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Q5R8R5

- GSTP1_PONAB

UniProt

Q5R8R5 - GSTP1_PONAB

Protein

Glutathione S-transferase P

Gene

GSTP1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration By similarity.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 81GlutathioneBy similarity
    Binding sitei14 – 141GlutathioneBy similarity
    Binding sitei39 – 391GlutathioneBy similarity
    Binding sitei45 – 451GlutathioneBy similarity

    GO - Molecular functioni

    1. dinitrosyl-iron complex binding Source: Ensembl
    2. glutathione transferase activity Source: UniProtKB-EC
    3. S-nitrosoglutathione binding Source: Ensembl

    GO - Biological processi

    1. glutathione metabolic process Source: Ensembl
    2. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
    3. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    4. negative regulation of interleukin-1 beta production Source: Ensembl
    5. negative regulation of JUN kinase activity Source: Ensembl
    6. negative regulation of monocyte chemotactic protein-1 production Source: Ensembl
    7. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    8. negative regulation of tumor necrosis factor production Source: Ensembl
    9. xenobiotic metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase P (EC:2.5.1.18)
    Alternative name(s):
    GST class-pi
    Gene namesi
    Name:GSTP1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Mitochondrion By similarity. Nucleus By similarity
    Note: The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. TRAF2-GSTP1 complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 210209Glutathione S-transferase PPRO_0000185906Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei4 – 41Phosphotyrosine; by EGFRBy similarity
    Modified residuei103 – 1031N6-succinyllysineBy similarity
    Modified residuei116 – 1161N6-succinyllysineBy similarity
    Modified residuei128 – 1281N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CDK5.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R8R5.
    SMRiQ5R8R5. Positions 1-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8180GST N-terminalAdd
    BLAST
    Domaini83 – 204122GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni52 – 532Glutathione bindingBy similarity
    Regioni65 – 662Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Pi family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    HOVERGENiHBG108324.
    KOiK00799.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003082. GST_pi.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01268. GSTRNSFRASEP.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R8R5-1 [UniParc]FASTAAdd to Basket

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    MPPYTVVYFP VRGRCAALRM LLADQGQSWK EEVVSMETWQ EGSLKASCLY    50
    GQLPKFQDGD LTLYQSNTIL RHLGRTLGLY GKDQREAALV DMVNDGVEDL 100
    RCKYLSLIYT NYEAGKDDYV KALPGQLKPF ETLLSQNQGG KTFIVGDQIS 150
    FADYNLLDLL LIHEVLAPGC LDAFPLLSAY VARLSARPKL KAFLASPEHV 200
    NLPINGNGKQ 210
    Length:210
    Mass (Da):23,390
    Last modified:January 23, 2007 - v3
    Checksum:i56337AEA78462CEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859686 mRNA. Translation: CAH91845.1.
    RefSeqiNP_001127471.1. NM_001133999.1.

    Genome annotation databases

    GeneIDi100174544.
    KEGGipon:100174544.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859686 mRNA. Translation: CAH91845.1 .
    RefSeqi NP_001127471.1. NM_001133999.1.

    3D structure databases

    ProteinModelPortali Q5R8R5.
    SMRi Q5R8R5. Positions 1-210.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100174544.
    KEGGi pon:100174544.

    Organism-specific databases

    CTDi 2950.

    Phylogenomic databases

    HOVERGENi HBG108324.
    KOi K00799.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003082. GST_pi.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01268. GSTRNSFRASEP.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiGSTP1_PONAB
    AccessioniPrimary (citable) accession number: Q5R8R5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3