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Q5RB02

- CATC_PONAB

UniProt

Q5RB02 - CATC_PONAB

Protein

Dipeptidyl peptidase 1

Gene

CTSC

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

    Cofactori

    Binds 1 chloride ion per heavy chain.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei258 – 2581By similarity
    Binding sitei302 – 3021ChlorideBy similarity
    Binding sitei304 – 3041Chloride; via amide nitrogenBy similarity
    Binding sitei347 – 3471ChlorideBy similarity
    Active sitei405 – 4051By similarity
    Active sitei427 – 4271By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Ligandi

    Chloride

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidyl peptidase 1 (EC:3.4.14.1)
    Alternative name(s):
    Cathepsin C
    Cathepsin J
    Dipeptidyl peptidase I
    Short name:
    DPP-I
    Short name:
    DPPI
    Dipeptidyl transferase
    Cleaved into the following 3 chains:
    Alternative name(s):
    Dipeptidyl peptidase I exclusion domain chain
    Alternative name(s):
    Dipeptidyl peptidase I heavy chain
    Alternative name(s):
    Dipeptidyl peptidase I light chain
    Gene namesi
    Name:CTSC
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 134110Dipeptidyl peptidase 1 exclusion domain chainPRO_0000260307Add
    BLAST
    Propeptidei135 – 23096By similarityPRO_0000260308Add
    BLAST
    Chaini231 – 394164Dipeptidyl peptidase 1 heavy chainBy similarityPRO_0000260309Add
    BLAST
    Chaini395 – 46369Dipeptidyl peptidase 1 light chainBy similarityPRO_0000260310Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Zymogen

    Interactioni

    Subunit structurei

    Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RB02.
    SMRiQ5RB02. Positions 25-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG005248.
    InParanoidiQ5RB02.
    KOiK01275.

    Family and domain databases

    Gene3Di2.40.128.80. 1 hit.
    InterProiIPR014882. CathepsinC_exc.
    IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08773. CathepsinC_exc. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00645. Pept_C1. 1 hit.
    [Graphical view]
    SUPFAMiSSF75001. SSF75001. 1 hit.
    PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5RB02-1 [UniParc]FASTAAdd to Basket

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    MGPGPASLLA ALLLLLSGDR AVRCDTPANC TYLDLLGTWV FQVGSSGSQR    50
    DVNCSVMGPQ EKKVVVHLQK LDTAYDDLGN SGHFTIIYNQ GFEIVLNDYK 100
    WFAFFKYKEE GSKVTTYCNE TMTGWVHDVL GRNWACFTGK KVGTASENVY 150
    VNTAHLKNSQ EKYSNRLYKY DHNFVKAINA IQKSWTATTY KEYETLTLGD 200
    MIRRSGGHSR KIPRPKPAPL TAEIQQKVLH LPTSWDWRNI HGINFVSPVR 250
    NQASCGSCYS FASMGMLEAR IRILTSNSQT PILSPQEVVS CSQYAQGCEG 300
    GFPYLIAGKY AQDFGLVEEA CFPYTGTDSP CKMKEDCFRY YSSEYHYVGG 350
    FYGGCNEALM KLELVHHGPM AVAFEVYDDF LHYKKGIYHH TGLRDPFNPF 400
    ELTNHAVLLV GYGTDSASGM DYWIVKNSWG TGWGEDGYFR IRRGTDECAI 450
    ESIAVAATPI PKL 463
    Length:463
    Mass (Da):51,870
    Last modified:December 21, 2004 - v1
    Checksum:iEAB7D3A7CF82C09E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858858 mRNA. Translation: CAH91058.1.
    RefSeqiNP_001125612.1. NM_001132140.1.

    Genome annotation databases

    GeneIDi100172530.
    KEGGipon:100172530.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR858858 mRNA. Translation: CAH91058.1 .
    RefSeqi NP_001125612.1. NM_001132140.1.

    3D structure databases

    ProteinModelPortali Q5RB02.
    SMRi Q5RB02. Positions 25-463.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100172530.
    KEGGi pon:100172530.

    Organism-specific databases

    CTDi 1075.

    Phylogenomic databases

    HOVERGENi HBG005248.
    InParanoidi Q5RB02.
    KOi K01275.

    Family and domain databases

    Gene3Di 2.40.128.80. 1 hit.
    InterProi IPR014882. CathepsinC_exc.
    IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08773. CathepsinC_exc. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75001. SSF75001. 1 hit.
    PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiCATC_PONAB
    AccessioniPrimary (citable) accession number: Q5RB02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3