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Q5RBQ7

- CDO1_PONAB

UniProt

Q5RBQ7 - CDO1_PONAB

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Protein
Cysteine dioxygenase type 1
Gene
CDO1
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Binds 1 iron ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron; catalytic By similarity
Metal bindingi88 – 881Iron; catalytic By similarity
Metal bindingi140 – 1401Iron; catalytic By similarity

GO - Molecular functioni

  1. cysteine dioxygenase activity Source: UniProtKB-EC
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. L-cysteine metabolic process Source: InterPro
  2. taurine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00012; UER00537.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase type 1 (EC:1.13.11.20)
Alternative name(s):
Cysteine dioxygenase type I
Short name:
CDO
Short name:
CDO-I
Gene namesi
Name:CDO1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Cysteine dioxygenase type 1
PRO_0000206608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki93 ↔ 1573'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Post-translational modificationi

The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.

Keywords - PTMi

Thioether bond

Proteomic databases

PRIDEiQ5RBQ7.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5RBQ7.
SMRiQ5RBQ7. Positions 6-190.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000018226.
HOVERGENiHBG004469.
InParanoidiQ5RBQ7.
KOiK00456.
OMAiKMTFWSK.
OrthoDBiEOG77M8PK.
TreeFamiTF105636.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5RBQ7-1 [UniParc]FASTAAdd to Basket

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MEQTEVLKPR TLADLIRILH QLFAGDEVNV EEVQAIMEAY ESDPTEWAMY    50
AKFDQYRYTR NLVDQGNGKF NLMILCWGEG HGSSIHDHTN SHCFLKMLQG 100
NLKETLFAWP DKKSNEMVKK SERVLRENQC AYINDSIGLH RVENISHTEP 150
AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT FHSKFGIRTP NATSGSLENN 200
Length:200
Mass (Da):22,972
Last modified:December 21, 2004 - v1
Checksum:iE4EF87221D05C14D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858581 mRNA. Translation: CAH90803.1.
RefSeqiNP_001127336.1. NM_001133864.1.
UniGeneiPab.12922.

Genome annotation databases

EnsembliENSPPYT00000018267; ENSPPYP00000017558; ENSPPYG00000015698.
GeneIDi100174398.
KEGGipon:100174398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858581 mRNA. Translation: CAH90803.1 .
RefSeqi NP_001127336.1. NM_001133864.1.
UniGenei Pab.12922.

3D structure databases

ProteinModelPortali Q5RBQ7.
SMRi Q5RBQ7. Positions 6-190.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5RBQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000018267 ; ENSPPYP00000017558 ; ENSPPYG00000015698 .
GeneIDi 100174398.
KEGGi pon:100174398.

Organism-specific databases

CTDi 1036.

Phylogenomic databases

GeneTreei ENSGT00390000018226.
HOVERGENi HBG004469.
InParanoidi Q5RBQ7.
KOi K00456.
OMAi KMTFWSK.
OrthoDBi EOG77M8PK.
TreeFami TF105636.

Enzyme and pathway databases

UniPathwayi UPA00012 ; UER00537 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF05995. CDO_I. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCDO1_PONAB
AccessioniPrimary (citable) accession number: Q5RBQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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