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Q5R9Y1

- FSTL1_PONAB

UniProt

Q5R9Y1 - FSTL1_PONAB

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Protein

Follistatin-related protein 1

Gene

FSTL1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. response to starvation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI01.967.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 1
Alternative name(s):
Follistatin-like protein 1
Gene namesi
Name:FSTL1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 3

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 306288Follistatin-related protein 1PRO_0000329283Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 82PROSITE-ProRule annotation
Disulfide bondi56 ↔ 75PROSITE-ProRule annotation
Disulfide bondi64 ↔ 96PROSITE-ProRule annotation
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ5R9Y1.

Interactioni

Subunit structurei

Interacts with SCN10A.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5R9Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 5124Follistatin-likeAdd
BLAST
Domaini46 – 9853Kazal-likePROSITE-ProRule annotationAdd
BLAST
Domaini142 – 17635EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini191 – 22636EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini231 – 28555VWFCAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 follistatin-like domain.Curated
Contains 1 Kazal-like domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00530000063333.
HOGENOMiHOG000007780.
HOVERGENiHBG051665.
InParanoidiQ5R9Y1.
OMAiRGLCIDA.
OrthoDBiEOG7WT427.
TreeFamiTF106409.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R9Y1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWKRWLALAL VAVAWVRAEE ELRSKSKICA NVFCGAGREC AVTEKGEPTC
60 70 80 90 100
LCIEQCKPHK RPVCGSNGKT YLNHCELHRD ACLTGSKIQV DYDGHCKEKK
110 120 130 140 150
SVSPSASPVV CYQSNRDELR RRIIQWLEAE IIPDGWFSRG SNYSEILDKY
160 170 180 190 200
FKNFDNGDSR LDSSEFLKFV EQNETAINIT TYPDQENNKL LRGLCVDALI
210 220 230 240 250
ELSDENADWK LSFQEFLKCL NPSFNPPEKK CALEDETYAD GAETEVDCNR
260 270 280 290 300
CVCACGNWVC TAMTCDGKNQ KGAQTQTEEE MTRYVQELQK HQETAEKTKR

VSTKEI
Length:306
Mass (Da):34,829
Last modified:April 8, 2008 - v2
Checksum:i838A0DC9BEC99D9B
GO

Sequence cautioni

The sequence CAH91429.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859249 mRNA. Translation: CAH91429.1. Different initiation.
RefSeqiNP_001125838.1. NM_001132366.1.

Genome annotation databases

EnsembliENSPPYT00000015705; ENSPPYP00000015102; ENSPPYG00000013504.
GeneIDi100172767.
KEGGipon:100172767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859249 mRNA. Translation: CAH91429.1 . Different initiation.
RefSeqi NP_001125838.1. NM_001132366.1.

3D structure databases

ProteinModelPortali Q5R9Y1.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I01.967.

Proteomic databases

PRIDEi Q5R9Y1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000015705 ; ENSPPYP00000015102 ; ENSPPYG00000013504 .
GeneIDi 100172767.
KEGGi pon:100172767.

Organism-specific databases

CTDi 11167.

Phylogenomic databases

GeneTreei ENSGT00530000063333.
HOGENOMi HOG000007780.
HOVERGENi HBG051665.
InParanoidi Q5R9Y1.
OMAi RGLCIDA.
OrthoDBi EOG7WT427.
TreeFami TF106409.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view ]
Pfami PF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiFSTL1_PONAB
AccessioniPrimary (citable) accession number: Q5R9Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3