Reviewed, UniProtKB/Swiss-Prot Q5RA57 (PLCC_PONAB)

Names and origin

Protein names

Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
    EC=2.3.1.51
Alternative name(s):
    1-acylglycerol-3-phosphate O-acyltransferase 3
      Short name=1-AGP acyltransferase 3
      Short name=1-AGPAT 3
    Lysophosphatidic acid acyltransferase gamma
      Short name=LPAAT-gamma

Gene names

Name:

AGPAT3

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone By similarity.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma		PRO_0000208196
Regions
	Transmembrane	11 – 31	21	Potential
	Transmembrane	124 – 144	21	Potential
	Transmembrane	308 – 330	23	Potential
	Transmembrane	335 – 357	23	Potential
	Motif	96 – 101	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	Q5RA57-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 847A5A1442081A79	FASTA	376	43,365
	10 20 30 40 50 60 MGLLAFLKTQ FVLHPLVGFV FVVSGLVINF VQLCTLALWP VSKQLYRRLN CRLAYSLWSQ 70 80 90 100 110 120 LVMLLEWWSC TECTLFTDQA TVERFGKEHA VIILNHNFEI DFLCGWTMCE RFGVLGSSKV 130 140 150 160 170 180 LAKKELLYVP LIGWTWYFLE IVFCKRKWEE DRDTVVEGLR RLSDYPEYMW FLLYCEGTRF 190 200 210 220 230 240 TETKHRVSME VAAAKGLPVL KYHLLPRTKG FTTAVKCLRG TVAAVYDVTL NFRGNKNPSL 250 260 270 280 290 300 LGILYGKKYE ADMCVRRFPL EDIPLDEKEA AQWLHKLYQE KDALQEIYNQ KGMFPGEQFK 310 320 330 340 350 360 PARRPWTLLN FLSWATILLS PLFSFVLGVF ASGSPLLILT FLGFVGAASF GVRRLIGVTE 370 IEKGSSYGNQ EFKKKE

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR859164 mRNA. Translation: CAH91353.1.
RefSeq	NP_001127407.1.
UniGene	Pab.8061
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100174477.
Organism-specific databases
CTD	100174477.
Phylogenomic databases
HOVERGEN	Q5RA57.
Enzyme and pathway databases
BRENDA	2.3.1.51. 269192.
Family and domain databases
InterPro	IPR002123. Acyltransferase. [Graphical view]
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLCC_PONAB

Accession

Primary (citable) accession number: Q5RA57

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	December 21, 2004
Last modified:	October 13, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)