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Protein

Vacuolar protein sorting-associated protein 37C

Gene

VPS37C

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37C
Alternative name(s):
ESCRT-I complex subunit VPS37C
Gene namesi
Name:VPS37C
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003122001 – 355Vacuolar protein sorting-associated protein 37CAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by TBK1.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with HGS and STAM2. Interacts with CEP55 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000003686

Structurei

3D structure databases

ProteinModelPortaliQ5R9T2
SMRiQ5R9T2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 167VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi171 – 353Pro-richAdd BLAST183

Sequence similaritiesi

Belongs to the VPS37 family.Curated

Phylogenomic databases

eggNOGiKOG3270 Eukaryota
ENOG4111UJN LUCA
HOVERGENiHBG073355
InParanoidiQ5R9T2
KOiK12185

Family and domain databases

InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR009851 Mod_r
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R9T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLKDKTLQ ELEELQNDSE AIDQLALESP EVQDLQLERE MALATNRSLA
60 70 80 90 100
ERNLEFQGPL EISRSNLSDK YQELRKLVER CQEQKAKLEK FSSALQPGTL
110 120 130 140 150
LDLLQVEGMK IEGESEAMAE KFLEGEVPLE TFLENFSSMR MLSHLRRVRV
160 170 180 190 200
EKLQEVVRKP RASQELAGDA PPPRPPPPVR PVPQGTPPVV EEQPQPPSAM
210 220 230 240 250
PPYPLPYSLS PSLPVGSTAH GALPPAPFPV VSQPSFYSGP LGPTYPAAQP
260 270 280 290 300
GPRGAAGYSW SPQRSTPPRP GYPGTPTGAS GPGYPLAGGR ALSPGYPQQS
310 320 330 340 350
PYPATGGKPP YPIQPQLPSF PGQPQPSVPL QPPYPPGPAP PYGFPPPPGP

AWPGY
Length:355
Mass (Da):38,394
Last modified:December 21, 2004 - v1
Checksum:i1BF12B70E94C5788
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859300 mRNA Translation: CAH91478.1
RefSeqiNP_001125870.1, NM_001132398.1
UniGeneiPab.9211

Genome annotation databases

GeneIDi100172801
KEGGipon:100172801

Similar proteinsi

Entry informationi

Entry nameiVP37C_PONAB
AccessioniPrimary (citable) accession number: Q5R9T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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