Reviewed, UniProtKB/Swiss-Prot Q5RBP7 (ADH1A_PONAB)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 1A
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase subunit alpha

Gene names

Name:

ADH1A

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Homodimer or heterodimer of closely related subunits By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 375	374	Alcohol dehydrogenase 1A		PRO_0000160660
Sites
	Metal binding	47	1	Zinc 1; catalytic By similarity
	Metal binding	68	1	Zinc 1; catalytic By similarity
	Metal binding	98	1	Zinc 2 By similarity
	Metal binding	101	1	Zinc 2 By similarity
	Metal binding	104	1	Zinc 2 By similarity
	Metal binding	112	1	Zinc 2 By similarity
	Metal binding	175	1	Zinc 1; catalytic By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RBP7-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 02F7A237894E4636	FASTA	375	39,622
	10 20 30 40 50 60 MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAQEVRIK MVAVGICGTD DHVVSGTMVT 70 80 90 100 110 120 PLPAILGHEA AGIVESVGEG VTTVKPGDKV IPLAVPQCGK CRICKNPESN YCLKNDVSNP 130 140 150 160 170 180 QGTLQDGTSR FTCRGKPIHH FLGISTFSQY TVVDENAVAK IDAASPLAKV CLIGCGFSTG 190 200 210 220 230 240 YGSAVNVAKV TPGSTCAVFG LGGVGLSVVM GCKAAGAARI IAVDINKDKF AKAKELGATE 250 260 270 280 290 300 CINPQDYNKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ 310 320 330 340 350 360 NLSMNPMLLL TGRTWKGAVL GGFKSKECVP KLVADFMAKK FSLDALITHV LPFEKINDGF 370 DLLHSGKSIR TILMF

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR858591 mRNA. Translation: CAH90813.1.
RefSeq	NP_001125462.1.
3D structure databases
SMR	Q5RBP7. Positions 1-374, 2-375.
ModBase	Search...
Genome annotation databases
GeneID	100172370.
Phylogenomic databases
HOVERGEN	Q5RBP7.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1A_PONAB

Accession

Primary (citable) accession number: Q5RBP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 31 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)