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Q5RA36

- CCL2_PONAB

UniProt

Q5RA36 - CCL2_PONAB

Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Binds to CCR2 and CCR4 By similarity.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 2
    Alternative name(s):
    Small-inducible cytokine A2
    Gene namesi
    Name:CCL2
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9976C-C motif chemokine 2PRO_0000005150Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi34 ↔ 59By similarity
    Disulfide bondi35 ↔ 75By similarity
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Interactioni

    Subunit structurei

    Monomer or homodimer; in equilibrium.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5RA36.
    SMRiQ5RA36. Positions 24-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG017871.
    InParanoidiQ5RA36.
    KOiK14624.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR008097. Chemokine_CX3CL1.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR01721. FRACTALKINE.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5RA36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAALLCL LLIAATFSPQ GLAQPDAINA PVTCCYNFTN RKISVQRLAS   50
    YRRITSSKCP KEAVIFKTIV AKEICADPKQ KWVQDSMDHL DKQTQTLKT 99
    Length:99
    Mass (Da):11,015
    Last modified:December 21, 2004 - v1
    Checksum:i45FCA8CC64FF8A4F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859186 mRNA. Translation: CAH91374.1.
    RefSeqiNP_001125812.1. NM_001132340.2.
    UniGeneiPab.7458.

    Genome annotation databases

    GeneIDi100172740.
    KEGGipon:100172740.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859186 mRNA. Translation: CAH91374.1 .
    RefSeqi NP_001125812.1. NM_001132340.2.
    UniGenei Pab.7458.

    3D structure databases

    ProteinModelPortali Q5RA36.
    SMRi Q5RA36. Positions 24-94.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100172740.
    KEGGi pon:100172740.

    Organism-specific databases

    CTDi 6347.

    Phylogenomic databases

    HOVERGENi HBG017871.
    InParanoidi Q5RA36.
    KOi K14624.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR008097. Chemokine_CX3CL1.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR01721. FRACTALKINE.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiCCL2_PONAB
    AccessioniPrimary (citable) accession number: Q5RA36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3