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Q5RBQ7

- CDO1_PONAB

UniProt

Q5RBQ7 - CDO1_PONAB

Protein

Cysteine dioxygenase type 1

Gene

CDO1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-cysteine + O2 = 3-sulfinoalanine.

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861Iron; catalyticBy similarity
    Metal bindingi88 – 881Iron; catalyticBy similarity
    Metal bindingi140 – 1401Iron; catalyticBy similarity

    GO - Molecular functioni

    1. cysteine dioxygenase activity Source: UniProtKB-EC
    2. iron ion binding Source: InterPro

    GO - Biological processi

    1. L-cysteine metabolic process Source: InterPro
    2. taurine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00012; UER00537.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine dioxygenase type 1 (EC:1.13.11.20)
    Alternative name(s):
    Cysteine dioxygenase type I
    Short name:
    CDO
    Short name:
    CDO-I
    Gene namesi
    Name:CDO1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 5

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Cysteine dioxygenase type 1PRO_0000206608Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki93 ↔ 1573'-(S-cysteinyl)-tyrosine (Cys-Tyr)By similarity

    Post-translational modificationi

    The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.By similarity

    Keywords - PTMi

    Thioether bond

    Proteomic databases

    PRIDEiQ5RBQ7.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RBQ7.
    SMRiQ5RBQ7. Positions 6-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cysteine dioxygenase family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000018226.
    HOVERGENiHBG004469.
    InParanoidiQ5RBQ7.
    KOiK00456.
    OMAiKMTFWSK.
    OrthoDBiEOG77M8PK.
    TreeFamiTF105636.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF05995. CDO_I. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5RBQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQTEVLKPR TLADLIRILH QLFAGDEVNV EEVQAIMEAY ESDPTEWAMY    50
    AKFDQYRYTR NLVDQGNGKF NLMILCWGEG HGSSIHDHTN SHCFLKMLQG 100
    NLKETLFAWP DKKSNEMVKK SERVLRENQC AYINDSIGLH RVENISHTEP 150
    AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT FHSKFGIRTP NATSGSLENN 200
    Length:200
    Mass (Da):22,972
    Last modified:December 21, 2004 - v1
    Checksum:iE4EF87221D05C14D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858581 mRNA. Translation: CAH90803.1.
    RefSeqiNP_001127336.1. NM_001133864.1.
    UniGeneiPab.12922.

    Genome annotation databases

    EnsembliENSPPYT00000018267; ENSPPYP00000017558; ENSPPYG00000015698.
    GeneIDi100174398.
    KEGGipon:100174398.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858581 mRNA. Translation: CAH90803.1 .
    RefSeqi NP_001127336.1. NM_001133864.1.
    UniGenei Pab.12922.

    3D structure databases

    ProteinModelPortali Q5RBQ7.
    SMRi Q5RBQ7. Positions 6-190.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5RBQ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000018267 ; ENSPPYP00000017558 ; ENSPPYG00000015698 .
    GeneIDi 100174398.
    KEGGi pon:100174398.

    Organism-specific databases

    CTDi 1036.

    Phylogenomic databases

    GeneTreei ENSGT00390000018226.
    HOVERGENi HBG004469.
    InParanoidi Q5RBQ7.
    KOi K00456.
    OMAi KMTFWSK.
    OrthoDBi EOG77M8PK.
    TreeFami TF105636.

    Enzyme and pathway databases

    UniPathwayi UPA00012 ; UER00537 .

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR010300. Cys_dOase_I.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF05995. CDO_I. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCDO1_PONAB
    AccessioniPrimary (citable) accession number: Q5RBQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3