Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5RBQ1 (CP1A2_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A2

EC=1.14.14.1
Alternative name(s):
CYPIA2
Gene names
Name:CYP1A2
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 516515Cytochrome P450 1A2
PRO_0000232909

Sites

Metal binding4581Iron (heme axial ligand) By similarity
Binding site2261Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5RBQ1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 0767BBB3DC7BC9CC

FASTA51658,462
        10         20         30         40         50         60 
MALSQSVPFS ATELLLASAI FCLVFWVLKG LRPRVPKGLK SPPEPWGWPL LGHVLTLRKN 

        70         80         90        100        110        120 
PHLALSRMSQ RYGDVLQIRI GSTPVLVLSG LDTIRQALVR QGDDFKGRPD LYSSTLITDG 

       130        140        150        160        170        180 
QSLTFSPDSG PVWAARRHLA QNALNTFSIA SDPASSYSCY LEEHVSKEAE ALISRLQELM 

       190        200        210        220        230        240 
AGPGHFDPYN QVVVSVVNVI GAMCFGQHFP ESSDEMLSLV KNTHEFVETA SSGNPVDFFP 

       250        260        270        280        290        300 
ILRYLPNPAL QRFKAFNQRF LRFLRKTVQE HYQDFDKNSV QDIMGALFKY SKKGPRASGN 

       310        320        330        340        350        360 
LIPQEKIVNL VNDIFGAGFD TVTTAISWSL MYLVTKPEIQ RKIQKELDTM IGRGRRPRLS 

       370        380        390        400        410        420 
DRPQLPYLKA FILETFRHSS FLPFTIPHST TRDTTLNGFY IPKECCVFVN QWQVNHDPEL 

       430        440        450        460        470        480 
WEDPSEFWPE RFLTTDGTAI NKPLSEKVML FGMGKRRCIG EVLANWEVFL FLAILLQQLE 

       490        500        510 
FSVPPGVKVD LTPIYGLTMK HARCEHVQAR LRFSIK 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR858587 mRNA. Translation: CAH90809.1.
RefSeqNP_001125460.1. NM_001131988.1.
UniGenePab.12853.

3D structure databases

ProteinModelPortalQ5RBQ1.
SMRQ5RBQ1. Positions 34-514.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100172368.
KEGGpon:100172368.

Organism-specific databases

CTD1544.

Phylogenomic databases

HOVERGENHBG106944.
InParanoidQ5RBQ1.
KOK07409.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A2_PONAB
AccessionPrimary (citable) accession number: Q5RBQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: December 11, 2013
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families