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Reviewed, UniProtKB/Swiss-Prot Q5RAU0 (ACOX3_PONAB)

Last modified June 16, 2009. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Peroxisomal acyl-coenzyme A oxidase 3
    EC=1.3.3.6
Alternative name(s):
    Pristanoyl-CoA oxidase
    Branched-chain acyl-CoA oxidase
      Short name=BRCACox
Gene names
Name: ACOX3
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

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Protein attributes

Sequence length700 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Oxidizes the CoA-esters of 2-methyl-branched fatty acids By similarity.

Catalytic activity

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactor

FAD By similarity.

Pathway

Lipid metabolism; peroxisomal fatty acid beta-oxidation.

Subcellular location

Peroxisome Potential.

Sequence similarities

Belongs to the acyl-CoA oxidase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 700700Peroxisomal acyl-coenzyme A oxidase 3
PRO_0000290353

Regions

Motif698 – 7003Microbody targeting signal By similarity
Compositional bias340 – 3434Poly-Glu

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Sequences

Sequence LengthMass (Da)Tools
Q5RAU0-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: C405A0D65A2796E5

FASTA70077,865
        10         20         30         40         50         60 
MASTVEGGDT ALLPEFPGGP LDAYRARASF SWKELALFTE GEDMLRFKKT IFSALENDPL 

        70         80         90        100        110        120 
FARSPGADLS LEKYRELNFL RCRRIFEYDF LSVEDMFKSP LKVLTLIQCL GMYDSSLAAK 

       130        140        150        160        170        180 
YLIHSLVFGS AIYSSGSERH LTYIQKIFRM EIFGCFALTE LSHGSNTKAI RTTAHYDPAT 

       190        200        210        220        230        240 
EEFIIHSPDF EAAKFWVGNM GKTATHAVVF AKLYVPGDQC HGLHPFIVQI RDSKTLLPMP 

       250        260        270        280        290        300 
GVMVGDIGKK LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSSF KDVRQHFGAT 

       310        320        330        340        350        360 
LGSLSWSRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP MQQWRLLPYL 

       370        380        390        400        410        420 
AAIYALDHFS KSLFLDLMEL QQGLASGDRS ARQAELGREI HALASASKPL ASWTTQQGIQ 

       430        440        450        460        470        480 
ECREACGGHG YLAMNRLGVL RDDNDPNCTY EGDNNILLQQ TSNYLLGLLA HQVQDGACFR 

       490        500        510        520        530        540 
SPLKSVDFLD AYPGILDQKF EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG 

       550        560        570        580        590        600 
SSDFEARNKC QVSHGRPLAL AFVELTVVQR FHEHVHQPCV PPSLRAVLGR LSALYALWSL 

       610        620        630        640        650        660 
SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFI LDSPIGRADG 

       670        680        690        700 
ELYKNLWGAI LQESKALERA SWWPEFSVNK PVIGSLKSKL

« Hide

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References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

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Cross-references

Sequence databases

CR858922 mRNA. Translation: CAH91120.1.
RefSeqNP_001125655.1.
UniGenePab.10099

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID100172575.

Phylogenomic databases

HOVERGENQ5RAU0.

Enzyme and pathway databases

BRENDA1.3.3.6. 269192.

Family and domain databases

InterProIPR006090. Acyl-CoA_Oxase/DH_1.
IPR006091. Acyl-CoA_Oxase/DH_M.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR013764. AcylCoA_oxidase/DH_1/2_C.
[Graphical view]
Gene3DG3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit.
G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit.
G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHERPTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
PfamPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFPIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameACOX3_PONAB
AccessionPrimary (citable) accession number: Q5RAU0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 21, 2004
Last modified: June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents