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Q5RBQ7 (CDO1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine dioxygenase type 1

EC=1.13.11.20
Alternative name(s):
Cysteine dioxygenase type I
Short name=CDO
Short name=CDO-I
Gene names
Name:CDO1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-cysteine + O2 = 3-sulfinoalanine.

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.

Subunit structure

Monomer By similarity.

Post-translational modification

The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen By similarity.

Sequence similarities

Belongs to the cysteine dioxygenase family.

Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   PTMThioether bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-cysteine metabolic process

Inferred from electronic annotation. Source: InterPro

taurine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytosol

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncysteine dioxygenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Cysteine dioxygenase type 1
PRO_0000206608

Sites

Metal binding861Iron; catalytic By similarity
Metal binding881Iron; catalytic By similarity
Metal binding1401Iron; catalytic By similarity

Amino acid modifications

Cross-link93 ↔ 1573'-(S-cysteinyl)-tyrosine (Cys-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5RBQ7 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: E4EF87221D05C14D

FASTA20022,972
        10         20         30         40         50         60 
MEQTEVLKPR TLADLIRILH QLFAGDEVNV EEVQAIMEAY ESDPTEWAMY AKFDQYRYTR 

        70         80         90        100        110        120 
NLVDQGNGKF NLMILCWGEG HGSSIHDHTN SHCFLKMLQG NLKETLFAWP DKKSNEMVKK 

       130        140        150        160        170        180 
SERVLRENQC AYINDSIGLH RVENISHTEP AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT 

       190        200 
FHSKFGIRTP NATSGSLENN 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR858581 mRNA. Translation: CAH90803.1.
RefSeqNP_001127336.1. NM_001133864.1.
UniGenePab.12922.

3D structure databases

ProteinModelPortalQ5RBQ7.
SMRQ5RBQ7. Positions 6-190.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5RBQ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000018267; ENSPPYP00000017558; ENSPPYG00000015698.
GeneID100174398.
KEGGpon:100174398.

Organism-specific databases

CTD1036.

Phylogenomic databases

GeneTreeENSGT00390000018226.
HOVERGENHBG004469.
InParanoidQ5RBQ7.
KOK00456.
OMAKMTFWSK.
OrthoDBEOG77M8PK.
TreeFamTF105636.

Enzyme and pathway databases

UniPathwayUPA00012; UER00537.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCDO1_PONAB
AccessionPrimary (citable) accession number: Q5RBQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways