Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Complement component C7

Gene

C7

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C7
Gene namesi
Name:C7
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane attack complex, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000004578223 – 843Complement component C7Add BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36C-linked (Man) tryptophanBy similarity1
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi91 ↔ 109By similarity
Disulfide bondi103 ↔ 119By similarity
Disulfide bondi128 ↔ 165By similarity
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi337 ↔ 353By similarity
Glycosylationi503C-linked (Man) tryptophanBy similarity1
Glycosylationi506C-linked (Man) tryptophanBy similarity1
Glycosylationi509C-linked (Man) tryptophanBy similarity1
Disulfide bondi571 ↔ 613By similarity
Disulfide bondi599 ↔ 626By similarity
Disulfide bondi631 ↔ 673By similarity
Disulfide bondi659 ↔ 688By similarity
Glycosylationi696O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi702 ↔ 713By similarity
Disulfide bondi715 ↔ 750By similarity
Disulfide bondi721 ↔ 743By similarity
Disulfide bondi728 ↔ 763By similarity
Glycosylationi754N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi773 ↔ 782By similarity
Disulfide bondi776 ↔ 789By similarity
Disulfide bondi791 ↔ 825By similarity
Disulfide bondi797 ↔ 818By similarity
Disulfide bondi805 ↔ 838By similarity

Post-translational modificationi

C7 has 28 disulfide bridges.By similarity
C-, N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ5RAD0

Interactioni

Subunit structurei

Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes (By similarity). Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000017232

Structurei

3D structure databases

ProteinModelPortaliQ5RAD0
SMRiQ5RAD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 80TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini83 – 121LDL-receptor class APROSITE-ProRule annotationAdd BLAST39
Domaini124 – 456MACPFPROSITE-ProRule annotationAdd BLAST333
Domaini457 – 487EGF-likeAdd BLAST31
Domaini500 – 549TSP type-1 2PROSITE-ProRule annotationAdd BLAST50
Domaini569 – 628Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini629 – 690Sushi 2PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni545 – 615CCP 1Add BLAST71
Regioni616 – 693CCP 2Add BLAST78
Regioni695 – 770Factor I module (FIM) 1Add BLAST76
Regioni771 – 843Factor I module (FIM) 2Add BLAST73

Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IDXP Eukaryota
ENOG410YJ70 LUCA
HOVERGENiHBG005367
InParanoidiQ5RAD0
KOiK03996

Family and domain databases

CDDicd00033 CCP, 2 hits
cd00112 LDLa, 1 hit
Gene3Di2.20.100.10, 2 hits
InterProiView protein in InterPro
IPR037564 Complement_C7
IPR003884 FacI_MAC
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001862 MAC_perforin
IPR020864 MACPF
IPR020863 MACPF_CS
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR19325:SF389 PTHR19325:SF389, 1 hit
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF01823 MACPF, 1 hit
PF00084 Sushi, 2 hits
PF00090 TSP_1, 2 hits
PRINTSiPR00764 COMPLEMENTC9
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00057 FIMAC, 2 hits
SM00192 LDLa, 1 hit
SM00457 MACPF, 1 hit
SM00209 TSP1, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
SSF82895 SSF82895, 2 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS00279 MACPF_1, 1 hit
PS51412 MACPF_2, 1 hit
PS50923 SUSHI, 2 hits
PS50092 TSP1, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RAD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVISLFILV GFIGESQIFS SASSPVNCQW DSYTPWSECN GCTKTQTRRR
60 70 80 90 100
SVAVYGQYGG QPCVGNAFET QSCEPTRGCP TEEGCGERFR CFSGQCISKS
110 120 130 140 150
LVCNGDSDCD EDSADEDRCE DSERRPSCDI DKPPPNIELT GNGYNELTGQ
160 170 180 190 200
FRNRVINTKS FGGQCRKVFS GDGKRFYRLS GNVLSYTFQV KINNDFNYEF
210 220 230 240 250
YNSTWSYVKH TSTEHTSSSR KRSFFRSSSS SSRSYTTHTN EIHKGKSYQL
260 270 280 290 300
LVVENTVEVT QFINNNPEFL QLAEPFWKEL SHLPSLYDYS AYRRLIDQYG
310 320 330 340 350
THYLQSGSLG GEYRVLFYVD SEKLKQNGFT SVEEKKCKSS GWHFVVKFSS
360 370 380 390 400
HGCKELENAL KAASGTQNNV LRGNPFIRGG GAGFISSLSY LELDNPAGNK
410 420 430 440 450
RRYSAWAKSV TDLPKVIKQK LTPLYELVKE VPCVSVKKLY LKRALEEYLD
460 470 480 490 500
EFDPCHCRPC QNGGLATVEG THCLCHCKPY TFGAACEQGV LVGNQAGGVD
510 520 530 540 550
GGWSCWSSWS SCVQGKKTRS RECNNPPPSG GGRSCIGETT ESTQCEDEEL
560 570 580 590 600
EHLRLLEPHC FPLSLVPTEF CPSPPALKDG FVQDEGTMFP VGKNVVYTCN
610 620 630 640 650
EGYSLIGNPV ARCGEDLQWL VGEMHCQKIA CVLPVLMDGI QSHPQKPFYT
660 670 680 690 700
VGEKVTVSCS GGMSLEGPSA FLCGSSLKWS PEMKNAHCVQ KENPLTQAVP
710 720 730 740 750
KCQRWEKLQN SRCVCKMPYE CVPSLDVCAR DERSKRILPL TVCKMHVLHC
760 770 780 790 800
QGRNYTLTGR DSCTLPASAE KACGACPLWG KCDAESSKCV CREASECEEE
810 820 830 840
GFSICVEVNG KEQTMSECEA GSLRCRGQSI SVTSIRPCAA ETQ
Length:843
Mass (Da):93,524
Last modified:December 21, 2004 - v1
Checksum:iE73CA154FAE97E62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859088 mRNA Translation: CAH91280.1
RefSeqiNP_001125756.1, NM_001132284.1

Genome annotation databases

GeneIDi100172681
KEGGipon:100172681

Similar proteinsi

Entry informationi

Entry nameiCO7_PONAB
AccessioniPrimary (citable) accession number: Q5RAD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health