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Protein

Type II inositol 3,4-bisphosphate 4-phosphatase

Gene

INPP4B

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.By similarity

Catalytic activityi

1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

Enzyme regulationi

Strongly inhibited by inositol hexakisphosphate.By similarity

Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00944.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II inositol 3,4-bisphosphate 4-phosphatase (EC:3.1.3.66)
Alternative name(s):
Inositol polyphosphate 4-phosphatase type II
Gene namesi
Name:INPP4B
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 924924Type II inositol 3,4-bisphosphate 4-phosphatasePRO_0000190238Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000016852.

Structurei

3D structure databases

ProteinModelPortaliQ5RA60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 149125C2Add
BLAST

Sequence similaritiesi

Contains 1 C2 domain.Curated

Phylogenomic databases

eggNOGiKOG4428. Eukaryota.
ENOG410YV83. LUCA.
HOVERGENiHBG081796.
InParanoidiQ5RA60.
KOiK01109.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5RA60-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIKEEGASE EGQHFLPTAQ ASDPGDCQFT SIQKTPNEPQ LEFILACKDL
60 70 80 90 100
VAPVRDRKLN TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS
110 120 130 140 150
EYPIYEETKI KLTVYDVKDK SHDTVRTSVL PEHKDSPPEI GRSFLGYASF
160 170 180 190 200
KVGELLKSKE QLLVLSLRTS DGGKVVGTIE VSVVKMGEIE DGEADHITTD
210 220 230 240 250
IQGQKCALVC ECTAPESVSG KDNLPFLNSV LKNPVCKLYR FPTSDNKWMR
260 270 280 290 300
IREQMSESIL SFHIPKELIS LHIKEDLCRN QEIKELGELS PHWDNLRKNV
310 320 330 340 350
LTHCDQMVNM YQDILTELSK ETGSSFKSSS SKGDKTLEFV PINLHLQRMQ
360 370 380 390 400
VHSPHLKDAL YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI
410 420 430 440 450
YYSPENTAKA KEVLSNINQL QPLIATHADL LLNSASQHSP DSLKNSLKML
460 470 480 490 500
SEKTELFVHA FKDQLVRSAL LALYTARPGG ILKKPPSPKS STEESSPQDQ
510 520 530 540 550
PPLMRGQDSI PHHSDYDEEE WDRVWANVGK SLNCIIAMVD KLIERDGGSE
560 570 580 590 600
GSGGNNDGEK EPSLADAIPS HPREDWYEQL YPLILTLKDC MGEVVNRAKQ
610 620 630 640 650
SLTFVLLQEL AYSLPQCLML TLRRDVVFSQ ALAGLVCGFI IKLQTSLYDP
660 670 680 690 700
GFLRQLHTVG LIVQYEGLLS TYSDEIGMLE DMAVGISDLK KVAFKIIEAK
710 720 730 740 750
SNDVLPVITG RREHYVVEVK LPARMFESLP LQIKEGQLLH VYPVLFNVGI
760 770 780 790 800
NEQQTLAERF GDVSLQESIN QENFELLQEY YKIFMEKMPP DYISHFQEQN
810 820 830 840 850
DLKALLENLL QNIQSKKRKN VEIMWLAATI CRKLNGIRFT CCKSAKDRTS
860 870 880 890 900
MSVTLEQCSI LRDEHQLHKD FFIRALDCMR REGCRIENVL KNIKCRKYAF
910 920
NMLQLMAFPK YYRPPEGTYG KADT
Length:924
Mass (Da):104,713
Last modified:December 21, 2004 - v1
Checksum:i1463135AEAD9523E
GO
Isoform 2 (identifier: Q5RA60-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     881-924: REGCRIENVL...PEGTYGKADT → SRQTQGALNE...SLALLLAKYQ

Show »
Length:938
Mass (Da):105,935
Checksum:i1C323DFF6F73AE1F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371P → L in CAH90606 (Ref. 1) Curated
Sequence conflicti654 – 6541R → Q in CAH90606 (Ref. 1) Curated
Sequence conflicti683 – 6831A → V in CAH90606 (Ref. 1) Curated
Sequence conflicti719 – 7191V → A in CAH90606 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei881 – 92444REGCR…GKADT → SRQTQGALNESDDPETGCLT DNKPTSRHFYPVALLLVSSH LLVVWLILSLALLLAKYQ in isoform 2. 1 PublicationVSP_015248Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858378 mRNA. Translation: CAH90606.1.
CR859161 mRNA. Translation: CAH91350.1.
RefSeqiNP_001127308.1. NM_001133836.1.
UniGeneiPab.2942.

Genome annotation databases

GeneIDi100174369.
KEGGipon:100174369.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR858378 mRNA. Translation: CAH90606.1.
CR859161 mRNA. Translation: CAH91350.1.
RefSeqiNP_001127308.1. NM_001133836.1.
UniGeneiPab.2942.

3D structure databases

ProteinModelPortaliQ5RA60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000016852.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100174369.
KEGGipon:100174369.

Organism-specific databases

CTDi8821.

Phylogenomic databases

eggNOGiKOG4428. Eukaryota.
ENOG410YV83. LUCA.
HOVERGENiHBG081796.
InParanoidiQ5RA60.
KOiK01109.

Enzyme and pathway databases

UniPathwayiUPA00944.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINP4B_PONAB
AccessioniPrimary (citable) accession number: Q5RA60
Secondary accession number(s): Q5RCA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: November 11, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.