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Q5RB02

- CATC_PONAB

UniProt

Q5RB02 - CATC_PONAB

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Protein

Dipeptidyl peptidase 1

Gene

CTSC

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function (By similarity).By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

Cofactori

Binds 1 chloride ion per heavy chain.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei258 – 2581By similarity
Binding sitei302 – 3021ChlorideBy similarity
Binding sitei304 – 3041Chloride; via amide nitrogenBy similarity
Binding sitei347 – 3471ChlorideBy similarity
Active sitei405 – 4051By similarity
Active sitei427 – 4271By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Chloride

Protein family/group databases

MEROPSiC01.070.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 1 (EC:3.4.14.1)
Alternative name(s):
Cathepsin C
Cathepsin J
Dipeptidyl peptidase I
Short name:
DPP-I
Short name:
DPPI
Dipeptidyl transferase
Cleaved into the following 3 chains:
Alternative name(s):
Dipeptidyl peptidase I exclusion domain chain
Alternative name(s):
Dipeptidyl peptidase I heavy chain
Alternative name(s):
Dipeptidyl peptidase I light chain
Gene namesi
Name:CTSC
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 134110Dipeptidyl peptidase 1 exclusion domain chainPRO_0000260307Add
BLAST
Propeptidei135 – 23096By similarityPRO_0000260308Add
BLAST
Chaini231 – 394164Dipeptidyl peptidase 1 heavy chainBy similarityPRO_0000260309Add
BLAST
Chaini395 – 46369Dipeptidyl peptidase 1 light chainBy similarityPRO_0000260310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Zymogen

Interactioni

Subunit structurei

Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RB02.
SMRiQ5RB02. Positions 25-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005248.
InParanoidiQ5RB02.
KOiK01275.

Family and domain databases

Gene3Di2.40.128.80. 1 hit.
InterProiIPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
SUPFAMiSSF75001. SSF75001. 1 hit.
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RB02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPGPASLLA ALLLLLSGDR AVRCDTPANC TYLDLLGTWV FQVGSSGSQR
60 70 80 90 100
DVNCSVMGPQ EKKVVVHLQK LDTAYDDLGN SGHFTIIYNQ GFEIVLNDYK
110 120 130 140 150
WFAFFKYKEE GSKVTTYCNE TMTGWVHDVL GRNWACFTGK KVGTASENVY
160 170 180 190 200
VNTAHLKNSQ EKYSNRLYKY DHNFVKAINA IQKSWTATTY KEYETLTLGD
210 220 230 240 250
MIRRSGGHSR KIPRPKPAPL TAEIQQKVLH LPTSWDWRNI HGINFVSPVR
260 270 280 290 300
NQASCGSCYS FASMGMLEAR IRILTSNSQT PILSPQEVVS CSQYAQGCEG
310 320 330 340 350
GFPYLIAGKY AQDFGLVEEA CFPYTGTDSP CKMKEDCFRY YSSEYHYVGG
360 370 380 390 400
FYGGCNEALM KLELVHHGPM AVAFEVYDDF LHYKKGIYHH TGLRDPFNPF
410 420 430 440 450
ELTNHAVLLV GYGTDSASGM DYWIVKNSWG TGWGEDGYFR IRRGTDECAI
460
ESIAVAATPI PKL
Length:463
Mass (Da):51,870
Last modified:December 21, 2004 - v1
Checksum:iEAB7D3A7CF82C09E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858858 mRNA. Translation: CAH91058.1.
RefSeqiNP_001125612.1. NM_001132140.1.

Genome annotation databases

GeneIDi100172530.
KEGGipon:100172530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR858858 mRNA. Translation: CAH91058.1 .
RefSeqi NP_001125612.1. NM_001132140.1.

3D structure databases

ProteinModelPortali Q5RB02.
SMRi Q5RB02. Positions 25-463.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C01.070.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100172530.
KEGGi pon:100172530.

Organism-specific databases

CTDi 1075.

Phylogenomic databases

HOVERGENi HBG005248.
InParanoidi Q5RB02.
KOi K01275.

Family and domain databases

Gene3Di 2.40.128.80. 1 hit.
InterProi IPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00645. Pept_C1. 1 hit.
[Graphical view ]
SUPFAMi SSF75001. SSF75001. 1 hit.
PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiCATC_PONAB
AccessioniPrimary (citable) accession number: Q5RB02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3