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Protein

Complement component C7

Gene

C7

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C7
Gene namesi
Name:C7
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane attack complex, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 843821Complement component C7PRO_0000045782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361C-linked (Man)By similarity
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi91 ↔ 109By similarity
Disulfide bondi103 ↔ 119By similarity
Disulfide bondi128 ↔ 165By similarity
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi337 ↔ 353By similarity
Glycosylationi503 – 5031C-linked (Man)By similarity
Glycosylationi506 – 5061C-linked (Man)By similarity
Glycosylationi509 – 5091C-linked (Man)By similarity
Disulfide bondi571 ↔ 613By similarity
Disulfide bondi599 ↔ 626By similarity
Disulfide bondi631 ↔ 673By similarity
Disulfide bondi659 ↔ 688By similarity
Glycosylationi696 – 6961O-linked (GalNAc...)By similarity
Disulfide bondi702 ↔ 713By similarity
Disulfide bondi715 ↔ 750By similarity
Disulfide bondi721 ↔ 743By similarity
Disulfide bondi728 ↔ 763By similarity
Glycosylationi754 – 7541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi773 ↔ 782By similarity
Disulfide bondi776 ↔ 789By similarity
Disulfide bondi791 ↔ 825By similarity
Disulfide bondi797 ↔ 818By similarity
Disulfide bondi805 ↔ 838By similarity

Post-translational modificationi

C7 has 28 disulfide bridges.By similarity
C-, N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes (By similarity). Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000017232.

Structurei

3D structure databases

ProteinModelPortaliQ5RAD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 8054TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini83 – 12139LDL-receptor class APROSITE-ProRule annotationAdd
BLAST
Domaini124 – 456333MACPFPROSITE-ProRule annotationAdd
BLAST
Domaini457 – 48731EGF-likeAdd
BLAST
Domaini500 – 54950TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini569 – 62860Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini629 – 69062Sushi 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni545 – 61571CCP 1Add
BLAST
Regioni616 – 69378CCP 2Add
BLAST
Regioni695 – 77076Factor I module (FIM) 1Add
BLAST
Regioni771 – 84373Factor I module (FIM) 2Add
BLAST

Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated
Contains 1 EGF-like domain.Curated
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 1 MACPF domain.PROSITE-ProRule annotation
Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation
Contains 2 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
HOVERGENiHBG005367.
InParanoidiQ5RAD0.
KOiK03996.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR003884. FacI_MAC.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 2 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 2 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RAD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVISLFILV GFIGESQIFS SASSPVNCQW DSYTPWSECN GCTKTQTRRR
60 70 80 90 100
SVAVYGQYGG QPCVGNAFET QSCEPTRGCP TEEGCGERFR CFSGQCISKS
110 120 130 140 150
LVCNGDSDCD EDSADEDRCE DSERRPSCDI DKPPPNIELT GNGYNELTGQ
160 170 180 190 200
FRNRVINTKS FGGQCRKVFS GDGKRFYRLS GNVLSYTFQV KINNDFNYEF
210 220 230 240 250
YNSTWSYVKH TSTEHTSSSR KRSFFRSSSS SSRSYTTHTN EIHKGKSYQL
260 270 280 290 300
LVVENTVEVT QFINNNPEFL QLAEPFWKEL SHLPSLYDYS AYRRLIDQYG
310 320 330 340 350
THYLQSGSLG GEYRVLFYVD SEKLKQNGFT SVEEKKCKSS GWHFVVKFSS
360 370 380 390 400
HGCKELENAL KAASGTQNNV LRGNPFIRGG GAGFISSLSY LELDNPAGNK
410 420 430 440 450
RRYSAWAKSV TDLPKVIKQK LTPLYELVKE VPCVSVKKLY LKRALEEYLD
460 470 480 490 500
EFDPCHCRPC QNGGLATVEG THCLCHCKPY TFGAACEQGV LVGNQAGGVD
510 520 530 540 550
GGWSCWSSWS SCVQGKKTRS RECNNPPPSG GGRSCIGETT ESTQCEDEEL
560 570 580 590 600
EHLRLLEPHC FPLSLVPTEF CPSPPALKDG FVQDEGTMFP VGKNVVYTCN
610 620 630 640 650
EGYSLIGNPV ARCGEDLQWL VGEMHCQKIA CVLPVLMDGI QSHPQKPFYT
660 670 680 690 700
VGEKVTVSCS GGMSLEGPSA FLCGSSLKWS PEMKNAHCVQ KENPLTQAVP
710 720 730 740 750
KCQRWEKLQN SRCVCKMPYE CVPSLDVCAR DERSKRILPL TVCKMHVLHC
760 770 780 790 800
QGRNYTLTGR DSCTLPASAE KACGACPLWG KCDAESSKCV CREASECEEE
810 820 830 840
GFSICVEVNG KEQTMSECEA GSLRCRGQSI SVTSIRPCAA ETQ
Length:843
Mass (Da):93,524
Last modified:December 21, 2004 - v1
Checksum:iE73CA154FAE97E62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859088 mRNA. Translation: CAH91280.1.
RefSeqiNP_001125756.1. NM_001132284.1.

Genome annotation databases

GeneIDi100172681.
KEGGipon:100172681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859088 mRNA. Translation: CAH91280.1.
RefSeqiNP_001125756.1. NM_001132284.1.

3D structure databases

ProteinModelPortaliQ5RAD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000017232.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100172681.
KEGGipon:100172681.

Organism-specific databases

CTDi730.

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
HOVERGENiHBG005367.
InParanoidiQ5RAD0.
KOiK03996.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR003884. FacI_MAC.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 2 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 2 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCO7_PONAB
AccessioniPrimary (citable) accession number: Q5RAD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 21, 2004
Last modified: November 11, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.