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Q5R9Y1

- FSTL1_PONAB

UniProt

Q5R9Y1 - FSTL1_PONAB

Protein

Follistatin-related protein 1

Gene

FSTL1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: UniProtKB-KW

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Follistatin-related protein 1
    Alternative name(s):
    Follistatin-like protein 1
    Gene namesi
    Name:FSTL1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 3

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 306288Follistatin-related protein 1PRO_0000329283Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi52 ↔ 82PROSITE-ProRule annotation
    Disulfide bondi56 ↔ 75PROSITE-ProRule annotation
    Disulfide bondi64 ↔ 96PROSITE-ProRule annotation
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ5R9Y1.

    Interactioni

    Subunit structurei

    Interacts with SCN10A.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R9Y1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 5124Follistatin-likeAdd
    BLAST
    Domaini46 – 9853Kazal-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini142 – 17635EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini191 – 22636EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini231 – 28555VWFCAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 follistatin-like domain.Curated
    Contains 1 Kazal-like domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    GeneTreeiENSGT00530000063333.
    HOGENOMiHOG000007780.
    HOVERGENiHBG051665.
    InParanoidiQ5R9Y1.
    OMAiRGLCIDA.
    OrthoDBiEOG7WT427.
    TreeFamiTF106409.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view]
    PfamiPF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R9Y1-1 [UniParc]FASTAAdd to Basket

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    MWKRWLALAL VAVAWVRAEE ELRSKSKICA NVFCGAGREC AVTEKGEPTC    50
    LCIEQCKPHK RPVCGSNGKT YLNHCELHRD ACLTGSKIQV DYDGHCKEKK 100
    SVSPSASPVV CYQSNRDELR RRIIQWLEAE IIPDGWFSRG SNYSEILDKY 150
    FKNFDNGDSR LDSSEFLKFV EQNETAINIT TYPDQENNKL LRGLCVDALI 200
    ELSDENADWK LSFQEFLKCL NPSFNPPEKK CALEDETYAD GAETEVDCNR 250
    CVCACGNWVC TAMTCDGKNQ KGAQTQTEEE MTRYVQELQK HQETAEKTKR 300
    VSTKEI 306
    Length:306
    Mass (Da):34,829
    Last modified:April 8, 2008 - v2
    Checksum:i838A0DC9BEC99D9B
    GO

    Sequence cautioni

    The sequence CAH91429.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859249 mRNA. Translation: CAH91429.1. Different initiation.
    RefSeqiNP_001125838.1. NM_001132366.1.

    Genome annotation databases

    EnsembliENSPPYT00000015705; ENSPPYP00000015102; ENSPPYG00000013504.
    GeneIDi100172767.
    KEGGipon:100172767.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859249 mRNA. Translation: CAH91429.1 . Different initiation.
    RefSeqi NP_001125838.1. NM_001132366.1.

    3D structure databases

    ProteinModelPortali Q5R9Y1.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5R9Y1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000015705 ; ENSPPYP00000015102 ; ENSPPYG00000013504 .
    GeneIDi 100172767.
    KEGGi pon:100172767.

    Organism-specific databases

    CTDi 11167.

    Phylogenomic databases

    GeneTreei ENSGT00530000063333.
    HOGENOMi HOG000007780.
    HOVERGENi HBG051665.
    InParanoidi Q5R9Y1.
    OMAi RGLCIDA.
    OrthoDBi EOG7WT427.
    TreeFami TF106409.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view ]
    Pfami PF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiFSTL1_PONAB
    AccessioniPrimary (citable) accession number: Q5R9Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3