Q5RBQ7 (CDO1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteine dioxygenase type 1
EC=1.13.11.20

Alternative name(s):
Cysteine dioxygenase type I
Short name=CDO
Short name=CDO-I

Gene names

Name:

CDO1

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-cysteine + O2 = 3-sulfinoalanine.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Subunit structure	Monomer By similarity.
Post-translational modification	The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.
Sequence similarities	Belongs to the cysteine dioxygenase family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Thioether bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-cysteine metabolic process Inferred from electronic annotation. Source: InterPro taurine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara
Molecular_function	cysteine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	Cysteine dioxygenase type 1		PRO_0000206608
Sites
	Metal binding	86	1	Iron; catalytic By similarity
	Metal binding	88	1	Iron; catalytic By similarity
	Metal binding	140	1	Iron; catalytic By similarity
Amino acid modifications
	Cross-link	93 ↔ 157		3'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RBQ7 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: E4EF87221D05C14D	FASTA	200	22,972
	10 20 30 40 50 60 MEQTEVLKPR TLADLIRILH QLFAGDEVNV EEVQAIMEAY ESDPTEWAMY AKFDQYRYTR 70 80 90 100 110 120 NLVDQGNGKF NLMILCWGEG HGSSIHDHTN SHCFLKMLQG NLKETLFAWP DKKSNEMVKK 130 140 150 160 170 180 SERVLRENQC AYINDSIGLH RVENISHTEP AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT 190 200 FHSKFGIRTP NATSGSLENN

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR858581 mRNA. Translation: CAH90803.1.
RefSeq	NP_001127336.1. NM_001133864.1.
UniGene	Pab.12922.
3D structure databases
ProteinModelPortal	Q5RBQ7.
ModBase	Search...
Proteomic databases
PRIDE	Q5RBQ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000018267; ENSPPYP00000017558; ENSPPYG00000015698.
GeneID	100174398.
KEGG	pon:100174398.
Organism-specific databases
CTD	1036.
Phylogenomic databases
GeneTree	ENSGT00390000018226.
HOVERGEN	HBG004469.
InParanoid	Q5RBQ7.
KO	K00456.
OMA	KVAYIND.
Enzyme and pathway databases
UniPathway	UPA00012; UER00537.
Family and domain databases
Gene3D	2.60.120.10. 1 hit.
InterPro	IPR010300. Cys_dOase_I. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin. [Graphical view]
Pfam	PF05995. CDO_I. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDO1_PONAB

Accession

Primary (citable) accession number: Q5RBQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program