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Protein

Corticosteroid-binding globulin

Gene

SERPINA6

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei250 – 2501Conserved cysteine within steroid binding domainBy similarity
Binding sitei286 – 2861CorticosteroidBy similarity
Binding sitei393 – 3931CorticosteroidBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding, Steroid-binding

Protein family/group databases

MEROPSiI04.954.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticosteroid-binding globulin
Short name:
CBG
Alternative name(s):
Serpin A6
Transcortin
Gene namesi
Name:SERPINA6
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 405383Corticosteroid-binding globulinPRO_0000230781Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000006937.

Structurei

3D structure databases

ProteinModelPortaliQ5R9E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids (By similarity).By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOVERGENiHBG005957.
InParanoidiQ5R9E3.
KOiK04525.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R9E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLLYTCLL WLSTSGLWTV QAMDPNTTYV NMSNHHRGLA SANVDFAFSL
60 70 80 90 100
YKHLVALSPK KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTGR
110 120 130 140 150
SETEIHQGFQ HLHQLFAESD TSLEMTMGNA LFLDGSLELL ESFSADIKHY
160 170 180 190 200
YESEVLAMNF QDWATASRQI NSYVKSKTQG KIADLLSGLD SPAILVLVNY
210 220 230 240 250
IFFKGTWTQP FDLASTREEN FYVDETTVVK VPMMLQSSTI SYLHDSELPC
260 270 280 290 300
QLVRLNYVGN GTVFFILPEK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY
310 320 330 340 350
IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV
360 370 380 390 400
LQLNEEGVDT AGSTGVTLNL TSKPIILRFN QPFIIMIFDH FTWSSLFLAR

VVNPA
Length:405
Mass (Da):44,995
Last modified:December 21, 2004 - v1
Checksum:i07FDB129129F24F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859446 mRNA. Translation: CAH91617.1.
RefSeqiNP_001125953.1. NM_001132481.1.

Genome annotation databases

GeneIDi100172888.
KEGGipon:100172888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859446 mRNA. Translation: CAH91617.1.
RefSeqiNP_001125953.1. NM_001132481.1.

3D structure databases

ProteinModelPortaliQ5R9E3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000006937.

Protein family/group databases

MEROPSiI04.954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100172888.
KEGGipon:100172888.

Organism-specific databases

CTDi866.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOVERGENiHBG005957.
InParanoidiQ5R9E3.
KOiK04525.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCBG_PONAB
AccessioniPrimary (citable) accession number: Q5R9E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: November 11, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.