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Protein

Epidermal growth factor receptor kinase substrate 8-like protein 2

Gene

EPS8L2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor receptor kinase substrate 8-like protein 2
Short name:
EPS8-like protein 2
Alternative name(s):
Epidermal growth factor receptor pathway substrate 8-related protein 2
Short name:
EPS8-related protein 2
Gene namesi
Name:EPS8L2
Synonyms:EPS8R2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595 Componenti: Unplaced

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Epidermal growth factor receptor kinase substrate 8-like protein 2PRO_0000239086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei240 – 2401PhosphoserineBy similarity
Modified residuei304 – 3041PhosphothreonineBy similarity
Modified residuei450 – 4501PhosphoserineBy similarity
Modified residuei470 – 4701PhosphothreonineBy similarity
Modified residuei571 – 5711PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5RC07.

Interactioni

Subunit structurei

Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin (By similarity).By similarity

Structurei

3D structure databases

SMRiQ5RC07. Positions 495-556, 613-698.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 202157PIDAdd
BLAST
Domaini493 – 55260SH3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the EPS8 family.Curated
Contains 1 PID domain.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

HOVERGENiHBG003090.
InParanoidiQ5RC07.
KOiK17277.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RC07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSGTMSCC PGATNGSLGR SDGVAKMSPK DLFEQRKKYS NSNVIMHETS
60 70 80 90 100
QYHVQHLATF IMDKSEAITS VDDAIRKLVQ LSSKEKIWTQ EMLLQVNDQS
110 120 130 140 150
LRLLDIESQE ELENFPLPTV QRSQTVLNQL RYPSVLLLVC QDSEQSKPDV
160 170 180 190 200
HFFHCDEVEA ELVHEDIESA LADCRLGKKM RPQTLKGHQE KIRQRQSILP
210 220 230 240 250
PPQGPAPIPF QHRGGDSPQA KNRVGPQVPL SEPGFRRRES QEEEPRALLA
260 270 280 290 300
QKIEKETQIL NCALDDIEWF VARLQKAAEA FKQLNQRKKG KKKGKKAPAE
310 320 330 340 350
GVLTLRARPP SEGEFIDCFQ KTKLAINLLA KLQKHIQNPS AAELVHFLFG
360 370 380 390 400
PLDLIVNTCG GPDIARSVSC PLLSRDAVDF LRGHLVPKEM SLWESLGESW
410 420 430 440 450
MRPRSEWPWE PQVPLYVPKF HSGWEPPMDV LQEAPWEVEG LASAPIEEVS
460 470 480 490 500
PVSRQSIRNS QKHSPTSEPT PPGDALPPVS SPHTHRGYQP TPAMAKYVKI
510 520 530 540 550
LYDFTARNAN ELSVLKDEVL EVLEDGRQWW KLRSRSGQAG YVPCNILGEA
560 570 580 590 600
RPEDAGAPFE QAGQKYWGPA SPTHKLPPSF PGNKDELMQH MDEVNDELIR
610 620 630 640 650
KISNIRAQPQ RHFRVERSQP VSQPLTYESG PDEVRAWLEA KAFSPRIVEN
660 670 680 690 700
LGILTGPQLF SLNKEELKKV CGEEGVRVYS QLTVQKAFLE KQQSGSELEE
710
LMNKFHSMNQ RRGEDS
Length:716
Mass (Da):80,812
Last modified:December 21, 2004 - v1
Checksum:i2A2A4747ED160CE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858475 mRNA. Translation: CAH90703.1.
RefSeqiNP_001125388.1. NM_001131916.1.
UniGeneiPab.7104.

Genome annotation databases

GeneIDi100172293.
KEGGipon:100172293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858475 mRNA. Translation: CAH90703.1.
RefSeqiNP_001125388.1. NM_001131916.1.
UniGeneiPab.7104.

3D structure databases

SMRiQ5RC07. Positions 495-556, 613-698.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5RC07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100172293.
KEGGipon:100172293.

Organism-specific databases

CTDi64787.

Phylogenomic databases

HOVERGENiHBG003090.
InParanoidiQ5RC07.
KOiK17277.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiES8L2_PONAB
AccessioniPrimary (citable) accession number: Q5RC07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 21, 2004
Last modified: April 1, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.