Q5RA60 (INP4B_PONAB) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 39.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Type II inositol-3,4-bisphosphate 4-phosphatase EC=3.1.3.66 Alternative name(s): Inositol polyphosphate 4-phosphatase type II | ||
| Gene names |
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| Organism | Pongo abelii (Sumatran orangutan) | ||
| Taxonomic identifier | 9601 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Protein attributes
| Sequence length | 924 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate By similarity. |
| Catalytic activity | 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
| Enzyme regulation | Strongly inhibited by inositol hexakisphosphate By similarity. |
| Pathway | Signal transduction; phosphatidylinositol signaling pathway. |
| Sequence similarities | Belongs to the inositol-3,4-bisphosphate 4-phosphatase family. Contains 1 C2 domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Molecular function | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Inferred from electronic annotation. Source: EC phosphatidylinositol-4,5-bisphosphate 4-phosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q5RA60-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q5RA60-2) The sequence of this isoform differs from the canonical sequence as follows: 881-924: REGCRIENVL...PEGTYGKADT → SRQTQGALNE...SLALLLAKYQ |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 924 | 924 | Type II inositol-3,4-bisphosphate 4-phosphatase | PRO_0000190238 | |||||
Regions | |||||||||
| Domain | 25 – 149 | 125 | C2 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 487 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 881 – 924 | 44 | REGCR…GKADT → SRQTQGALNESDDPETGCLT DNKPTSRHFYPVALLLVSSH LLVVWLILSLALLLAKYQ in isoform 2. | VSP_015248 | |||||
Experimental info | |||||||||
| Sequence conflict | 137 | 1 | P → L in CAH90606. Ref.1 | ||||||
| Sequence conflict | 654 | 1 | R → Q in CAH90606. Ref.1 | ||||||
| Sequence conflict | 683 | 1 | A → V in CAH90606. Ref.1 | ||||||
| Sequence conflict | 719 | 1 | V → A in CAH90606. Ref.1 | ||||||
Sequences
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References
| [1] | The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain cortex. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR858378 mRNA. Translation: CAH90606.1. CR859161 mRNA. Translation: CAH91350.1. |
| RefSeq | NP_001127308.1. NM_001133836.1. |
| UniGene | Pab.2942. |
3D structure databases | |
| ProteinModelPortal | Q5RA60. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 100174369. |
| KEGG | pon:100174369. |
Organism-specific databases | |
| CTD | 8821. |
Phylogenomic databases | |
| HOVERGEN | HBG081796. |
| InParanoid | Q5RA60. |
Family and domain databases | |
| InterPro | IPR008973. C2_Ca/lipid-bd_dom_CaLB. [Graphical view] |
| KO | K01109. |
| SUPFAM | SSF49562. C2_CaLB. 1 hit. |
| PROSITE | PS50004. C2. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | INP4B_PONAB | ||||||||
| Accession | Primary (citable) accession number: Q5RA60 Secondary accession number(s): Q5RCA1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |