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Protein

GTP-binding protein 1

Gene

GTPBP1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107GTPSequence analysis8
Nucleotide bindingi185 – 189GTPSequence analysis5
Nucleotide bindingi241 – 244GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 1
Gene namesi
Name:GTPBP1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000122471‹1 – 602GTP-binding protein 1Add BLAST›602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei513PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with AANAT mRNA, but does not bind mRNA by itself (By similarity).By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000013394.

Structurei

3D structure databases

ProteinModelPortaliQ5R8Q7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 322tr-type GPROSITE-ProRule annotationAdd BLAST232

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 107G1PROSITE-ProRule annotation8
Regioni139 – 143G2PROSITE-ProRule annotation5
Regioni185 – 188G3PROSITE-ProRule annotation4
Regioni241 – 244G4PROSITE-ProRule annotation4
Regioni299 – 301G5PROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
HOVERGENiHBG004471.
InParanoidiQ5R8Q7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5R8Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VSPTSEQYDS LLRQMWERMD EGCGGTIYVI GQGSDGTEYG LSEADMEASY
60 70 80 90 100
ATVKSMAEQI EADVILLRER QEAGGRVRDY LVRKRVGDND FLEVRVAVVG
110 120 130 140 150
NVDAGKSTLL GVLTHGELDN GRGFARQKLF RHKHEIESGR TSSVGNDILG
160 170 180 190 200
FDSEGNVVNK PDSHGGSLEW TKICEKSTKV ITFIDLAGHE KYLKTTVFGM
210 220 230 240 250
TGHLPDFCML MVGSNAGIVG MTKEHLGLAL ALNVPVFVVV TKIDMCPANI
260 270 280 290 300
LQETLKLLQR LLKSPGCRKI PVLVQSKDDV IVTASNFSSE RMCPIFQISN
310 320 330 340 350
VTGENLDLLK MFLNLLSPRT SYREEEPAEF QIDDTYSVPG VGTVVSGTTL
360 370 380 390 400
RGLIKLNDTL LLGPDPLGNF LSIAVKSIHR KRMPVKEVRG GQTASFALKK
410 420 430 440 450
IKRSSIRKGM VMVSPRLNPQ ASWEFEAEIL VLHHPTTISP RYQAMVHCGS
460 470 480 490 500
IRQTATILSM DKDCLRTGDK ATVHFRFIKT PEYLHIDQRL VFREGRTKAV
510 520 530 540 550
GTITKLLQTT NNSPMNSKPQ QIKMQSTKKG PLTKRDEGGP SGGPAVGAPP
560 570 580 590 600
PGDEASSLGA GQPAASCNLQ PQPKPSSGGR RRGGQRYKVK SQGACVTPAS

GC
Length:602
Mass (Da):65,637
Last modified:September 5, 2006 - v2
Checksum:i767ADD2642F30E20
GO

Sequence cautioni

The sequence CAH91853 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859694 mRNA. Translation: CAH91853.1. Different initiation.
RefSeqiNP_001126073.1. NM_001132601.1.
UniGeneiPab.15991.

Genome annotation databases

GeneIDi100173025.
KEGGipon:100173025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859694 mRNA. Translation: CAH91853.1. Different initiation.
RefSeqiNP_001126073.1. NM_001132601.1.
UniGeneiPab.15991.

3D structure databases

ProteinModelPortaliQ5R8Q7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000013394.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100173025.
KEGGipon:100173025.

Organism-specific databases

CTDi9567.

Phylogenomic databases

eggNOGiKOG0463. Eukaryota.
COG5258. LUCA.
HOVERGENiHBG004471.
InParanoidiQ5R8Q7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTPB1_PONAB
AccessioniPrimary (citable) accession number: Q5R8Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 5, 2006
Last modified: July 6, 2016
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.