Reviewed, UniProtKB/Swiss-Prot Q5RA52 (PDP1_PONAB)

Names and origin

Protein names

Recommended name:
    [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
      Short name=PDP 1
    EC=3.1.3.43
Alternative name(s):
    Pyruvate dehydrogenase phosphatase, catalytic subunit 1
      Short name=PDPC 1
    Protein phosphatase 2C

Gene names

Name:	PDP1
Synonyms:	PPM2C

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	537 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex By similarity.
Catalytic activity	[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subunit structure	Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the PP2C family.
Sequence caution	The sequence CAH93445.1 differs from that shown. Reason: Erroneous termination at position 45. Translated as Arg.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Calcium Magnesium Metal-binding
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell protein serine/threonine phosphatase complex Inferred from electronic annotation. Source: InterPro
Molecular function	[pyruvate dehydrogenase (lipoamide)] phosphatase activity Inferred from electronic annotation. Source: EC calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 71	71	Mitochondrion By similarity
	Chain	72 – 537	466	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial		PRO_0000341945
Sites
	Metal binding	144	1	Magnesium 1 By similarity
	Metal binding	144	1	Magnesium 2 By similarity
	Metal binding	145	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	418	1	Magnesium 2 By similarity
Experimental info
	Sequence conflict	250	1	E → G in CAH93445. Ref.1
	Sequence conflict	502	1	K → E in CAH91692. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q5RA52-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 07AE822466FE4DF0	FASTA	537	61,077
	10 20 30 40 50 60 MPAPTQLFFP LIRNCELSRI YGTACYCHHK HLCCSSSYIP QSRLRYTPHP AYATFCRPKE 70 80 90 100 110 120 NWWHYTQGRR YASTPQKFYL TPPQVNSILK ANEYSFKVPE FDGKNVSSIL GFDSNQLPAN 130 140 150 160 170 180 APIEDRRSAA TCLQTRGMLL GVFDGHAGCA CSQAVSERLF YYIAVSLLPH ETLLEIENAV 190 200 210 220 230 240 ESGRALLPIL QWHKHPNDYF SKEASKLYFN SLRTYWQELI DLNTGESTDI DVKEALINAF 250 260 270 280 290 300 KRLDNDISLE AQVGDPNSFL NYLVLRVAFS GATACVAHVD GVDLHVANTG DSRAMLGVQE 310 320 330 340 350 360 EDGSWSALTL SNDHNAQNER ELERLKLEHP KSEAKSVVKQ DRLLGLLMPF RAFGDVKFKW 370 380 390 400 410 420 SIDLQKRVIE SGPDQLNDNE YTKFIPPNYH TPPYLTAEPE VTYHRLRPQD KFLVLATDGL 430 440 450 460 470 480 WETMHRQDVV RIVGEYLTGM HHQQPIAVGG YKVTLGQMHG LLTERRTKMS SVFEDQNAAT 490 500 510 520 530 HLIRHAVGNN EFGTVDHERL SKMLSLPEEL ARMYRDDITI IVVQFNSHVV GAYQNQE

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR859169 mRNA. Translation: CAH91358.1. CR859524 mRNA. Translation: CAH91692.1. CR861198 mRNA. Translation: CAH93269.1. Different initiation. CR861387 mRNA. Translation: CAH93445.1. Sequence problems.
RefSeq	NP_001127016.1. NP_001128828.1.
UniGene	Pab.18466 Pab.860
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100174041. 100189742.
Phylogenomic databases
HOVERGEN	Q5RA52.
Family and domain databases
InterPro	IPR015655. PP2C. IPR001932. PP2C-related. IPR000222. PP2C_Mn2_Asp60_BS. IPR014045. PP2C_N. [Graphical view]
Gene3D	G3DSA:3.60.40.10. PP2C-related. 1 hit.
PANTHER	PTHR13832. PP2C. 1 hit.
Pfam	PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
PROSITE	PS01032. PP2C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDP1_PONAB

Accession

Primary (citable) accession number: Q5RA52
Secondary accession number(s): Q5R471, Q5R4P7, Q5R968

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	December 21, 2004
Last modified:	March 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)