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Q5R8K7

- PGPS1_PONAB

UniProt

Q5R8K7 - PGPS1_PONAB

Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Gene

PGS1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.By similarity

    Catalytic activityi

    CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

    Enzyme regulationi

    Activated by calcium and magnesium and inhibited by other bivalent cations.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei220 – 2201PROSITE-ProRule annotation
    Active sitei222 – 2221PROSITE-ProRule annotation
    Active sitei227 – 2271PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi124 – 1318ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phosphatidylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00084; UER00503.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC:2.7.8.5)
    Alternative name(s):
    Phosphatidylglycerophosphate synthase 1
    Short name:
    PGP synthase 1
    Gene namesi
    Name:PGS1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2828MitochondrionSequence AnalysisAdd
    BLAST
    Chaini29 – 556528CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialPRO_0000337108Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R8K7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini215 – 24127PLD phosphodiesterase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini460 – 49334PLD phosphodiesterase 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transit peptide

    Phylogenomic databases

    HOGENOMiHOG000172574.
    HOVERGENiHBG057228.
    InParanoidiQ5R8K7.
    KOiK00995.

    Family and domain databases

    InterProiIPR025202. PLD-like_dom.
    IPR016270. PLipase-D_PtdSer-synthase-type.
    IPR001736. PLipase_D/transphosphatidylase.
    [Graphical view]
    PANTHERiPTHR12586. PTHR12586. 1 hit.
    PfamiPF13091. PLDc_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000850. Phospholipase_D_PSS. 1 hit.
    PROSITEiPS50035. PLD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R8K7-1 [UniParc]FASTAAdd to Basket

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    MAVAAAAAAG PVFWRRLLGL LPGRPGLAAL LGRLSDRLGR NRDRQRRRSP    50
    WLLLAPLLSP AVPQVTSPPC CLCPEGVHRF QWIRNLVPEF GVSSSHVRVL 100
    SSPAESFELM KGQIRVAKRR VVMASLYLGT GPLEQELVDC LESTLEKSLQ 150
    AKFPSNLKVS ILLDFTRGSR GRKNSRTMLL PLPQRFPEQV RVSLFHTPHL 200
    RGLLRLLIPE RFNETIGLQH IKVYLFDNSV ILSGANLSDS YFTNRQDRYV 250
    FLQDCAEIAD FFTELVDAVG DVSLQLQGDD TVQVVDGMVH PYKGDRTEYC 300
    KAANKRVMDV INSARTRQQM LHAQTFHSNS LLTQEDAAAA GDRRPAPDTW 350
    IYPLIQMKPF EIQIDEIVTE TLLTEAERGA KVYLTTGYFN LTQAYMDLVL 400
    GTRAEYQILL ASPEVNGFFG AKGVVGAIPA AYVHIERQFY SEVCSLGQQE 450
    RVQLQEYWRR GWTFHAKGLW LYLAGSSLPC LTLIGSPNFG YRSVHRDLEA 500
    QIAIVTENEA LQQQLHQEQE QLYLRSGVVS SATFEQPSRQ VKLWVKMVTP 550
    LIKNFF 556
    Length:556
    Mass (Da):62,701
    Last modified:December 21, 2004 - v1
    Checksum:i9F49F37C7152AF8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859745 mRNA. Translation: CAH91903.1.
    RefSeqiNP_001126101.1. NM_001132629.1.
    UniGeneiPab.13048.

    Genome annotation databases

    GeneIDi100173056.
    KEGGipon:100173056.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859745 mRNA. Translation: CAH91903.1 .
    RefSeqi NP_001126101.1. NM_001132629.1.
    UniGenei Pab.13048.

    3D structure databases

    ProteinModelPortali Q5R8K7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100173056.
    KEGGi pon:100173056.

    Organism-specific databases

    CTDi 9489.

    Phylogenomic databases

    HOGENOMi HOG000172574.
    HOVERGENi HBG057228.
    InParanoidi Q5R8K7.
    KOi K00995.

    Enzyme and pathway databases

    UniPathwayi UPA00084 ; UER00503 .

    Family and domain databases

    InterProi IPR025202. PLD-like_dom.
    IPR016270. PLipase-D_PtdSer-synthase-type.
    IPR001736. PLipase_D/transphosphatidylase.
    [Graphical view ]
    PANTHERi PTHR12586. PTHR12586. 1 hit.
    Pfami PF13091. PLDc_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000850. Phospholipase_D_PSS. 1 hit.
    PROSITEi PS50035. PLD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiPGPS1_PONAB
    AccessioniPrimary (citable) accession number: Q5R8K7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3