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Protein

26S proteasome non-ATPase regulatory subunit 2

Gene

PSMD2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 2
Gene namesi
Name:PSMD2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899981 – 90826S proteasome non-ATPase regulatory subunit 2Add BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei24PhosphothreonineBy similarity1
Modified residuei29PhosphoserineBy similarity1
Modified residuei147PhosphoserineBy similarity1
Modified residuei194PhosphotyrosineBy similarity1
Modified residuei361PhosphoserineBy similarity1
Modified residuei363PhosphoserineBy similarity1
Modified residuei551N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ5R9I6.

Interactioni

Subunit structurei

Interacts with RPGRIP1L.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000016052.

Structurei

3D structure databases

ProteinModelPortaliQ5R9I6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati409 – 442PC 1Add BLAST34
Repeati443 – 479PC 2Add BLAST37
Repeati480 – 514PC 3Add BLAST35
Repeati517 – 551PC 4Add BLAST35
Repeati560 – 589PC 5Add BLAST30
Repeati692 – 723PC 6Add BLAST32
Repeati742 – 757PC 7Add BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi623 – 641Glu/Lys-richAdd BLAST19

Sequence similaritiesi

Belongs to the proteasome subunit S2 family.Curated
Contains 7 PC repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2005. Eukaryota.
COG5110. LUCA.
HOVERGENiHBG001842.
InParanoidiQ5R9I6.
KOiK03028.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR016643. 26S_Psome_Rpn1.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002015. Proteasome/cyclosome_rpt.
[Graphical view]
PfamiPF01851. PC_rep. 2 hits.
[Graphical view]
PIRSFiPIRSF015965. 26S_Psome_Rpn1. 1 hit.
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

Q5R9I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGGRDKAP VQPQQSPAAA LGGTDEKPSG KERRDAGDKD KEQELSEEDK
60 70 80 90 100
QLQDELEMLV ERLGEKDTSL YRPALEELRR QIRSSTTSMT SVPKPLKFLR
110 120 130 140 150
PHYGKLKEIY ENMAPGENKR FAADIISVLA MTMSGERECL KYRLVGSQEE
160 170 180 190 200
LASWGHEYVR HLAGEVAKEW QELDDAEKVQ REPLLTLVKE IIPYNMAHNA
210 220 230 240 250
EHEACDLLME IEQVDMLEKD IDENAYAKVC LYLTSCVNYV PEPENSALLR
260 270 280 290 300
CALGVFRKFS RFPEALRLAL MLNDMELVED IFTSCKDVVV QKQMAFMLGR
310 320 330 340 350
HGVFLELSED VEEYEDLTEI MSNVQLNSNF LALARELDIM EPKVPDDIYK
360 370 380 390 400
THLENNRFGG SGSQVDSARM NLASSFVNGF VNAAFGQDKL LTDDGNKWLY
410 420 430 440 450
KNKDHGMLSA AASLGMILLW DVDGGLTQID KYLYSSEDYI KSGALLACGI
460 470 480 490 500
VNSGVRNECD PALALLSDYV LHNSNTMRLG SIFGLGLAYA GSNREDVLTL
510 520 530 540 550
LLPVMGDSKS SMEVAGVTAL ACGMIAVGSC NGDVTSTILQ TIMEKSETEL
560 570 580 590 600
KDTYARWLPL GLGLNHLGKG EAIEAILAAL EVVSEPFRSF ANTLVDVCAY
610 620 630 640 650
AGSGNVLKVQ QLLHICSEHF DSKEKEEDKD KKEKKDKDKK EAPADMGAHQ
660 670 680 690 700
GVAVLGIALI AMGEEIGAEM ALRTFGHLLR YGEPTLRRAV PLALALISVS
710 720 730 740 750
NPRLNILDTL SKFSHDADPE VSYNSIFAMG MVGSGTNNAR LAAMLRQLAQ
760 770 780 790 800
YHAKDPNNLF MVRLAQGLTH LGKGTLTLCP YHSDRQLMSQ VAVAGLLTVL
810 820 830 840 850
VSFLDVRNII LGKSHYVLYG LVAAMQPRML VTFDEELRPL PVSVRVGQAV
860 870 880 890 900
DVVGQAGKPK TITGFQTHTT PVLLAHGERA ELATEEFLPV TPILEGFVIL

RKNPNYDL
Length:908
Mass (Da):100,230
Last modified:December 21, 2004 - v1
Checksum:i3599E54B84737A5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859401 mRNA. Translation: CAH91574.1.
CR859332 mRNA. Translation: CAH91509.1.
RefSeqiNP_001125887.1. NM_001132415.1.

Genome annotation databases

GeneIDi100172819.
KEGGipon:100172819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859401 mRNA. Translation: CAH91574.1.
CR859332 mRNA. Translation: CAH91509.1.
RefSeqiNP_001125887.1. NM_001132415.1.

3D structure databases

ProteinModelPortaliQ5R9I6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000016052.

Proteomic databases

PRIDEiQ5R9I6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100172819.
KEGGipon:100172819.

Organism-specific databases

CTDi5708.

Phylogenomic databases

eggNOGiKOG2005. Eukaryota.
COG5110. LUCA.
HOVERGENiHBG001842.
InParanoidiQ5R9I6.
KOiK03028.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR016643. 26S_Psome_Rpn1.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002015. Proteasome/cyclosome_rpt.
[Graphical view]
PfamiPF01851. PC_rep. 2 hits.
[Graphical view]
PIRSFiPIRSF015965. 26S_Psome_Rpn1. 1 hit.
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPSMD2_PONAB
AccessioniPrimary (citable) accession number: Q5R9I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.