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UniProtKB/Swiss-Prot Q5R9C1 (F263_PONAB)
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February 9, 2010.
Version 26.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Short name=6PF-2-K/Fru-2,6-P2ase 3 Short name=PFK/FBPase 3 Alternative name(s): 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme Including the following 2 domains: 1- Recommended name: 6-phosphofructo-2-kinase EC=2.7.1.105 2- Recommended name: Fructose-2,6-bisphosphatase EC=3.1.3.46 | ||
| Gene names |
| ||
| Organism | Pongo abelii (Sumatran orangutan) | ||
| Taxonomic identifier | 9601 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Protein attributes
| Sequence length | 514 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Synthesis and degradation of fructose 2,6-bisphosphate By similarity. |
| Catalytic activity | Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate. |
| Sequence similarities | In the C-terminal section; belongs to the phosphoglycerate mutase family. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Hydrolase Kinase Transferase |
| PTM | Phosphoprotein |
| Technical term | Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | fructose 2,6-bisphosphate metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | 6-phosphofructo-2-kinase activity Inferred from electronic annotation. Source: EC ATP bindingInferred from electronic annotation. Source: UniProtKB-KW fructose-2,6-bisphosphate 2-phosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q5R9C1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q5R9C1-2) The sequence of this isoform differs from the canonical sequence as follows: 3-26: LELTQSRVQKIWVPVDHRPSLPRS → FRKA 506-514: PLLGQACLT → NMKGSRSSADSSRKH | ||||||
| Isoform 3 (identifier: Q5R9C1-3) The sequence of this isoform differs from the canonical sequence as follows: 3-26: LELTQSRVQKIWVPVDHRPSLPRS → FRKA 514-514: T → RTVCHIFSKFSPY |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 514 | 514 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | PRO_0000345149 | |||||
Regions | |||||||||
| Nucleotide binding | 42 – 49 | 8 | ATP By similarity | ||||||
| Region | 1 – 245 | 245 | 6-phosphofructo-2-kinase | ||||||
| Region | 246 – 514 | 269 | Fructose-2,6-bisphosphatase | ||||||
Sites | |||||||||
| Active site | 125 | 1 | Potential | ||||||
| Active site | 155 | 1 | Potential | ||||||
| Active site | 254 | 1 | Tele-phosphohistidine intermediate By similarity | ||||||
| Active site | 323 | 1 | Potential | ||||||
| Active site | 388 | 1 | Proton donor By similarity | ||||||
| Binding site | 99 | 1 | Fructose-6-phosphate By similarity | ||||||
| Binding site | 190 | 1 | Fructose-6-phosphate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 461 | 1 | Phosphoserine; by PKA By similarity | ||||||
| Modified residue | 463 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 467 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 471 | 1 | Phosphothreonine; by PKC By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 3 – 26 | 24 | LELTQ…SLPRS → FRKA in isoform 2 and isoform 3. | VSP_034919 | |||||
| Alternative sequence | 506 – 514 | 9 | PLLGQACLT → NMKGSRSSADSSRKH in isoform 2. | VSP_034920 | |||||
| Alternative sequence | 514 | 1 | T → RTVCHIFSKFSPY in isoform 3. | VSP_034921 | |||||
Experimental info | |||||||||
| Sequence conflict | 37 | 1 | V → A in CAH92952. Ref.1 | ||||||
| Sequence conflict | 224 | 1 | V → A in CAH93512. Ref.1 | ||||||
| Sequence conflict | 326 | 1 | A → V in CAH91639. Ref.1 | ||||||
Sequences
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References
| [1] | The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Brain cortex and Kidney. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR859468 mRNA. Translation: CAH91639.1. CR860843 mRNA. Translation: CAH92952.1. CR861456 mRNA. Translation: CAH93512.1. |
| RefSeq | NP_001125963.1. NP_001128959.1. |
| UniGene | Pab.18003 Pab.853 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2AXN based on UniProtKB Q16875. |
| SMR | Q5R9C1. Positions 3-461. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 100172898. |
Organism-specific databases | |
| CTD | 100172898. |
Phylogenomic databases | |
| HOVERGEN | Q5R9C1. |
Family and domain databases | |
| InterPro | IPR003094. 6Pfruct_kin. IPR013079. 6Phosfructo_kin. IPR016260. Bifunct_6PFK/fruc_bisP_Ptase. IPR001345. PG/BPGM_mutase_AS. IPR013078. PG_mutase. [Graphical view] |
| PANTHER | PTHR10606. 6Pfruct_kin. 1 hit. |
| Pfam | PF01591. 6PF2K. 1 hit. PF00300. PGAM. 1 hit. [Graphical view] |
| PIRSF | PIRSF000709. 6PFK_2-Ptase. 1 hit. |
| PRINTS | PR00991. 6PFRUCTKNASE. |
| SMART | SM00855. PGAM. 1 hit. [Graphical view] |
| PROSITE | PS00175. PG_MUTASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | F263_PONAB | ||||||||
| Accession | Primary (citable) accession number: Q5R9C1 Secondary accession number(s): Q5R404, Q5R5L4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
