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Q5RC07 (ES8L2_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Epidermal growth factor receptor kinase substrate 8-like protein 2
Short name=EPS8-like protein 2
Alternative name(s):
Epidermal growth factor receptor pathway substrate 8-related protein 2
Short name=EPS8-related protein 2
Gene names
Name:EPS8L2
Synonyms:EPS8R2
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length716 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton By similarity.

Subunit structure

Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the EPS8 family.

Contains 1 PID domain.

Contains 1 SH3 domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainSH3 domain
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 716716Epidermal growth factor receptor kinase substrate 8-like protein 2
PRO_0000239086

Regions

Domain46 – 202157PID
Domain493 – 55260SH3

Amino acid modifications

Modified residue2401Phosphoserine By similarity
Modified residue4501Phosphoserine By similarity
Modified residue4701Phosphothreonine By similarity
Modified residue4811Phosphoserine By similarity
Modified residue5711Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5RC07 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 2A2A4747ED160CE5

FASTA71680,812
        10         20         30         40         50         60 
MSQSGTMSCC PGATNGSLGR SDGVAKMSPK DLFEQRKKYS NSNVIMHETS QYHVQHLATF 

        70         80         90        100        110        120 
IMDKSEAITS VDDAIRKLVQ LSSKEKIWTQ EMLLQVNDQS LRLLDIESQE ELENFPLPTV 

       130        140        150        160        170        180 
QRSQTVLNQL RYPSVLLLVC QDSEQSKPDV HFFHCDEVEA ELVHEDIESA LADCRLGKKM 

       190        200        210        220        230        240 
RPQTLKGHQE KIRQRQSILP PPQGPAPIPF QHRGGDSPQA KNRVGPQVPL SEPGFRRRES 

       250        260        270        280        290        300 
QEEEPRALLA QKIEKETQIL NCALDDIEWF VARLQKAAEA FKQLNQRKKG KKKGKKAPAE 

       310        320        330        340        350        360 
GVLTLRARPP SEGEFIDCFQ KTKLAINLLA KLQKHIQNPS AAELVHFLFG PLDLIVNTCG 

       370        380        390        400        410        420 
GPDIARSVSC PLLSRDAVDF LRGHLVPKEM SLWESLGESW MRPRSEWPWE PQVPLYVPKF 

       430        440        450        460        470        480 
HSGWEPPMDV LQEAPWEVEG LASAPIEEVS PVSRQSIRNS QKHSPTSEPT PPGDALPPVS 

       490        500        510        520        530        540 
SPHTHRGYQP TPAMAKYVKI LYDFTARNAN ELSVLKDEVL EVLEDGRQWW KLRSRSGQAG 

       550        560        570        580        590        600 
YVPCNILGEA RPEDAGAPFE QAGQKYWGPA SPTHKLPPSF PGNKDELMQH MDEVNDELIR 

       610        620        630        640        650        660 
KISNIRAQPQ RHFRVERSQP VSQPLTYESG PDEVRAWLEA KAFSPRIVEN LGILTGPQLF 

       670        680        690        700        710 
SLNKEELKKV CGEEGVRVYS QLTVQKAFLE KQQSGSELEE LMNKFHSMNQ RRGEDS

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR858475 mRNA. Translation: CAH90703.1.
RefSeqNP_001125388.1. NM_001131916.1.
UniGenePab.7104.

3D structure databases

ProteinModelPortalQ5RC07.
SMRQ5RC07. Positions 495-556, 613-698.
ModBaseSearch...

Proteomic databases

PRIDEQ5RC07.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100172293.
KEGGpon:100172293.

Organism-specific databases

CTD64787.

Phylogenomic databases

HOVERGENHBG003090.
InParanoidQ5RC07.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR011993. PH_like_dom.
IPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]
PfamPF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SH3. 1 hit.
PROSITEPS01179. PID. False negative.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameES8L2_PONAB
AccessionPrimary (citable) accession number: Q5RC07
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 21, 2004
Last modified: March 6, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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