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Q5RC07

- ES8L2_PONAB

UniProt

Q5RC07 - ES8L2_PONAB

Protein

Epidermal growth factor receptor kinase substrate 8-like protein 2

Gene

EPS8L2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epidermal growth factor receptor kinase substrate 8-like protein 2
    Short name:
    EPS8-like protein 2
    Alternative name(s):
    Epidermal growth factor receptor pathway substrate 8-related protein 2
    Short name:
    EPS8-related protein 2
    Gene namesi
    Name:EPS8L2
    Synonyms:EPS8R2
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 716716Epidermal growth factor receptor kinase substrate 8-like protein 2PRO_0000239086Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei304 – 3041PhosphothreonineBy similarity
    Modified residuei450 – 4501PhosphoserineBy similarity
    Modified residuei470 – 4701PhosphothreonineBy similarity
    Modified residuei571 – 5711PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ5RC07.

    Interactioni

    Subunit structurei

    Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RC07.
    SMRiQ5RC07. Positions 495-556, 613-698.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 202157PIDAdd
    BLAST
    Domaini493 – 55260SH3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the EPS8 family.Curated
    Contains 1 PID domain.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    HOVERGENiHBG003090.
    InParanoidiQ5RC07.
    KOiK17277.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR013625. PTB.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF08416. PTB. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5RC07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQSGTMSCC PGATNGSLGR SDGVAKMSPK DLFEQRKKYS NSNVIMHETS    50
    QYHVQHLATF IMDKSEAITS VDDAIRKLVQ LSSKEKIWTQ EMLLQVNDQS 100
    LRLLDIESQE ELENFPLPTV QRSQTVLNQL RYPSVLLLVC QDSEQSKPDV 150
    HFFHCDEVEA ELVHEDIESA LADCRLGKKM RPQTLKGHQE KIRQRQSILP 200
    PPQGPAPIPF QHRGGDSPQA KNRVGPQVPL SEPGFRRRES QEEEPRALLA 250
    QKIEKETQIL NCALDDIEWF VARLQKAAEA FKQLNQRKKG KKKGKKAPAE 300
    GVLTLRARPP SEGEFIDCFQ KTKLAINLLA KLQKHIQNPS AAELVHFLFG 350
    PLDLIVNTCG GPDIARSVSC PLLSRDAVDF LRGHLVPKEM SLWESLGESW 400
    MRPRSEWPWE PQVPLYVPKF HSGWEPPMDV LQEAPWEVEG LASAPIEEVS 450
    PVSRQSIRNS QKHSPTSEPT PPGDALPPVS SPHTHRGYQP TPAMAKYVKI 500
    LYDFTARNAN ELSVLKDEVL EVLEDGRQWW KLRSRSGQAG YVPCNILGEA 550
    RPEDAGAPFE QAGQKYWGPA SPTHKLPPSF PGNKDELMQH MDEVNDELIR 600
    KISNIRAQPQ RHFRVERSQP VSQPLTYESG PDEVRAWLEA KAFSPRIVEN 650
    LGILTGPQLF SLNKEELKKV CGEEGVRVYS QLTVQKAFLE KQQSGSELEE 700
    LMNKFHSMNQ RRGEDS 716
    Length:716
    Mass (Da):80,812
    Last modified:December 21, 2004 - v1
    Checksum:i2A2A4747ED160CE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858475 mRNA. Translation: CAH90703.1.
    RefSeqiNP_001125388.1. NM_001131916.1.
    UniGeneiPab.7104.

    Genome annotation databases

    GeneIDi100172293.
    KEGGipon:100172293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858475 mRNA. Translation: CAH90703.1 .
    RefSeqi NP_001125388.1. NM_001131916.1.
    UniGenei Pab.7104.

    3D structure databases

    ProteinModelPortali Q5RC07.
    SMRi Q5RC07. Positions 495-556, 613-698.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5RC07.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100172293.
    KEGGi pon:100172293.

    Organism-specific databases

    CTDi 64787.

    Phylogenomic databases

    HOVERGENi HBG003090.
    InParanoidi Q5RC07.
    KOi K17277.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR013625. PTB.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF08416. PTB. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiES8L2_PONAB
    AccessioniPrimary (citable) accession number: Q5RC07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3