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Protein

Cysteine dioxygenase type 1

Gene

CDO1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron; catalyticBy similarity
Metal bindingi88 – 881Iron; catalyticBy similarity
Metal bindingi140 – 1401Iron; catalyticBy similarity

GO - Molecular functioni

  1. cysteine dioxygenase activity Source: UniProtKB-EC
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. L-cysteine metabolic process Source: InterPro
  2. taurine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00012; UER00537.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine dioxygenase type 1 (EC:1.13.11.20)
Alternative name(s):
Cysteine dioxygenase type I
Short name:
CDO
Short name:
CDO-I
Gene namesi
Name:CDO1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Cysteine dioxygenase type 1PRO_0000206608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki93 ↔ 1573'-(S-cysteinyl)-tyrosine (Cys-Tyr)By similarity

Post-translational modificationi

The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.By similarity

Keywords - PTMi

Thioether bond

Proteomic databases

PRIDEiQ5RBQ7.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RBQ7.
SMRiQ5RBQ7. Positions 6-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine dioxygenase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000018226.
HOVERGENiHBG004469.
InParanoidiQ5RBQ7.
KOiK00456.
OMAiCFMKLLQ.
OrthoDBiEOG77M8PK.
TreeFamiTF105636.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5RBQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTEVLKPR TLADLIRILH QLFAGDEVNV EEVQAIMEAY ESDPTEWAMY
60 70 80 90 100
AKFDQYRYTR NLVDQGNGKF NLMILCWGEG HGSSIHDHTN SHCFLKMLQG
110 120 130 140 150
NLKETLFAWP DKKSNEMVKK SERVLRENQC AYINDSIGLH RVENISHTEP
160 170 180 190 200
AVSLHLYSPP FDTCHAFDQR TGHKNKVTMT FHSKFGIRTP NATSGSLENN
Length:200
Mass (Da):22,972
Last modified:December 20, 2004 - v1
Checksum:iE4EF87221D05C14D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858581 mRNA. Translation: CAH90803.1.
RefSeqiNP_001127336.1. NM_001133864.1.
UniGeneiPab.12922.

Genome annotation databases

EnsembliENSPPYT00000018267; ENSPPYP00000017558; ENSPPYG00000015698.
GeneIDi100174398.
KEGGipon:100174398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858581 mRNA. Translation: CAH90803.1.
RefSeqiNP_001127336.1. NM_001133864.1.
UniGeneiPab.12922.

3D structure databases

ProteinModelPortaliQ5RBQ7.
SMRiQ5RBQ7. Positions 6-190.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5RBQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000018267; ENSPPYP00000017558; ENSPPYG00000015698.
GeneIDi100174398.
KEGGipon:100174398.

Organism-specific databases

CTDi1036.

Phylogenomic databases

GeneTreeiENSGT00390000018226.
HOVERGENiHBG004469.
InParanoidiQ5RBQ7.
KOiK00456.
OMAiCFMKLLQ.
OrthoDBiEOG77M8PK.
TreeFamiTF105636.

Enzyme and pathway databases

UniPathwayiUPA00012; UER00537.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR010300. Cys_dOase_I.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF05995. CDO_I. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCDO1_PONAB
AccessioniPrimary (citable) accession number: Q5RBQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2005
Last sequence update: December 20, 2004
Last modified: January 6, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.