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Q5RAN0 (ACVL1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase receptor R3

Short name=SKR3
EC=2.7.11.30
Alternative name(s):
Activin receptor-like kinase 1
Short name=ALK-1
Gene names
Name:ACVRL1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well By similarity.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 503482Serine/threonine-protein kinase receptor R3
PRO_0000234418

Regions

Topological domain22 – 11897Extracellular Potential
Transmembrane119 – 14123Helical; Potential
Topological domain142 – 503362Cytoplasmic Potential
Domain172 – 20130GS
Domain202 – 492291Protein kinase
Nucleotide binding208 – 2169ATP By similarity
Region73 – 764Mediates specificity for BMP ligand By similarity

Sites

Active site3301Proton acceptor By similarity
Binding site2291ATP By similarity

Amino acid modifications

Modified residue1551Phosphoserine By similarity
Glycosylation981N-linked (GlcNAc...) Potential
Disulfide bond34 ↔ 51 By similarity
Disulfide bond36 ↔ 41 By similarity
Disulfide bond46 ↔ 69 By similarity
Disulfide bond77 ↔ 89 By similarity
Disulfide bond90 ↔ 95 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5RAN0 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 8339B39C42688060

FASTA50356,200
        10         20         30         40         50         60 
MTLGSPRRGL LMLLMALVTQ GDPVKPSRGP LVTCTCESPH CRGPTCRGAW CTVVLVREEG 

        70         80         90        100        110        120 
RHPQEHRGCG NLHRELCRGR PTEFVNHYCC DSHLCNHNVS LVLEATQSPS EQPGTDGQLA 

       130        140        150        160        170        180 
LILGPVLALL ALVALGVLGL WHVRRRQEKQ RGLHSELGES SLILKASEQG DSMLGDLLDS 

       190        200        210        220        230        240 
DCTTGSGSGL PFLVQRTVAR QVALVECVGK GRYGEVWRGL WHGESVAVKI FSSRDEQSWF 

       250        260        270        280        290        300 
RETEIYNTVL LRHDNILGFI ASDMTSRNSS TQLWLITHYH EHGSLYDFLQ RQTLEPHLAL 

       310        320        330        340        350        360 
RLTVSAACGL AHLHVEIFGT QGKPAIAHRD FKSRNVLVKS NLQCCIADLG LAVMHSQGSD 

       370        380        390        400        410        420 
YLDIGNNPRV GTKRYMAPEV LDEQIRTDCF ESYKWTDIWA FGLVLWEIAR RTIVNGIVED 

       430        440        450        460        470        480 
YRPPFYDVVP NDPSFEDMKK VVCVDQQTPT IPNRLAADPV LSGLAQMMRE CWYPNPSARL 

       490        500 
TALRIKKTLQ KISNSPEKPK VIQ 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR858985 mRNA. Translation: CAH91180.1.
RefSeqNP_001125692.1. NM_001132220.1.

3D structure databases

ProteinModelPortalQ5RAN0.
SMRQ5RAN0. Positions 172-493.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100172614.
KEGGpon:100172614.

Organism-specific databases

CTD94.

Phylogenomic databases

HOVERGENHBG054502.
KOK13594.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255. PTHR23255. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
SMARTSM00467. GS. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACVL1_PONAB
AccessionPrimary (citable) accession number: Q5RAN0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families