true2006-10-032024-01-2466RPAP2_PONABThe German cDNA consortium2004-11EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]KidneyEukaryotaRtr1/RPAP2Rtr1/RPAP2_domRtr1/RPAP2_sfRNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATEDUNCHARACTERIZEDRPAP2_Rtr1ZF_RTR1Putative RNA polymerase II subunit B1 CTD phosphatase RPAP23.1.3.16RNA polymerase II-associated protein 2RPAP2Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity).Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD (By similarity).Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner.Belongs to the RPAP2 family.Removed1Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2694032612RTR1-type77160Disordered40Disordered193267Disordered2923173368Polar residues201243Polar residues310100105136140N-acetylalaninePhosphoserine9Phosphoserine216Phosphoserine433Phosphoserine4802004-12-21169534c39813648bf8a5224f483b0dd60a679eMADCAGPSSAGRKAGAPRRSRKAAGTKQTSTLKQEDASKRKAELEAAVRKKIEFERKALHIVEQLLEENITEEFLMECGKFITPAHYSDVVDERSIVKLCGYPLCQKKLGIVPKQKYKISTKTNKVYDITERKSFCSNFCYQASKFFEAQIPKTPVWVREEERHPDFQLLKEQQSGHSGEEVQLCSKAIKTSDIDNPSHFEKQYESSSSSTHSDSSSDNEQDFVSSILPGNRPNSTSIRPQLHQKSIMKKKAGHKANSKHKDKEQTVIDVTEQLGDCKLDSQEKDATCELPLQKVNTQSSSNSTLPERLKASENSESEYSRSEITLVGISKKSAEHFKRKFAKSNQVSRSVSSSVQVCPEVGKRNLLKILKETLIEWKTEETLRFLYGQNYASVCLKPEASLVKEELDEDDIISDPDSHFPAWRESQNSLDESLPFRGSGTAIKPLPSYENLKKETEKLNLRIREFYRGRYVLDEETTKSQDSEEHDSTFPLIDSSSQNQIRKRIVLEKLSKVLPGLLVPLQITLGDIYTQLKNLVRTFRLTNRNIIHKPAEWTLIAMVLLSLLTPILGIQKHSQEGMVFTRFLDTLLEELHLKNEDLESLTIVFRTSCLPEtruetruetruetruetruetruetrue