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Q5R8U1 (GALM_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldose 1-epimerase

EC=5.1.3.3
Alternative name(s):
Galactose mutarotase
Gene names
Name:GALM
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose By similarity.

Catalytic activity

Alpha-D-glucose = beta-D-glucose.

Pathway

Carbohydrate metabolism; hexose metabolism.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the aldose epimerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   Molecular functionIsomerase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhexose metabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaldose 1-epimerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

carbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 342341Aldose 1-epimerase
PRO_0000197436

Regions

Region81 – 822Substrate binding By similarity

Sites

Active site1761Proton donor By similarity
Active site3071Proton acceptor By similarity
Binding site2431Substrate By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R8U1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: D00C2A67753D6DFF

FASTA34237,819
        10         20         30         40         50         60 
MASATRAVFG ELPSGGGTVE KFQLQSDLLR VDIISWGCTI TALEVKDRQG RSSDVVLGFA 

        70         80         90        100        110        120 
ELEGYLQKQP YFGAVIGRVA NRIAKGTFKV DGKEYHLAIN KEPNSLHGGV RGFDKVLWTP 

       130        140        150        160        170        180 
RVLSNGIQFS RISPDGEEGY PGELKVWVTY TLDGGELVVN YRAQASQATP VNLTNHSYFN 

       190        200        210        220        230        240 
LAGQGSPNIY DHEVTIEADT YLPVDETLIP TGEVAPVQGT AFDLRKPVEL GKHLQDFHLN 

       250        260        270        280        290        300 
GFDHNFCLKG SKEKHFCARV HHAASGRVLE VYTTQPGVQF YMGNFLDGTL KGKNGAVYPK 

       310        320        330        340 
HSGFCLETQN WPDAVNQPRF PPVLLRPGEE YDHTTWFKFS VA 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR859658 mRNA. Translation: CAH91819.1.
RefSeqNP_001126052.1. NM_001132580.1.
UniGenePab.14287.

3D structure databases

ProteinModelPortalQ5R8U1.
SMRQ5R8U1. Positions 1-342.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173004.
KEGGpon:100173004.

Organism-specific databases

CTD130589.

Phylogenomic databases

HOVERGENHBG051697.
InParanoidQ5R8U1.
KOK01785.

Enzyme and pathway databases

UniPathwayUPA00242.

Family and domain databases

Gene3D2.70.98.10. 1 hit.
InterProIPR018052. Ald1_epimerase_CS.
IPR015443. Aldose_1-epimerase.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PANTHERPTHR10091. PTHR10091. 1 hit.
PfamPF01263. Aldose_epim. 1 hit.
[Graphical view]
PIRSFPIRSF005096. GALM. 1 hit.
SUPFAMSSF74650. SSF74650. 1 hit.
PROSITEPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGALM_PONAB
AccessionPrimary (citable) accession number: Q5R8U1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 21, 2004
Last modified: October 16, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways