Reviewed, UniProtKB/Swiss-Prot Q5RAU0 (ACOX3_PONAB)

Names and origin

Protein names

Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 3
    EC=1.3.3.6
Alternative name(s):
    Pristanoyl-CoA oxidase
    Branched-chain acyl-CoA oxidase
      Short name=BRCACox

Gene names

Name:

ACOX3

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	700 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Oxidizes the CoA-esters of 2-methyl-branched fatty acids By similarity.
Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD By similarity.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subcellular location	Peroxisome Potential.
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 700	700	Peroxisomal acyl-coenzyme A oxidase 3		PRO_0000290353
Regions
	Motif	698 – 700	3	Microbody targeting signal By similarity
	Compositional bias	340 – 343	4	Poly-Glu
Amino acid modifications
	Modified residue	281	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RAU0-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: C405A0D65A2796E5	FASTA	700	77,865
	10 20 30 40 50 60 MASTVEGGDT ALLPEFPGGP LDAYRARASF SWKELALFTE GEDMLRFKKT IFSALENDPL 70 80 90 100 110 120 FARSPGADLS LEKYRELNFL RCRRIFEYDF LSVEDMFKSP LKVLTLIQCL GMYDSSLAAK 130 140 150 160 170 180 YLIHSLVFGS AIYSSGSERH LTYIQKIFRM EIFGCFALTE LSHGSNTKAI RTTAHYDPAT 190 200 210 220 230 240 EEFIIHSPDF EAAKFWVGNM GKTATHAVVF AKLYVPGDQC HGLHPFIVQI RDSKTLLPMP 250 260 270 280 290 300 GVMVGDIGKK LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSSF KDVRQHFGAT 310 320 330 340 350 360 LGSLSWSRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP MQQWRLLPYL 370 380 390 400 410 420 AAIYALDHFS KSLFLDLMEL QQGLASGDRS ARQAELGREI HALASASKPL ASWTTQQGIQ 430 440 450 460 470 480 ECREACGGHG YLAMNRLGVL RDDNDPNCTY EGDNNILLQQ TSNYLLGLLA HQVQDGACFR 490 500 510 520 530 540 SPLKSVDFLD AYPGILDQKF EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG 550 560 570 580 590 600 SSDFEARNKC QVSHGRPLAL AFVELTVVQR FHEHVHQPCV PPSLRAVLGR LSALYALWSL 610 620 630 640 650 660 SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFI LDSPIGRADG 670 680 690 700 ELYKNLWGAI LQESKALERA SWWPEFSVNK PVIGSLKSKL

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR858922 mRNA. Translation: CAH91120.1.
RefSeq	NP_001125655.1.
UniGene	Pab.10099
3D structure databases
HSSP	HSSP built from PDB template 2DDH based on UniProtKB P07872.
ModBase	Search...
Genome annotation databases
GeneID	100172575.
Organism-specific databases
CTD	100172575.
Phylogenomic databases
HOVERGEN	Q5RAU0.
Enzyme and pathway databases
BRENDA	1.3.3.6. 269192.
Family and domain databases
InterPro	IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_cen-dom. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR009075. AcylCo_DH/oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR009100. AcylCoA_DH/oxidase. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACOX3_PONAB

Accession

Primary (citable) accession number: Q5RAU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	December 21, 2004
Last modified:	February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)