Reviewed,
UniProtKB/Swiss-Prot Q5RA60 (INP4B_PONAB)
Last modified
March 3, 2009.
Version 25.
History...
Clusters with 100%,
90%,
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Type II inositol-3,4-bisphosphate 4-phosphatase EC=3.1.3.66 Alternative name(s): Inositol polyphosphate 4-phosphatase type II | ||
| Gene names |
| ||
| Organism | Pongo abelii (Sumatran orangutan) | ||
| Taxonomic identifier | 9601 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Protein attributes
| Sequence length | 924 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate By similarity. |
| Catalytic activity | 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
| Enzyme regulation | Strongly inhibited by inositol hexakisphosphate By similarity. |
| Pathway | Signal transduction; phosphatidylinositol signaling pathway. |
| Sequence similarities | Belongs to the inositol-3,4-bisphosphate 4-phosphatase family. Contains 1 C2 domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Molecular function | phosphatidyl-inositol-4,5-bisphosphate 4-phosphatase activity Inferred from electronic annotation. Source: EC phosphatidylinositol-3,4-bisphosphate 4-phosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q5RA60-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q5RA60-2) The sequence of this isoform differs from the canonical sequence as follows: 881-924: REGCRIENVL...PEGTYGKADT → SRQTQGALNE...SLALLLAKYQ |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 924 | 924 | Type II inositol-3,4-bisphosphate 4-phosphatase | PRO_0000190238 | |||||
Regions | |||||||||
| Domain | 25 – 149 | 125 | C2 | ||||||
Natural variations | |||||||||
| Alternative sequence | 881 – 924 | 44 | REGCR…GKADT → SRQTQGALNESDDPETGCLT DNKPTSRHFYPVALLLVSSH LLVVWLILSLALLLAKYQ in isoform 2. | VSP_015248 | |||||
Experimental info | |||||||||
| Sequence conflict | 137 | 1 | P → L in CAH90606. Ref.1 | ||||||
| Sequence conflict | 654 | 1 | R → Q in CAH90606. Ref.1 | ||||||
| Sequence conflict | 683 | 1 | A → V in CAH90606. Ref.1 | ||||||
| Sequence conflict | 719 | 1 | V → A in CAH90606. Ref.1 | ||||||
Sequences
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References
| [1] | The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain cortex. |
Cross-references
Sequence databases | |
|---|---|
| CR858378 mRNA. Translation: CAH90606.1. CR859161 mRNA. Translation: CAH91350.1. | |
| RefSeq | NP_001127308.1. |
| UniGene | Pab.2942 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 100174369. |
Phylogenomic databases | |
| HOVERGEN | Q5RA60. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.66. 269192. |
Family and domain databases | |
| PROSITE | PS50004. C2. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | INP4B_PONAB | ||||||||
| Accession | Primary (citable) accession number: Q5RA60 Secondary accession number(s): Q5RCA1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
