Reviewed, UniProtKB/Swiss-Prot Q5R9Z1 (VPS29_PONAB)

Names and origin

Protein names

Recommended name:
    Vacuolar protein sorting-associated protein 29
    EC=3.1.3.3
Alternative name(s):
    Vesicle protein sorting 29

Gene names

Name:

VPS29

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) By similarity.
Catalytic activity	O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN By similarity. Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2 By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Endosome membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the VPS29 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Endosome Membrane
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
PTM	Acetylation
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endosome Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoserine phosphatase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Vacuolar protein sorting-associated protein 29		PRO_0000339649
Amino acid modifications
	Modified residue	50	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R9Z1-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: CCCDDE6B720C864E	FASTA	182	20,466
	10 20 30 40 50 60 MLVLVLGDLH IPHRCNSLPA KFKKLLVPGK IQHILCTGNL CTKESYDYLK TLAGDVHIVR 70 80 90 100 110 120 GDFDENLNYP EQKVVTVGQF KIGLIHGHQV IPWGDMASLA LLQRQFDVDI LISGHTHKFE 130 140 150 160 170 180 AFEHENKFYI NPGSATGAYN ALEANIIPSF VLMDIQASTV VTYVYQLIGD DVKVERIEYK KS

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR859239 mRNA. Translation: CAH91419.1.
RefSeq	NP_001129021.1.
3D structure databases
SMR	Q5R9Z1. Positions 1-182.
ModBase	Search...
Genome annotation databases
GeneID	100190862.
Organism-specific databases
CTD	100190862.
Phylogenomic databases
HOVERGEN	Q5R9Z1.
Family and domain databases
InterPro	IPR004843. M-pesterase. IPR000979. UPF0025. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
TIGRFAMs	TIGR00040. yfcE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VPS29_PONAB

Accession

Primary (citable) accession number: Q5R9Z1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	December 21, 2004
Last modified:	October 13, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)