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Q5RC07

- ES8L2_PONAB

UniProt

Q5RC07 - ES8L2_PONAB

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Protein

Epidermal growth factor receptor kinase substrate 8-like protein 2

Gene
EPS8L2, EPS8R2
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor receptor kinase substrate 8-like protein 2
Short name:
EPS8-like protein 2
Alternative name(s):
Epidermal growth factor receptor pathway substrate 8-related protein 2
Short name:
EPS8-related protein 2
Gene namesi
Name:EPS8L2
Synonyms:EPS8R2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Epidermal growth factor receptor kinase substrate 8-like protein 2PRO_0000239086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei304 – 3041Phosphothreonine By similarity
Modified residuei450 – 4501Phosphoserine By similarity
Modified residuei470 – 4701Phosphothreonine By similarity
Modified residuei571 – 5711Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5RC07.

Interactioni

Subunit structurei

Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5RC07.
SMRiQ5RC07. Positions 495-556, 613-698.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 202157PIDAdd
BLAST
Domaini493 – 55260SH3Add
BLAST

Sequence similaritiesi

Belongs to the EPS8 family.
Contains 1 PID domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

HOVERGENiHBG003090.
InParanoidiQ5RC07.
KOiK17277.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5RC07-1 [UniParc]FASTAAdd to Basket

« Hide

MSQSGTMSCC PGATNGSLGR SDGVAKMSPK DLFEQRKKYS NSNVIMHETS    50
QYHVQHLATF IMDKSEAITS VDDAIRKLVQ LSSKEKIWTQ EMLLQVNDQS 100
LRLLDIESQE ELENFPLPTV QRSQTVLNQL RYPSVLLLVC QDSEQSKPDV 150
HFFHCDEVEA ELVHEDIESA LADCRLGKKM RPQTLKGHQE KIRQRQSILP 200
PPQGPAPIPF QHRGGDSPQA KNRVGPQVPL SEPGFRRRES QEEEPRALLA 250
QKIEKETQIL NCALDDIEWF VARLQKAAEA FKQLNQRKKG KKKGKKAPAE 300
GVLTLRARPP SEGEFIDCFQ KTKLAINLLA KLQKHIQNPS AAELVHFLFG 350
PLDLIVNTCG GPDIARSVSC PLLSRDAVDF LRGHLVPKEM SLWESLGESW 400
MRPRSEWPWE PQVPLYVPKF HSGWEPPMDV LQEAPWEVEG LASAPIEEVS 450
PVSRQSIRNS QKHSPTSEPT PPGDALPPVS SPHTHRGYQP TPAMAKYVKI 500
LYDFTARNAN ELSVLKDEVL EVLEDGRQWW KLRSRSGQAG YVPCNILGEA 550
RPEDAGAPFE QAGQKYWGPA SPTHKLPPSF PGNKDELMQH MDEVNDELIR 600
KISNIRAQPQ RHFRVERSQP VSQPLTYESG PDEVRAWLEA KAFSPRIVEN 650
LGILTGPQLF SLNKEELKKV CGEEGVRVYS QLTVQKAFLE KQQSGSELEE 700
LMNKFHSMNQ RRGEDS 716
Length:716
Mass (Da):80,812
Last modified:December 21, 2004 - v1
Checksum:i2A2A4747ED160CE5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858475 mRNA. Translation: CAH90703.1.
RefSeqiNP_001125388.1. NM_001131916.1.
UniGeneiPab.7104.

Genome annotation databases

GeneIDi100172293.
KEGGipon:100172293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858475 mRNA. Translation: CAH90703.1 .
RefSeqi NP_001125388.1. NM_001131916.1.
UniGenei Pab.7104.

3D structure databases

ProteinModelPortali Q5RC07.
SMRi Q5RC07. Positions 495-556, 613-698.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5RC07.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100172293.
KEGGi pon:100172293.

Organism-specific databases

CTDi 64787.

Phylogenomic databases

HOVERGENi HBG003090.
InParanoidi Q5RC07.
KOi K17277.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiES8L2_PONAB
AccessioniPrimary (citable) accession number: Q5RC07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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