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Protein

Copine-3

Gene

CPNE3

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-3Curated
Alternative name(s):
Copine IIIBy similarity
Gene namesi
Name:CPNE3By similarity
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448401 – 537Copine-3Add BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei197PhosphoserineBy similarity1
Modified residuei243PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine and threonine residues.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer. Interacts with ERBB2 (preferentially with the tyrosine phosphorylated form); this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner. Interacts with SHC1; this interaction may mediate the binding of CPNE3 with ERBB2. Interacts with RACK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000021004

Structurei

3D structure databases

ProteinModelPortaliQ5RAE1
SMRiQ5RAE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 99C2 1PROSITE-ProRule annotationAdd BLAST98
Domaini125 – 230C2 2PROSITE-ProRule annotationAdd BLAST106
Domaini291 – 513VWFAPROSITE-ProRule annotationAdd BLAST223

Sequence similaritiesi

Belongs to the copine family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
HOVERGENiHBG066841
InParanoidiQ5RAE1

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequencei

Sequence statusi: Complete.

Q5RAE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQCVTKVA LNVSCANLLD KDIGSKSDPL CVLFLNTSGQ QWYEVERTER
60 70 80 90 100
IKNCLNPQFS KTFIIDYYFE VVQKLKFGVY DIDNKTIELS DDDFLGECEC
110 120 130 140 150
TLGQVVSSKK LTRPLVMKNG RPAGKGSITI SAEEIKDNRV VLFEMEARKP
160 170 180 190 200
DNKDLFGKSD PYLEFHKQTS DGNWLMVHRT EVVKNNLNPV WRPFKISLNS
210 220 230 240 250
LCYGDMDKTI KVECYDYDND GSHDLIGTFQ TTMTKLKEAS RCSPVEFECI
260 270 280 290 300
NEKKRQKKKS YKNSGVISVK QCEITVECTF LDYIMGGCQL NFTVGVDFTG
310 320 330 340 350
SNDDPRSPDS LHYISPNGVN EYLTALWSVG LVIQDYDADK MFPAFGFGAQ
360 370 380 390 400
IPPQWQVSHE FPMNFNPSNP YCNGIQGIVE AYRSCLPQIK LYGPTNFSPI
410 420 430 440 450
INHVARFAAA AAQQQTASQY FVLLIITDGV ITDLDETRQA IVNASRLPMS
460 470 480 490 500
IIIVGVGGAD FSAMEFLDGD GGGLRSPSGE VAIRDIVQFV PFRQFQNAPK
510 520 530
EALAQCVLAE IPQQVVGYFN TYKLLPPKNP ATKQQKQ
Length:537
Mass (Da):60,102
Last modified:December 21, 2004 - v1
Checksum:i7EF0448F9B15D362
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859076 mRNA Translation: CAH91269.1
RefSeqiNP_001127397.1, NM_001133925.1

Genome annotation databases

GeneIDi100174464
KEGGipon:100174464

Similar proteinsi

Entry informationi

Entry nameiCPNE3_PONAB
AccessioniPrimary (citable) accession number: Q5RAE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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