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Q5R8R5

- GSTP1_PONAB

UniProt

Q5R8R5 - GSTP1_PONAB

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Protein
Glutathione S-transferase P
Gene
GSTP1
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81Glutathione By similarity
Binding sitei14 – 141Glutathione By similarity
Binding sitei39 – 391Glutathione By similarity
Binding sitei45 – 451Glutathione By similarity

GO - Molecular functioni

  1. S-nitrosoglutathione binding Source: Ensembl
  2. dinitrosyl-iron complex binding Source: Ensembl
  3. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutathione metabolic process Source: Ensembl
  2. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  3. negative regulation of JUN kinase activity Source: Ensembl
  4. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  5. negative regulation of interleukin-1 beta production Source: Ensembl
  6. negative regulation of monocyte chemotactic protein-1 production Source: Ensembl
  7. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  8. negative regulation of tumor necrosis factor production Source: Ensembl
  9. xenobiotic metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18)
Alternative name(s):
GST class-pi
Gene namesi
Name:GSTP1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Cytoplasm By similarity. Mitochondrion By similarity. Nucleus By similarity
Note: The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization By similarity.

GO - Cellular componenti

  1. TRAF2-GSTP1 complex Source: Ensembl
  2. mitochondrion Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 210209Glutathione S-transferase P
PRO_0000185906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41Phosphotyrosine; by EGFR By similarity
Modified residuei103 – 1031N6-succinyllysine By similarity
Modified residuei116 – 1161N6-succinyllysine By similarity
Modified residuei128 – 1281N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Homodimer By similarity. Interacts with CDK5 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5R8R5.
SMRiQ5R8R5. Positions 1-210.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8180GST N-terminal
Add
BLAST
Domaini83 – 204122GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 532Glutathione binding By similarity
Regioni65 – 662Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.

Phylogenomic databases

HOVERGENiHBG108324.
KOiK00799.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R8R5-1 [UniParc]FASTAAdd to Basket

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MPPYTVVYFP VRGRCAALRM LLADQGQSWK EEVVSMETWQ EGSLKASCLY    50
GQLPKFQDGD LTLYQSNTIL RHLGRTLGLY GKDQREAALV DMVNDGVEDL 100
RCKYLSLIYT NYEAGKDDYV KALPGQLKPF ETLLSQNQGG KTFIVGDQIS 150
FADYNLLDLL LIHEVLAPGC LDAFPLLSAY VARLSARPKL KAFLASPEHV 200
NLPINGNGKQ 210
Length:210
Mass (Da):23,390
Last modified:January 23, 2007 - v3
Checksum:i56337AEA78462CEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859686 mRNA. Translation: CAH91845.1.
RefSeqiNP_001127471.1. NM_001133999.1.

Genome annotation databases

GeneIDi100174544.
KEGGipon:100174544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859686 mRNA. Translation: CAH91845.1 .
RefSeqi NP_001127471.1. NM_001133999.1.

3D structure databases

ProteinModelPortali Q5R8R5.
SMRi Q5R8R5. Positions 1-210.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100174544.
KEGGi pon:100174544.

Organism-specific databases

CTDi 2950.

Phylogenomic databases

HOVERGENi HBG108324.
KOi K00799.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01268. GSTRNSFRASEP.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiGSTP1_PONAB
AccessioniPrimary (citable) accession number: Q5R8R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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