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Q5RBQ4

- UBP46_PONAB

UniProt

Q5RBQ4 - UBP46_PONAB

Protein

Ubiquitin carboxyl-terminal hydrolase 46

Gene

USP46

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441NucleophilePROSITE-ProRule annotation
    Active sitei313 – 3131Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. behavior Source: UniProtKB-KW
    2. protein deubiquitination Source: UniProtKB
    3. regulation of synaptic transmission, GABAergic Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Behavior, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.052.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 46 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 46
    Ubiquitin thioesterase 46
    Ubiquitin-specific-processing protease 46
    Gene namesi
    Name:USP46
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Ubiquitin carboxyl-terminal hydrolase 46PRO_0000304740Add
    BLAST

    Proteomic databases

    PRIDEiQ5RBQ4.

    Interactioni

    Subunit structurei

    Interacts with WDR48.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RBQ4.
    SMRiQ5RBQ4. Positions 36-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 365331USPAdd
    BLAST

    Sequence similaritiesi

    Contains 1 USP domain.Curated

    Phylogenomic databases

    HOGENOMiHOG000231498.
    HOVERGENiHBG054038.
    InParanoidiQ5RBN2.
    KOiK11842.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5RBQ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL    50
    QALYFCRPFR ENVLAYKAQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK 100
    KFISRLRKEN DLFDNYMQQD AHEFLNYLLN TIADILQEEK KQEKQNGKLK 150
    NGNMNEPAEN NKPELTWVHE IFQGTLTNET RCLNCETVSS KDEDFLDLSV 200
    DVEQNTSITH CLRDFSNTET LCSEQKYYCE TCCSKQEAQK RMRVKKLPMI 250
    LALHLKRFKY MEQLHRYTKL SYRVVFPLEL RLFNTSSDAV NLDRMYDLVA 300
    VVVHCGSGPN RGHYITIVKS HGFWLLFDDD IVEKIDAQAI EEFYGLTSDI 350
    SKNSESGYIL FYQSRE 366
    Length:366
    Mass (Da):42,442
    Last modified:December 21, 2004 - v1
    Checksum:i67BB113FC4081C46
    GO
    Isoform 2 (identifier: Q5RBQ4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         13-39: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:339
    Mass (Da):39,499
    Checksum:i29DA2DD25776A34E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei13 – 3927Missing in isoform 2. 1 PublicationVSP_037622Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858584 mRNA. Translation: CAH90806.1.
    CR858606 mRNA. Translation: CAH90828.1.
    RefSeqiNP_001127337.1. NM_001133865.1. [Q5RBQ4-1]
    NP_001128936.1. NM_001135464.1. [Q5RBQ4-2]
    UniGeneiPab.19798.

    Genome annotation databases

    GeneIDi100174399.
    100189895.
    KEGGipon:100174399.
    pon:100189895.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858584 mRNA. Translation: CAH90806.1 .
    CR858606 mRNA. Translation: CAH90828.1 .
    RefSeqi NP_001127337.1. NM_001133865.1. [Q5RBQ4-1 ]
    NP_001128936.1. NM_001135464.1. [Q5RBQ4-2 ]
    UniGenei Pab.19798.

    3D structure databases

    ProteinModelPortali Q5RBQ4.
    SMRi Q5RBQ4. Positions 36-366.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.052.

    Proteomic databases

    PRIDEi Q5RBQ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100174399.
    100189895.
    KEGGi pon:100174399.
    pon:100189895.

    Organism-specific databases

    CTDi 64854.

    Phylogenomic databases

    HOGENOMi HOG000231498.
    HOVERGENi HBG054038.
    InParanoidi Q5RBN2.
    KOi K11842.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney.

    Entry informationi

    Entry nameiUBP46_PONAB
    AccessioniPrimary (citable) accession number: Q5RBQ4
    Secondary accession number(s): Q5RBN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3