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Q5RA36

- CCL2_PONAB

UniProt

Q5RA36 - CCL2_PONAB

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Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Binds to CCR2 and CCR4 (By similarity).By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Small-inducible cytokine A2
Gene namesi
Name:CCL2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 2PRO_0000005150Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5RA36.
SMRiQ5RA36. Positions 24-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG017871.
InParanoidiQ5RA36.
KOiK14624.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR008097. Chemokine_CX3CL1.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01721. FRACTALKINE.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5RA36-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSAALLCL LLIAATFSPQ GLAQPDAINA PVTCCYNFTN RKISVQRLAS
60 70 80 90
YRRITSSKCP KEAVIFKTIV AKEICADPKQ KWVQDSMDHL DKQTQTLKT
Length:99
Mass (Da):11,015
Last modified:December 21, 2004 - v1
Checksum:i45FCA8CC64FF8A4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859186 mRNA. Translation: CAH91374.1.
RefSeqiNP_001125812.1. NM_001132340.2.
UniGeneiPab.7458.

Genome annotation databases

GeneIDi100172740.
KEGGipon:100172740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859186 mRNA. Translation: CAH91374.1 .
RefSeqi NP_001125812.1. NM_001132340.2.
UniGenei Pab.7458.

3D structure databases

ProteinModelPortali Q5RA36.
SMRi Q5RA36. Positions 24-94.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100172740.
KEGGi pon:100172740.

Organism-specific databases

CTDi 6347.

Phylogenomic databases

HOVERGENi HBG017871.
InParanoidi Q5RA36.
KOi K14624.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR008097. Chemokine_CX3CL1.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR01721. FRACTALKINE.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCCL2_PONAB
AccessioniPrimary (citable) accession number: Q5RA36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 21, 2004
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3