Q5R9W8 (XPP3_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase 3
Short name=X-Pro aminopeptidase 3
EC=3.4.11.9

Alternative name(s):
Aminopeptidase P3
Short name=APP3

Gene names

Name:

XPNPEP3

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Probable Xaa-Pro aminopeptidase 3		PRO_0000255655
Sites
	Metal binding	331	1	Manganese 2 By similarity
	Metal binding	342	1	Manganese 1 By similarity
	Metal binding	342	1	Manganese 2 By similarity
	Metal binding	424	1	Manganese 1 By similarity
	Metal binding	451	1	Manganese 1 By similarity
	Metal binding	475	1	Manganese 1 By similarity
	Metal binding	475	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R9W8 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: A51A46CCFDFDED1B	FASTA	507	57,032
	10 20 30 40 50 60 MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP 70 80 90 100 110 120 GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL SNPTYYMSND IPYTFHQDNN 130 140 150 160 170 180 FLYLCGFQEP DSILVLQSLP GKQLPSHKAI LFVPRRDPSR ELWDGPRSGT DGAIALTGVD 190 200 210 220 230 240 EAYTLEEFQH LLPKMKAETN MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI 250 260 270 280 290 300 QRLRLIKSPA EIERMQIAGK LTSQAFIETM FASKAPVEEG FLYAKFEFEC RARGADILAY 310 320 330 340 350 360 PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN GRFTAPQAEL 370 380 390 400 410 420 YEAILEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG IMKNIKENNA FKAARKYCPH 430 440 450 460 470 480 HVGHYLGMDV HDTPDMPRSL PLQPGMVITI EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV 490 500 TQDSPLILSA DCPKEMNDIE QICSRAS

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR859263 mRNA. Translation: CAH91442.1.
RefSeq	NP_001127419.1. NM_001133947.1.
UniGene	Pab.19037.
3D structure databases
HSSP	HSSP built from PDB template 1PV9 based on UniProtKB P81535.
ProteinModelPortal	Q5R9W8.
ModBase	Search...
Protein family/group databases
MEROPS	M24.026.
Proteomic databases
PRIDE	Q5R9W8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100174489.
KEGG	pon:100174489.
Organism-specific databases
CTD	63929.
Phylogenomic databases
HOVERGEN	HBG057305.
InParanoid	Q5R9W8.
KO	K01262.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
ProtoNet	Search...

Entry information

Entry name

XPP3_PONAB

Accession

Primary (citable) accession number: Q5R9W8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	December 21, 2004
Last modified:	March 6, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program