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Protein

Mimecan

Gene

OGN

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.By similarity

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Mimecan
Alternative name(s):
Osteoglycin
Gene namesi
Name:OGN
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 298278MimecanPRO_0000240315Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi255 ↔ 288By similarity
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000021715.

Structurei

3D structure databases

ProteinModelPortaliQ5RBL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati112 – 13120LRR 1Add
BLAST
Repeati132 – 15524LRR 2Add
BLAST
Repeati156 – 17924LRR 3Add
BLAST
Repeati180 – 19920LRR 4Add
BLAST
Repeati200 – 22526LRR 5Add
BLAST
Repeati226 – 24621LRR 6Add
BLAST
Repeati247 – 27731LRR 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi94 – 10613Cys-richAdd
BLAST

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110781.
HOVERGENiHBG006850.
InParanoidiQ5RBL2.
KOiK08126.
OMAiDTRYIRD.
OrthoDBiEOG75TMD0.
TreeFamiTF351924.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24373:SF122. PTHR24373:SF122. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RBL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLQSTLLL LLFVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK
60 70 80 90 100
YLDGKNIKEK ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL
110 120 130 140 150
SGSVYCEEVD IDAVPPLPKE SAYLYARFNK IKKLTAKDFA DIPNLRRLDF
160 170 180 190 200
TGNLIEDIED GTFSKLSLLE ELSLAENQLL KLPVLPPKLT LFNAKYNKIK
210 220 230 240 250
SRGIKANAFK KLNNLTFLYL DHNALESVPL NLPESLRVIH LQFNNIASIT
260 270 280 290
DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYF
Length:298
Mass (Da):33,956
Last modified:December 21, 2004 - v1
Checksum:i2F3F21C7A186178B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858628 mRNA. Translation: CAH90848.1.
RefSeqiNP_001125484.1. NM_001132012.1.
UniGeneiPab.3708.

Genome annotation databases

EnsembliENSPPYT00000022602; ENSPPYP00000021715; ENSPPYG00000019377.
GeneIDi100172393.
KEGGipon:100172393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858628 mRNA. Translation: CAH90848.1.
RefSeqiNP_001125484.1. NM_001132012.1.
UniGeneiPab.3708.

3D structure databases

ProteinModelPortaliQ5RBL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000021715.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000022602; ENSPPYP00000021715; ENSPPYG00000019377.
GeneIDi100172393.
KEGGipon:100172393.

Organism-specific databases

CTDi4969.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110781.
HOVERGENiHBG006850.
InParanoidiQ5RBL2.
KOiK08126.
OMAiDTRYIRD.
OrthoDBiEOG75TMD0.
TreeFamiTF351924.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR027211. Mimecan.
[Graphical view]
PANTHERiPTHR24373:SF122. PTHR24373:SF122. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiMIME_PONAB
AccessioniPrimary (citable) accession number: Q5RBL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.