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Q5RAL7 (B3GL1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
Short name=Beta-1,3-GalNAc-T1
EC=2.4.1.79
Alternative name(s):
Beta-1,3-galactosyltransferase 3
Short name=Beta-1,3-GalTase 3
Short name=Beta3Gal-T3
Short name=Beta3GalT3
Short name=b3Gal-T3
Beta-3-Gx-T3
Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
Globoside synthase
UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
Gene names
Name:B3GALNT1
Synonyms:B3GALT3
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transfers N-acetylgalactosamine onto globotriaosylceramide By similarity.

Catalytic activity

UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Cofactor

Magnesium By similarity.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 31 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
PRO_0000219157

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4323Helical; Signal-anchor for type II membrane protein; Potential
Topological domain44 – 331288Lumenal Potential

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation3261N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5RAL7 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: B1E123188579B585

FASTA33139,478
        10         20         30         40         50         60 
MASALWTVLP SRMSLRSLQW SLLLLSLLSF LVMWYLSLPH YNVIERVNWM YFYEYEPIYR 

        70         80         90        100        110        120 
QDFHFTLREH SNCSHQNPFL VILVTSHPSD VKARQAIRVT WGEKKSWWGY EVLTFFLLGQ 

       130        140        150        160        170        180 
EAEKEDKMLA LSLEDEHLLY GDIIRQDFLD TYNNLTLKTI MAFRWVTEFC PNAKYVMKTD 

       190        200        210        220        230        240 
TDVFINTGNL VKYLLNLNHS EKFFTGYPLI DNYSYRGFYQ KTHISYQEYP FKVFPPYCSG 

       250        260        270        280        290        300 
LGYIMSRDLV PRIYEMMGHV KPIKFEDVYV GICLNLLKVN IHIPEDTNLF FLYRIHLDVC 

       310        320        330 
QLRRVIAAHG FSSKEIITFW QVMLRNTTCH Y

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR858998 mRNA. Translation: CAH91193.1.
RefSeqNP_001127386.1. NM_001133914.1.
UniGenePab.19103.

3D structure databases

ProteinModelPortalQ5RAL7.
ModBaseSearch...

Protein family/group databases

CAZyGT31. Glycosyltransferase Family 31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100174453.
KEGGpon:100174453.

Organism-specific databases

CTD8706.

Phylogenomic databases

HOVERGENHBG101817.
InParanoidQ5RAL7.
KOK00719.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERPTHR11214. PTHR11214. 1 hit.
PfamPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3GL1_PONAB
AccessionPrimary (citable) accession number: Q5RAL7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: March 6, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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