Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Gene

PGS1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.By similarity

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Enzyme regulationi

Activated by calcium and magnesium and inhibited by other bivalent cations.By similarity

Pathway: phosphatidylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (PGS1)
  2. no protein annotated in this organism
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei220 – 2201PROSITE-ProRule annotation
Active sitei222 – 2221PROSITE-ProRule annotation
Active sitei227 – 2271PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi124 – 1318ATPSequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC:2.7.8.5)
Alternative name(s):
Phosphatidylglycerophosphate synthase 1
Short name:
PGP synthase 1
Gene namesi
Name:PGS1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828MitochondrionSequence AnalysisAdd
BLAST
Chaini29 – 556528CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialPRO_0000337108Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000009757.

Structurei

3D structure databases

ProteinModelPortaliQ5R8K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 24127PLD phosphodiesterase 1PROSITE-ProRule annotationAdd
BLAST
Domaini460 – 49334PLD phosphodiesterase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

HOGENOMiHOG000172574.
HOVERGENiHBG057228.
InParanoidiQ5R8K7.
KOiK00995.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR016270. PLipase-D_PtdSer-synthase-type.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PANTHERiPTHR12586. PTHR12586. 1 hit.
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000850. Phospholipase_D_PSS. 1 hit.
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R8K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAAAAAAG PVFWRRLLGL LPGRPGLAAL LGRLSDRLGR NRDRQRRRSP
60 70 80 90 100
WLLLAPLLSP AVPQVTSPPC CLCPEGVHRF QWIRNLVPEF GVSSSHVRVL
110 120 130 140 150
SSPAESFELM KGQIRVAKRR VVMASLYLGT GPLEQELVDC LESTLEKSLQ
160 170 180 190 200
AKFPSNLKVS ILLDFTRGSR GRKNSRTMLL PLPQRFPEQV RVSLFHTPHL
210 220 230 240 250
RGLLRLLIPE RFNETIGLQH IKVYLFDNSV ILSGANLSDS YFTNRQDRYV
260 270 280 290 300
FLQDCAEIAD FFTELVDAVG DVSLQLQGDD TVQVVDGMVH PYKGDRTEYC
310 320 330 340 350
KAANKRVMDV INSARTRQQM LHAQTFHSNS LLTQEDAAAA GDRRPAPDTW
360 370 380 390 400
IYPLIQMKPF EIQIDEIVTE TLLTEAERGA KVYLTTGYFN LTQAYMDLVL
410 420 430 440 450
GTRAEYQILL ASPEVNGFFG AKGVVGAIPA AYVHIERQFY SEVCSLGQQE
460 470 480 490 500
RVQLQEYWRR GWTFHAKGLW LYLAGSSLPC LTLIGSPNFG YRSVHRDLEA
510 520 530 540 550
QIAIVTENEA LQQQLHQEQE QLYLRSGVVS SATFEQPSRQ VKLWVKMVTP

LIKNFF
Length:556
Mass (Da):62,701
Last modified:December 21, 2004 - v1
Checksum:i9F49F37C7152AF8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859745 mRNA. Translation: CAH91903.1.
RefSeqiNP_001126101.1. NM_001132629.1.
UniGeneiPab.13048.

Genome annotation databases

GeneIDi100173056.
KEGGipon:100173056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859745 mRNA. Translation: CAH91903.1.
RefSeqiNP_001126101.1. NM_001132629.1.
UniGeneiPab.13048.

3D structure databases

ProteinModelPortaliQ5R8K7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000009757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100173056.
KEGGipon:100173056.

Organism-specific databases

CTDi9489.

Phylogenomic databases

HOGENOMiHOG000172574.
HOVERGENiHBG057228.
InParanoidiQ5R8K7.
KOiK00995.

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR016270. PLipase-D_PtdSer-synthase-type.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PANTHERiPTHR12586. PTHR12586. 1 hit.
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000850. Phospholipase_D_PSS. 1 hit.
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPGPS1_PONAB
AccessioniPrimary (citable) accession number: Q5R8K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 21, 2004
Last modified: June 24, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.