Q5RAH9 (BIRC5_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Baculoviral IAP repeat-containing protein 5

Alternative name(s):
Apoptosis inhibitor survivin

Gene names

Name:

BIRC5

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7 By similarity.
Subunit structure	Monomer or homodimer. Exist as a homodimer in the apo state and as a monomer in the CPC-bound state By similarity. When phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with JTB. Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Chromosome › centromere By similarity. Cytoplasm › cytoskeleton › spindle By similarity. Note: Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes By similarity.
Domain	The BIR repeat is necessary and sufficient for HBXIP binding By similarity.
Post-translational modification	Ubiquitination is required for centrosomal targeting By similarity. In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes By similarity.
Sequence similarities	Belongs to the IAP family. Contains 1 BIR repeat.

Ontologies

Keywords
Biological process	Apoptosis Cell cycle Cell division Chromosome partition Mitosis
Cellular component	Centromere Chromosome Cytoplasm Cytoskeleton Nucleus
Ligand	Metal-binding Zinc
Molecular function	Protease inhibitor Thiol protease inhibitor
PTM	Phosphoprotein Ubl conjugation
Gene Ontology (GO)
Biological process	G2/M transition of mitotic cell cycle Inferred from sequence or structural similarity. Source: UniProtKB anti-apoptosis Inferred from sequence or structural similarity. Source: UniProtKB chromosome segregation Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Inferred from sequence or structural similarity. Source: UniProtKB establishment of chromosome localization Inferred from sequence or structural similarity. Source: UniProtKB mitosis Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of exit from mitosis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of mitotic cell cycle Inferred from sequence or structural similarity. Source: UniProtKB protein complex localization Inferred from sequence or structural similarity. Source: UniProtKB spindle checkpoint Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	centriole Inferred from sequence or structural similarity. Source: UniProtKB chromosome passenger complex Inferred from sequence or structural similarity. Source: UniProtKB chromosome, centromeric region Inferred from sequence or structural similarity. Source: UniProtKB cytoplasmic microtubule Inferred from sequence or structural similarity. Source: UniProtKB cytosol Inferred from sequence or structural similarity. Source: UniProtKB interphase microtubule organizing center Inferred from sequence or structural similarity. Source: UniProtKB midbody Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell spindle microtubule Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	cofactor binding Inferred from sequence or structural similarity. Source: UniProtKB cysteine-type endopeptidase inhibitor activity involved in apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB microtubule binding Inferred from sequence or structural similarity. Source: UniProtKB protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Baculoviral IAP repeat-containing protein 5		PRO_0000122359
Regions
	Repeat	18 – 88	71	BIR
Sites
	Metal binding	57	1	Zinc By similarity
	Metal binding	60	1	Zinc By similarity
	Metal binding	77	1	Zinc By similarity
	Metal binding	84	1	Zinc By similarity
Amino acid modifications
	Modified residue	34	1	Phosphothreonine; by CDK1 By similarity
	Modified residue	117	1	Phosphothreonine; by AURKB By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5RAH9 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 9E7CADCDF2822286	FASTA	142	16,389
	10 20 30 40 50 60 MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 70 80 90 100 110 120 FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 130 140 KKEFEETAKK VRRAIEQLAA MD

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR859036 mRNA. Translation: CAH91231.1.
RefSeq	NP_001125727.1. NM_001132255.1.
UniGene	Pab.6449.
3D structure databases
ProteinModelPortal	Q5RAH9.
SMR	Q5RAH9. Positions 5-142.
ModBase	Search...
Protein family/group databases
MEROPS	I32.005.
Proteomic databases
PRIDE	Q5RAH9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100172652.
KEGG	pon:100172652.
Organism-specific databases
CTD	332.
Phylogenomic databases
HOVERGEN	HBG050690.
InParanoid	Q5RAH9.
Family and domain databases
InterPro	IPR001370. BIR. [Graphical view]
Gene3D	G3DSA:1.10.1170.10. BIR. 1 hit.
KO	K08731.
Pfam	PF00653. BIR. 1 hit. [Graphical view]
SMART	SM00238. BIR. 1 hit. [Graphical view]
PROSITE	PS01282. BIR_REPEAT_1. False negative. PS50143. BIR_REPEAT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BIRC5_PONAB

Accession

Primary (citable) accession number: Q5RAH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program