SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5R9V6

- NEUL_PONAB

UniProt

Q5R9V6 - NEUL_PONAB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Neurolysin, mitochondrial
Gene
NLN
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A By similarity.

Catalytic activityi

Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi497 – 4971Zinc; catalytic By similarity
Active sitei498 – 4981 By similarity
Metal bindingi501 – 5011Zinc; catalytic By similarity
Metal bindingi504 – 5041Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurolysin, mitochondrial (EC:3.4.24.16)
Alternative name(s):
Microsomal endopeptidase
Short name:
MEP
Mitochondrial oligopeptidase M
Neurotensin endopeptidase
Gene namesi
Name:NLN
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Mitochondrion intermembrane space By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. mitochondrial intermembrane space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737Mitochondrion
Add
BLAST
Chaini38 – 704667Neurolysin, mitochondrial
PRO_0000319048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei664 – 6641N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ5R9V6.

Structurei

3D structure databases

ProteinModelPortaliQ5R9V6.
SMRiQ5R9V6. Positions 37-701.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG000238.
KOiK01393.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R9V6-1 [UniParc]FASTAAdd to Basket

« Hide

MIARCLLAVR SLRRVGGSRI LLRMTLGREV MSPLQAMSSY TVTGRNVLRW    50
DLSPEQIKTR TEELIVQTKQ VYDAVGMLGI EEVTYENCLQ ALADIEVKYI 100
VERTMLDFPQ HVSSDKEVRA ASTEADKRLS RFDIEMSMRG DIFERIVRLQ 150
ETCDLGKIKP EARRYLEKSI KMGKRNGLHL PEQVQNEIKS MKKRMSELCI 200
DFNKNLNEDD TFLVFSKAEL GALPDDFIDS LEKIDDDKYK ITLKYPHYFP 250
VMKKCCIPET RRRMEMAFNT RCKEENTIIL QQLLPLRAKV AKLLGYSTHA 300
DFVLEMNTAK STSRVTAFLD DLSQKLKPLG EAEREFILNL KKKECEDRGF 350
EYDGKINAWD LYYYMTQTEE LKYSIDQEFL KEYFPIEVVT EGLLNTYQEL 400
LGLSFEQVTD AHVWNKNVTL YTVKDKATGE VLGQFYLDLY PRDRKYNHAA 450
CFGLQPGCLL PDGSRMMAVA ALVVNFSQPV AGRPSLLRHD EVRTYFHEFG 500
HVMHQICAQT DFARFSGTNV ETDFVEVPSQ MLENWVWDVD SLRRLSKHYK 550
DGSPISDDLL EKLVASRLIN TGLLTLRQIV LSKVDQSLHT NTSLDAASEY 600
AKYCSEILGV AATPGTNMPA TFGHLAGGYD GQYYGYLWSE VFSMDMFYSC 650
FKKEGIMNPE VGMKYRNLIL KPGGSLDGMD MLHNFLKREP NQKAFLMSRG 700
LHAS 704
Length:704
Mass (Da):80,798
Last modified:December 21, 2004 - v1
Checksum:iCDE234F0F169D7C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859276 mRNA. Translation: CAH91454.1.
RefSeqiNP_001127421.1. NM_001133949.2.
UniGeneiPab.7982.

Genome annotation databases

GeneIDi100174491.
KEGGipon:100174491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859276 mRNA. Translation: CAH91454.1 .
RefSeqi NP_001127421.1. NM_001133949.2.
UniGenei Pab.7982.

3D structure databases

ProteinModelPortali Q5R9V6.
SMRi Q5R9V6. Positions 37-701.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M03.002.

Proteomic databases

PRIDEi Q5R9V6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100174491.
KEGGi pon:100174491.

Organism-specific databases

CTDi 57486.

Phylogenomic databases

HOVERGENi HBG000238.
KOi K01393.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiNEUL_PONAB
AccessioniPrimary (citable) accession number: Q5R9V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 21, 2004
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi