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Protein

Serpin H1

Gene

SERPINH1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei376 – 377Reactive bond homologBy similarity2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Protein family/group databases

MEROPSiI04.036.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin H1
Alternative name(s):
Collagen-binding protein
Short name:
Colligin
Gene namesi
Name:SERPINH1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000025360519 – 417Serpin H1Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-succinyllysineBy similarity1
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Modified residuei141PhosphoserineBy similarity1
Modified residuei206N6-acetyllysineBy similarity1
Modified residuei295N6-succinyllysineBy similarity1
Modified residuei318N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ5RBS3.

Structurei

3D structure databases

ProteinModelPortaliQ5RBS3.
SMRiQ5RBS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi414 – 417Prevents secretion from ERPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 29Poly-Ala5

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG104930.
InParanoidiQ5RBS3.
KOiK09501.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
IPR033547. SERPINH1.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF27. PTHR11461:SF27. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RBS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLLLLSAF CLLEAALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL
60 70 80 90 100
AFSLYQAMAK DQAVENILVS PVVVASSLGL VSLGGKATTA SQAKAVLSAE
110 120 130 140 150
QLRDEEVHAG LGELLRSLSN STARNVTWKL GSRLYGPSSV SFADDFVRTA
160 170 180 190 200
SSTTTASTPR STSATSAALQ SINEWAAQTT DGKLPEVTKD VERTDGALLV
210 220 230 240 250
NAMFFKPHWD EKFHHKMVDN RGFMVTRSYT VGVMMMHRTG LYNYYDDEKE
260 270 280 290 300
KLQIVEMPLA HKLSSLIILM PHHVEPLERL EKLLTKEQLK IWMGKMQKKA
310 320 330 340 350
VAISLPKGVV EVTHDLQKHL AGLGLTEAID KNKADLSRMS GKKDLYLASV
360 370 380 390 400
FHATAFELDT DGNPFDQDIY GREELRSPKL FYADHPFIFL VRDTQSGSLL
410
FIGRLVRPKG DKMRDEL
Length:417
Mass (Da):45,762
Last modified:December 21, 2004 - v1
Checksum:iBF7BA00DAC59FEC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858522 mRNA. Translation: CAH90749.1.
CR858561 mRNA. Translation: CAH90787.1.
RefSeqiNP_001125445.1. NM_001131973.1.
UniGeneiPab.17407.

Genome annotation databases

GeneIDi100172353.
KEGGipon:100172353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858522 mRNA. Translation: CAH90749.1.
CR858561 mRNA. Translation: CAH90787.1.
RefSeqiNP_001125445.1. NM_001131973.1.
UniGeneiPab.17407.

3D structure databases

ProteinModelPortaliQ5RBS3.
SMRiQ5RBS3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI04.036.

Proteomic databases

PRIDEiQ5RBS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100172353.
KEGGipon:100172353.

Organism-specific databases

CTDi871.

Phylogenomic databases

HOVERGENiHBG104930.
InParanoidiQ5RBS3.
KOiK09501.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
IPR033547. SERPINH1.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF27. PTHR11461:SF27. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERPH_PONAB
AccessioniPrimary (citable) accession number: Q5RBS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.