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Protein

Dymeclin

Gene

DYM

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Necessary for correct organization of Golgi apparatus. Involved in bone development.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Dymeclin
Gene namesi
Name:DYM
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm
  • Golgi apparatus By similarity
  • Membrane By similarity; Lipid-anchor By similarity

  • Note: Sequence analysis programs predict 1 transmembrane region. However, it has been shown in human that it is not a stably anchored transmembrane protein but it weakly associates with the Golgi apparatus and shuttles between the Golgi and the cytosol (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 669668DymeclinPRO_0000086885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Post-translational modificationi

Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment.By similarity

Keywords - PTMi

Lipoprotein, Myristate

Interactioni

Subunit structurei

Interacts with GOLM1 and PPIB.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000010279.

Family & Domainsi

Sequence similaritiesi

Belongs to the dymeclin family.Curated

Phylogenomic databases

eggNOGiKOG2225. Eukaryota.
ENOG410XP0J. LUCA.
HOVERGENiHBG057356.
InParanoidiQ5RAW5.

Family and domain databases

InterProiIPR019142. Dymeclin.
[Graphical view]
PANTHERiPTHR12895:SF9. PTHR12895:SF9. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RAW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNSSRIGD LPKNQYLKKL SGTESISEND PFWNQLLSFS FPAPTSSTEL
60 70 80 90 100
KLLEEATISV CRSLVENNPR TGNLGALIKV FLSRTKELKL SAECQNHIFI
110 120 130 140 150
WQTHNALFII CCLLKVFICQ MSEEELQLHF TYEEKSPGNY SSDSEDLLEE
160 170 180 190 200
LLCCLMQLIT DIPLLDITYE ISVEAISTMV VFLSCQLFHK EVLRQSISHK
210 220 230 240 250
YLMRGPCLPY TSKLVKTLLY NFIRQEKPPP PGAHVFPQQS DGGGLLYGLA
260 270 280 290 300
SGVATGLWTV FTLGGVGSKV AASPELSSPL ANQSLLLLLV LANLTDASDA
310 320 330 340 350
PNPYRQAIMS FKNTQDSSPF PPLIPHAFQI NFNSLYTALC EQQTSDQATL
360 370 380 390 400
LLYTLLHQNS NIRTYMLART DMENLVLPIL EILYHVEERN SHHVYMALII
410 420 430 440 450
LLILTEDDGF NRSIHEVILK NITWYSERVL TEISLGSLLI LVVIRTIQYN
460 470 480 490 500
MTRTRDKYLH TNCLAALANM SAQFRSLHQY AAQRIISLFS LLSKKHNKVL
510 520 530 540 550
EQATQSLRGS LSSNDVPLPD YAQDLNVIEE VIRMMLEIIN SCLTNSLHHN
560 570 580 590 600
PNLVYALLYK RDLFEQFRTH PSFQDIMQNI DLVITFFSSR LLQAGAELSV
610 620 630 640 650
ERVLEIIKQG VVALPKDRLK KFPELKFKYV EEEQPEEFFI PYVWSLVYNS
660
AVGLYWNPQD IQLFTMDSD
Length:669
Mass (Da):76,027
Last modified:December 21, 2004 - v1
Checksum:iEE55118F323BA5BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858896 mRNA. Translation: CAH91095.1.
RefSeqiNP_001127375.1. NM_001133903.1.
UniGeneiPab.7444.

Genome annotation databases

GeneIDi100174440.
KEGGipon:100174440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858896 mRNA. Translation: CAH91095.1.
RefSeqiNP_001127375.1. NM_001133903.1.
UniGeneiPab.7444.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000010279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100174440.
KEGGipon:100174440.

Organism-specific databases

CTDi54808.

Phylogenomic databases

eggNOGiKOG2225. Eukaryota.
ENOG410XP0J. LUCA.
HOVERGENiHBG057356.
InParanoidiQ5RAW5.

Family and domain databases

InterProiIPR019142. Dymeclin.
[Graphical view]
PANTHERiPTHR12895:SF9. PTHR12895:SF9. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDYM_PONAB
AccessioniPrimary (citable) accession number: Q5RAW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: January 20, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.