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Q5RBQ1

- CP1A2_PONAB

UniProt

Q5RBQ1 - CP1A2_PONAB

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Protein
Cytochrome P450 1A2
Gene
CYP1A2
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei226 – 2261Substrate By similarity
Metal bindingi458 – 4581Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Gene namesi
Name:CYP1A2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 516515Cytochrome P450 1A2
PRO_0000232909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691O-linked (GlcNAc) By similarity

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5RBQ1.
SMRiQ5RBQ1. Positions 34-514.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.
InParanoidiQ5RBQ1.
KOiK07409.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RBQ1-1 [UniParc]FASTAAdd to Basket

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MALSQSVPFS ATELLLASAI FCLVFWVLKG LRPRVPKGLK SPPEPWGWPL    50
LGHVLTLRKN PHLALSRMSQ RYGDVLQIRI GSTPVLVLSG LDTIRQALVR 100
QGDDFKGRPD LYSSTLITDG QSLTFSPDSG PVWAARRHLA QNALNTFSIA 150
SDPASSYSCY LEEHVSKEAE ALISRLQELM AGPGHFDPYN QVVVSVVNVI 200
GAMCFGQHFP ESSDEMLSLV KNTHEFVETA SSGNPVDFFP ILRYLPNPAL 250
QRFKAFNQRF LRFLRKTVQE HYQDFDKNSV QDIMGALFKY SKKGPRASGN 300
LIPQEKIVNL VNDIFGAGFD TVTTAISWSL MYLVTKPEIQ RKIQKELDTM 350
IGRGRRPRLS DRPQLPYLKA FILETFRHSS FLPFTIPHST TRDTTLNGFY 400
IPKECCVFVN QWQVNHDPEL WEDPSEFWPE RFLTTDGTAI NKPLSEKVML 450
FGMGKRRCIG EVLANWEVFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK 500
HARCEHVQAR LRFSIK 516
Length:516
Mass (Da):58,462
Last modified:January 23, 2007 - v3
Checksum:i0767BBB3DC7BC9CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858587 mRNA. Translation: CAH90809.1.
RefSeqiNP_001125460.1. NM_001131988.1.
UniGeneiPab.12853.

Genome annotation databases

GeneIDi100172368.
KEGGipon:100172368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858587 mRNA. Translation: CAH90809.1 .
RefSeqi NP_001125460.1. NM_001131988.1.
UniGenei Pab.12853.

3D structure databases

ProteinModelPortali Q5RBQ1.
SMRi Q5RBQ1. Positions 34-514.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100172368.
KEGGi pon:100172368.

Organism-specific databases

CTDi 1544.

Phylogenomic databases

HOVERGENi HBG106944.
InParanoidi Q5RBQ1.
KOi K07409.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A2_PONAB
AccessioniPrimary (citable) accession number: Q5RBQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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