQ5RC19. Positions 1-654.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi658 – 6603Microbody targeting signalBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

HOVERGENiHBG050451.
InParanoidiQ5RC19.
KOiK00232.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5RC19-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPDLRRERD SASFNPELLT HILDGSPEKT RRRREIENMI LNDPDFQHED
60 70 80 90 100
LNFLTRSQRY EVAVRKSAIM VKKMREFGIA DPDEIMWFKK LHLVNFVEPV
110 120 130 140 150
GLNYSMFIPT LLNQGTTAQK EKWLLSSKGL QIIGTYAQTE MGHGTHLRGL
160 170 180 190 200
ETTATYDPET QEFILNSPTV TSIKWWPGGL GKTSNHAIVL AQLITKGKGY
210 220 230 240 250
GLHAFIVPIR EIGTHKPLPG ITVGDIGPKF GYDEIDNGYL KMDNYRIPRE
260 270 280 290 300
NMLMKYAQVK PDGTYVKPLS NKLTYGTMVF VRSFLVGEAA RALSKACTIA
310 320 330 340 350
IRYSAVRHQS EIKPGEPEPQ ILDFQTQQYK LFPLLATAYA FQFVGAYMKE
360 370 380 390 400
TYHRINEGIG QGDLSELPEL HALTAGLKAF TSWTANTGIE ACRMACGGHG
410 420 430 440 450
YSHCSGLPNI YVNFTPSCTF EGENTVMMLQ TARFLMKSYD QVHSGKLVCG
460 470 480 490 500
MVSYLNDLPS QRIQPQQVAV WPTMVDIHSP ESLTEAYKLR AARLVEIAAK
510 520 530 540 550
NLQKEVIHRK SKEVAWNLTS VDLVRASEAH CHYVVVKLFS EKLLKIQDKA
560 570 580 590 600
IQAVLRNLCL LYSLYGISQN AGDFLQGSIM TEPQITQVNQ RVKELLTLIR
610 620 630 640 650
SDAVALVDAF DFQDVTLGSV LGRYDGNVYE NLFEWAKNSP LNKAEVHESY
660
KHLKSLQSKL
Length:660
Mass (Da):74,454
Last modified:March 29, 2005 - v2
Checksum:i99A0A2EF19331211
GO
Isoform 2 (identifier: Q5RC19-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-131: KLHLVNFVEP...KWLLSSKGLQ → NFVHRGRPEP...RFFMPAWNLE

Show »
Length:660
Mass (Da):74,698
Checksum:i38AF43D05A3BCCD8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti284 – 2841F → L in CAH90691. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei90 – 13142KLHLV…SKGLQ → NFVHRGRPEPLDLHLGMFLP TLLHQATAEQQERFFMPAWN LE in isoform 2. 1 PublicationVSP_013217Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858463 mRNA. Translation: CAH90691.1.
CR859802 mRNA. Translation: CAH91960.1.
RefSeqiNP_001125380.1. NM_001131908.1.
NP_001128843.1. NM_001135371.1. [Q5RC19-1]
UniGeneiPab.19225.

Genome annotation databases

GeneIDi100172283.
100189759.
KEGGipon:100172283.
pon:100189759.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858463 mRNA. Translation: CAH90691.1 .
CR859802 mRNA. Translation: CAH91960.1 .
RefSeqi NP_001125380.1. NM_001131908.1.
NP_001128843.1. NM_001135371.1. [Q5RC19-1 ]
UniGenei Pab.19225.

3D structure databases

ProteinModelPortali Q5RC19.
SMRi Q5RC19. Positions 1-654.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5RC19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100172283.
100189759.
KEGGi pon:100172283.
pon:100189759.

Organism-specific databases

CTDi 51.

Phylogenomic databases

HOVERGENi HBG050451.
InParanoidi Q5RC19.
KOi K00232.

Enzyme and pathway databases

UniPathwayi UPA00661 .

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMi SSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Heart and Kidney.

Entry informationi

Entry nameiACOX1_PONAB
AccessioniPrimary (citable) accession number: Q5RC19
Secondary accession number(s): Q5R8F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3