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Protein

Glutathione S-transferase P

Gene

GSTP1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei14GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18)
Alternative name(s):
GST class-pi
Gene namesi
Name:GSTP1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859061 – 210Glutathione S-transferase PAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4Phosphotyrosine; by EGFRBy similarity1
Modified residuei62PhosphothreonineBy similarity1
Modified residuei103N6-succinyllysineBy similarity1
Modified residuei116N6-succinyllysineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Homodimer. Interacts with CDK5.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000003460.

Structurei

3D structure databases

ProteinModelPortaliQ5R8R5.
SMRiQ5R8R5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 81GST N-terminalAdd BLAST80
Domaini83 – 204GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 53Glutathione bindingBy similarity2
Regioni65 – 66Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
HOVERGENiHBG108324.
InParanoidiQ5R8R5.
KOiK00799.
OrthoDBiEOG091G0K2E.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R8R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPYTVVYFP VRGRCAALRM LLADQGQSWK EEVVSMETWQ EGSLKASCLY
60 70 80 90 100
GQLPKFQDGD LTLYQSNTIL RHLGRTLGLY GKDQREAALV DMVNDGVEDL
110 120 130 140 150
RCKYLSLIYT NYEAGKDDYV KALPGQLKPF ETLLSQNQGG KTFIVGDQIS
160 170 180 190 200
FADYNLLDLL LIHEVLAPGC LDAFPLLSAY VARLSARPKL KAFLASPEHV
210
NLPINGNGKQ
Length:210
Mass (Da):23,390
Last modified:January 23, 2007 - v3
Checksum:i56337AEA78462CEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859686 mRNA. Translation: CAH91845.1.
RefSeqiNP_001127471.1. NM_001133999.1.

Genome annotation databases

GeneIDi100174544.
KEGGipon:100174544.

Similar proteinsi

Entry informationi

Entry nameiGSTP1_PONAB
AccessioniPrimary (citable) accession number: Q5R8R5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 87 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families