ID   CDO1_PONAB              Reviewed;         200 AA.
AC   Q5RBQ7;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Cysteine dioxygenase type 1;
DE            EC=1.13.11.20;
DE   AltName: Full=Cysteine dioxygenase type I;
DE            Short=CDO-I;
DE            Short=CDO;
GN   Name=CDO1;
OS   Pongo abelii (Sumatran orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-cysteine + O(2) = 3-sulfinoalanine.
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- PATHWAY: Organosulfur biosynthesis; taurine biosynthesis;
CC       hypotaurine from L-cysteine: step 1/2.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- PTM: The thioether cross-link between Cys-93 and Tyr-157 plays a
CC       structural role through stabilizing the Fe(2+) ion, and prevents
CC       the production of highly damaging free hydroxyl radicals by
CC       holding the oxygen radical via hydroxyl hydrogen (By similarity).
CC   -!- SIMILARITY: Belongs to the cysteine dioxygenase family.
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DR   EMBL; CR858581; CAH90803.1; -; mRNA.
DR   RefSeq; NP_001127336.1; -.
DR   UniGene; Pab.12922; -.
DR   GeneID; 100174398; -.
DR   HOVERGEN; Q5RBQ7; -.
DR   OMA; Q5RBQ7; EWAAYAK.
DR   BRENDA; 1.13.11.20; 269192.
DR   GO; GO:0017172; F:cysteine dioxygenase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046439; P:L-cysteine metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR010300; Cys_dOase_I.
DR   Pfam; PF05995; CDO_I; 1.
PE   2: Evidence at transcript level;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phosphoprotein;
KW   Thioether bond.
FT   CHAIN         1    200       Cysteine dioxygenase type 1.
FT                                /FTId=PRO_0000206608.
FT   METAL        86     86       Iron; catalytic (By similarity).
FT   METAL        88     88       Iron; catalytic (By similarity).
FT   METAL       140    140       Iron; catalytic (By similarity).
FT   MOD_RES      59     59       Phosphothreonine (By similarity).
FT   CROSSLNK     93    157       3'-(S-cysteinyl)-tyrosine (Cys-Tyr) (By
FT                                similarity).
SQ   SEQUENCE   200 AA;  22972 MW;  E4EF87221D05C14D CRC64;
     MEQTEVLKPR TLADLIRILH QLFAGDEVNV EEVQAIMEAY ESDPTEWAMY AKFDQYRYTR
     NLVDQGNGKF NLMILCWGEG HGSSIHDHTN SHCFLKMLQG NLKETLFAWP DKKSNEMVKK
     SERVLRENQC AYINDSIGLH RVENISHTEP AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT
     FHSKFGIRTP NATSGSLENN
//