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Q5R9G0 (RIR2B_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit M2 B

EC=1.17.4.1
Gene names
Name:RRM2B
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterotetramer with large (RRM1) subunit. Interacts with p53/TP53. Interacts with RRM1 in response to DNA damage By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Translocates from cytoplasm to nucleus in response to DNA damage By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Ribonucleoside-diphosphate reductase subunit M2 B
PRO_0000228153

Sites

Active site1381 By similarity
Metal binding1001Iron 1 By similarity
Metal binding1311Iron 1 By similarity
Metal binding1311Iron 2 By similarity
Metal binding1341Iron 1 By similarity
Metal binding1941Iron 2 By similarity
Metal binding2281Iron 2 By similarity
Metal binding2311Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R9G0 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 55CB774EE0CBF179

FASTA35140,764
        10         20         30         40         50         60 
MGDPERPEAA GLDQDERSSS DTNENEIKSN EEPLLRKSSR RFVIFPIQYP DIWKMYKQAQ 

        70         80         90        100        110        120 
ASFWTAEEVD LSKDLPHWNK LKADEKYFIS HILAFFAASD GIVNENLVER FSQEVQVPEA 

       130        140        150        160        170        180 
RCFYGFQILI ENVHSEMYSL LIDTYIRDPK KREFLFNAIE TMPYVKKKAD WALRWIADRK 

       190        200        210        220        230        240 
STFGERVVAF AAVEGVFFSG SFAAIFWLKK RGLMPGLTFS NELISRDEGL HCDFACLMFQ 

       250        260        270        280        290        300 
YLVNKPSEER VREIIVDAVK IEQEFLTEAL PVGLIGMNCI LMKQYIEFVA DRLLVELGFS 

       310        320        330        340        350 
KVFQAENPFD FMENISLEGK TNFFEKRVSE YQRFAVMAET TDNVFTLDAD F 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR859428 mRNA. Translation: CAH91600.1.
RefSeqNP_001125944.1. NM_001132472.1.
UniGenePab.3032.

3D structure databases

ProteinModelPortalQ5R9G0.
SMRQ5R9G0. Positions 30-312.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000021926; ENSPPYP00000021083; ENSPPYG00000018796.
GeneID100172878.
KEGGpon:100172878.

Organism-specific databases

CTD50484.

Phylogenomic databases

GeneTreeENSGT00390000013305.
HOVERGENHBG001647.
InParanoidQ5R9G0.
KOK10808.
OMAKIFNTEA.
OrthoDBEOG7VMP5N.
TreeFamTF300465.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2B_PONAB
AccessionPrimary (citable) accession number: Q5R9G0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways