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Q5R9Y1 (FSTL1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Follistatin-related protein 1
Alternative name(s):
Follistatin-like protein 1
Gene names
Name:FSTL1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin By similarity.

Subunit structure

Interacts with SCN10A By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Contains 2 EF-hand domains.

Contains 1 follistatin-like domain.

Contains 1 Kazal-like domain.

Contains 1 VWFC domain.

Sequence caution

The sequence CAH91429.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandHeparin-binding
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 306288Follistatin-related protein 1
PRO_0000329283

Regions

Domain28 – 5124Follistatin-like
Domain46 – 9853Kazal-like
Domain142 – 17635EF-hand 1
Domain191 – 22636EF-hand 2
Domain231 – 28555VWFC

Amino acid modifications

Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Disulfide bond52 ↔ 82 By similarity
Disulfide bond56 ↔ 75 By similarity
Disulfide bond64 ↔ 96 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R9Y1 [UniParc].

Last modified April 8, 2008. Version 2.
Checksum: 838A0DC9BEC99D9B

FASTA30634,829
        10         20         30         40         50         60 
MWKRWLALAL VAVAWVRAEE ELRSKSKICA NVFCGAGREC AVTEKGEPTC LCIEQCKPHK 

        70         80         90        100        110        120 
RPVCGSNGKT YLNHCELHRD ACLTGSKIQV DYDGHCKEKK SVSPSASPVV CYQSNRDELR 

       130        140        150        160        170        180 
RRIIQWLEAE IIPDGWFSRG SNYSEILDKY FKNFDNGDSR LDSSEFLKFV EQNETAINIT 

       190        200        210        220        230        240 
TYPDQENNKL LRGLCVDALI ELSDENADWK LSFQEFLKCL NPSFNPPEKK CALEDETYAD 

       250        260        270        280        290        300 
GAETEVDCNR CVCACGNWVC TAMTCDGKNQ KGAQTQTEEE MTRYVQELQK HQETAEKTKR 


VSTKEI 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR859249 mRNA. Translation: CAH91429.1. Different initiation.
RefSeqNP_001125838.1. NM_001132366.1.

3D structure databases

ProteinModelPortalQ5R9Y1.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5R9Y1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000015705; ENSPPYP00000015102; ENSPPYG00000013504.
GeneID100172767.
KEGGpon:100172767.

Organism-specific databases

CTD11167.

Phylogenomic databases

GeneTreeENSGT00530000063333.
HOGENOMHOG000007780.
HOVERGENHBG051665.
InParanoidQ5R9Y1.
OMAWVHAEEE.
OrthoDBEOG7WT427.
TreeFamTF106409.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view]
PfamPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFSTL1_PONAB
AccessionPrimary (citable) accession number: Q5R9Y1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 19, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families