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Q5RA37 (RPAP2_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

EC=3.1.3.16
Alternative name(s):
RNA polymerase II-associated protein 2
Gene names
Name:RPAP2
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length612 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner By similarity.

Sequence similarities

Belongs to the RPAP2 family.

Contains 1 RTR1-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 612611Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
PRO_0000250650

Regions

Zinc finger77 – 16084RTR1-type
Coiled coil33 – 6836 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue4331Phosphoserine By similarity
Modified residue4801Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5RA37 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 791442A755D1461E

FASTA61269,534
        10         20         30         40         50         60 
MADCAGPSSA GRKAGAPRRS RKAAGTKQTS TLKQEDASKR KAELEAAVRK KIEFERKALH 

        70         80         90        100        110        120 
IVEQLLEENI TEEFLMECGK FITPAHYSDV VDERSIVKLC GYPLCQKKLG IVPKQKYKIS 

       130        140        150        160        170        180 
TKTNKVYDIT ERKSFCSNFC YQASKFFEAQ IPKTPVWVRE EERHPDFQLL KEQQSGHSGE 

       190        200        210        220        230        240 
EVQLCSKAIK TSDIDNPSHF EKQYESSSSS THSDSSSDNE QDFVSSILPG NRPNSTSIRP 

       250        260        270        280        290        300 
QLHQKSIMKK KAGHKANSKH KDKEQTVIDV TEQLGDCKLD SQEKDATCEL PLQKVNTQSS 

       310        320        330        340        350        360 
SNSTLPERLK ASENSESEYS RSEITLVGIS KKSAEHFKRK FAKSNQVSRS VSSSVQVCPE 

       370        380        390        400        410        420 
VGKRNLLKIL KETLIEWKTE ETLRFLYGQN YASVCLKPEA SLVKEELDED DIISDPDSHF 

       430        440        450        460        470        480 
PAWRESQNSL DESLPFRGSG TAIKPLPSYE NLKKETEKLN LRIREFYRGR YVLDEETTKS 

       490        500        510        520        530        540 
QDSEEHDSTF PLIDSSSQNQ IRKRIVLEKL SKVLPGLLVP LQITLGDIYT QLKNLVRTFR 

       550        560        570        580        590        600 
LTNRNIIHKP AEWTLIAMVL LSLLTPILGI QKHSQEGMVF TRFLDTLLEE LHLKNEDLES 

       610 
LTIVFRTSCL PE 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR859185 mRNA. Translation: CAH91373.1.
RefSeqNP_001125811.1. NM_001132339.1.
UniGenePab.7496.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5RA37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100172739.
KEGGpon:100172739.

Organism-specific databases

CTD79871.

Phylogenomic databases

HOVERGENHBG080953.
InParanoidQ5RA37.

Family and domain databases

InterProIPR007308. DUF408.
[Graphical view]
PfamPF04181. RPAP2_Rtr1. 1 hit.
[Graphical view]
PROSITEPS51479. ZF_RTR1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPAP2_PONAB
AccessionPrimary (citable) accession number: Q5RA37
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families