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Q5R9G0

- RIR2B_PONAB

UniProt

Q5R9G0 - RIR2B_PONAB

Protein

Ribonucleoside-diphosphate reductase subunit M2 B

Gene

RRM2B

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi100 – 1001Iron 1PROSITE-ProRule annotation
    Metal bindingi131 – 1311Iron 1PROSITE-ProRule annotation
    Metal bindingi131 – 1311Iron 2By similarity
    Metal bindingi134 – 1341Iron 1PROSITE-ProRule annotation
    Active sitei138 – 1381PROSITE-ProRule annotation
    Metal bindingi194 – 1941Iron 2By similarity
    Metal bindingi228 – 2281Iron 2By similarity
    Metal bindingi231 – 2311Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. deoxyribonucleoside triphosphate metabolic process Source: Ensembl
    3. deoxyribonucleotide biosynthetic process Source: Ensembl
    4. DNA repair Source: UniProtKB-KW
    5. kidney development Source: Ensembl
    6. mitochondrial DNA replication Source: Ensembl
    7. negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
    8. renal system process Source: Ensembl
    9. response to oxidative stress Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA damage, DNA repair, DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit M2 B (EC:1.17.4.1)
    Gene namesi
    Name:RRM2B
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 8

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Translocates from cytoplasm to nucleus in response to DNA damage.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Ribonucleoside-diphosphate reductase subunit M2 BPRO_0000228153Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer with large (RRM1) subunit. Interacts with p53/TP53. Interacts with RRM1 in response to DNA damage By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R9G0.
    SMRiQ5R9G0. Positions 30-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00390000013305.
    HOVERGENiHBG001647.
    InParanoidiQ5R9G0.
    KOiK10808.
    OMAiCLMFHYL.
    OrthoDBiEOG7VMP5N.
    TreeFamiTF300465.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5R9G0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDPERPEAA GLDQDERSSS DTNENEIKSN EEPLLRKSSR RFVIFPIQYP    50
    DIWKMYKQAQ ASFWTAEEVD LSKDLPHWNK LKADEKYFIS HILAFFAASD 100
    GIVNENLVER FSQEVQVPEA RCFYGFQILI ENVHSEMYSL LIDTYIRDPK 150
    KREFLFNAIE TMPYVKKKAD WALRWIADRK STFGERVVAF AAVEGVFFSG 200
    SFAAIFWLKK RGLMPGLTFS NELISRDEGL HCDFACLMFQ YLVNKPSEER 250
    VREIIVDAVK IEQEFLTEAL PVGLIGMNCI LMKQYIEFVA DRLLVELGFS 300
    KVFQAENPFD FMENISLEGK TNFFEKRVSE YQRFAVMAET TDNVFTLDAD 350
    F 351
    Length:351
    Mass (Da):40,764
    Last modified:December 21, 2004 - v1
    Checksum:i55CB774EE0CBF179
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859428 mRNA. Translation: CAH91600.1.
    RefSeqiNP_001125944.1. NM_001132472.1.
    UniGeneiPab.3032.

    Genome annotation databases

    EnsembliENSPPYT00000021926; ENSPPYP00000021083; ENSPPYG00000018796.
    GeneIDi100172878.
    KEGGipon:100172878.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859428 mRNA. Translation: CAH91600.1 .
    RefSeqi NP_001125944.1. NM_001132472.1.
    UniGenei Pab.3032.

    3D structure databases

    ProteinModelPortali Q5R9G0.
    SMRi Q5R9G0. Positions 30-312.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000021926 ; ENSPPYP00000021083 ; ENSPPYG00000018796 .
    GeneIDi 100172878.
    KEGGi pon:100172878.

    Organism-specific databases

    CTDi 50484.

    Phylogenomic databases

    GeneTreei ENSGT00390000013305.
    HOVERGENi HBG001647.
    InParanoidi Q5R9G0.
    KOi K10808.
    OMAi CLMFHYL.
    OrthoDBi EOG7VMP5N.
    TreeFami TF300465.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiRIR2B_PONAB
    AccessioniPrimary (citable) accession number: Q5R9G0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3