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Q5RBS3

- SERPH_PONAB

UniProt

Q5RBS3 - SERPH_PONAB

Protein

Serpin H1

Gene

SERPINH1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei376 – 3772Reactive bond homologBy similarity

    Keywords - Molecular functioni

    Chaperone

    Protein family/group databases

    MEROPSiI04.036.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin H1
    Alternative name(s):
    Collagen-binding protein
    Short name:
    Colligin
    Gene namesi
    Name:SERPINH1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    2. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 417399Serpin H1PRO_0000253605Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei94 – 941N6-succinyllysineBy similarity
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Modified residuei206 – 2061N6-acetyllysineBy similarity
    Modified residuei295 – 2951N6-succinyllysineBy similarity
    Modified residuei318 – 3181N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    PRIDEiQ5RBS3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RBS3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi414 – 4174Prevents secretion from ERPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi25 – 295Poly-Ala

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG104930.
    KOiK09501.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5RBS3-1 [UniParc]FASTAAdd to Basket

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    MRSLLLLSAF CLLEAALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL    50
    AFSLYQAMAK DQAVENILVS PVVVASSLGL VSLGGKATTA SQAKAVLSAE 100
    QLRDEEVHAG LGELLRSLSN STARNVTWKL GSRLYGPSSV SFADDFVRTA 150
    SSTTTASTPR STSATSAALQ SINEWAAQTT DGKLPEVTKD VERTDGALLV 200
    NAMFFKPHWD EKFHHKMVDN RGFMVTRSYT VGVMMMHRTG LYNYYDDEKE 250
    KLQIVEMPLA HKLSSLIILM PHHVEPLERL EKLLTKEQLK IWMGKMQKKA 300
    VAISLPKGVV EVTHDLQKHL AGLGLTEAID KNKADLSRMS GKKDLYLASV 350
    FHATAFELDT DGNPFDQDIY GREELRSPKL FYADHPFIFL VRDTQSGSLL 400
    FIGRLVRPKG DKMRDEL 417
    Length:417
    Mass (Da):45,762
    Last modified:December 21, 2004 - v1
    Checksum:iBF7BA00DAC59FEC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858522 mRNA. Translation: CAH90749.1.
    CR858561 mRNA. Translation: CAH90787.1.
    RefSeqiNP_001125445.1. NM_001131973.1.
    UniGeneiPab.17407.

    Genome annotation databases

    GeneIDi100172353.
    KEGGipon:100172353.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858522 mRNA. Translation: CAH90749.1 .
    CR858561 mRNA. Translation: CAH90787.1 .
    RefSeqi NP_001125445.1. NM_001131973.1.
    UniGenei Pab.17407.

    3D structure databases

    ProteinModelPortali Q5RBS3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.036.

    Proteomic databases

    PRIDEi Q5RBS3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100172353.
    KEGGi pon:100172353.

    Organism-specific databases

    CTDi 871.

    Phylogenomic databases

    HOVERGENi HBG104930.
    KOi K09501.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiSERPH_PONAB
    AccessioniPrimary (citable) accession number: Q5RBS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3