Reviewed, UniProtKB/Swiss-Prot Q5RBB9 (NQO2_PONAB)

Names and origin

Protein names

Recommended name:
    Ribosyldihydronicotinamide dehydrogenase [quinone]
    EC=1.10.99.2
Alternative name(s):
    NRH dehydrogenase [quinone] 2
    NRH:quinone oxidoreductase 2
    Quinone reductase 2
      Short name=QR2

Gene names

Name:

NQO2

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis By similarity.
Catalytic activity	1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.
Cofactor	Binds 1 zinc ion per subunit By similarity. FAD By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.
Sequence similarities	Belongs to the NAD(P)H dehydrogenase (quinone) family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein Metal-binding Zinc
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro dihydronicotinamide riboside quinone reductase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 231	230	Ribosyldihydronicotinamide dehydrogenase [quinone]		PRO_0000071628
Regions
	Nucleotide binding	18 – 21	4	FAD By similarity
	Nucleotide binding	104 – 107	4	FAD By similarity
	Nucleotide binding	148 – 151	4	FAD By similarity
	Region	127 – 129	3	Substrate binding By similarity
Sites
	Metal binding	174	1	Zinc By similarity
	Metal binding	178	1	Zinc By similarity
	Metal binding	223	1	Zinc By similarity
	Binding site	12	1	FAD By similarity
	Binding site	156	1	FAD By similarity
	Binding site	194	1	FAD By similarity
	Binding site	201	1	FAD By similarity
Amino acid modifications
	Modified residue	31	1	Phosphoserine By similarity
	Modified residue	80	1	Phosphoserine By similarity
	Modified residue	197	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RBB9-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 2CAD61FD15A415DA	FASTA	231	26,144
	10 20 30 40 50 60 MAGKKVLIVY AHQEPRSFNG SLKNVAVDEL SRQGCTVTVS DLYAMNFEPR ATKKDITGAL 70 80 90 100 110 120 SNPEVFHYGV ETHEAYKQRS LASDITDEQK KVQEADLVIF QFPLYWFSVP AILKGWMDRV 130 140 150 160 170 180 LCQGFAFDIP GFYDSGLLQG KLALLSVTTG GTAEMYTKTG VNGDFRYFLW PLQHGTLHFC 190 200 210 220 230 GFKVLAPQIS FAPEIASEEE RKGMVAAWSQ RLQTIWKEEP IPCTAHWYFR Q

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR858732 mRNA. Translation: CAH90941.1.
RefSeq	NP_001127353.1.
UniGene	Pab.13785
3D structure databases
SMR	Q5RBB9. Positions 2-231.
ModBase	Search...
Genome annotation databases
GeneID	100174417.
Organism-specific databases
CTD	100174417.
Phylogenomic databases
HOVERGEN	Q5RBB9.
InParanoid	Q5RBB9.
Enzyme and pathway databases
BRENDA	1.10.99.2. 269192.
Family and domain databases
InterPro	IPR003680. Flavodoxin_fold. [Graphical view]
Pfam	PF02525. Flavodoxin_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NQO2_PONAB

Accession

Primary (citable) accession number: Q5RBB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	January 23, 2007
Last modified:	February 9, 2010
This is version 32 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)