Reviewed, UniProtKB/Swiss-Prot Q5R8K7 (PGPS1_PONAB)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
    EC=2.7.8.5
Alternative name(s):
    Phosphatidylglycerophosphate synthase 1
      Short name=PGP synthase 1

Gene names

Name:

PGS1

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Enzyme regulation	Activated by calcium and magnesium and inhibited by other bivalent cations By similarity.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-II family. Contains 2 PLD phosphodiesterase domains.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Mitochondrion
Domain	Repeat Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 28	28	Mitochondrion Potential
	Chain	29 – 556	528	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial		PRO_0000337108
Regions
	Domain	215 – 241	27	PLD phosphodiesterase 1
	Domain	460 – 493	34	PLD phosphodiesterase 2
	Nucleotide binding	124 – 131	8	ATP Potential
Sites
	Active site	220	1	Potential
	Active site	222	1	Potential
	Active site	227	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5R8K7-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 9F49F37C7152AF8C	FASTA	556	62,701
	10 20 30 40 50 60 MAVAAAAAAG PVFWRRLLGL LPGRPGLAAL LGRLSDRLGR NRDRQRRRSP WLLLAPLLSP 70 80 90 100 110 120 AVPQVTSPPC CLCPEGVHRF QWIRNLVPEF GVSSSHVRVL SSPAESFELM KGQIRVAKRR 130 140 150 160 170 180 VVMASLYLGT GPLEQELVDC LESTLEKSLQ AKFPSNLKVS ILLDFTRGSR GRKNSRTMLL 190 200 210 220 230 240 PLPQRFPEQV RVSLFHTPHL RGLLRLLIPE RFNETIGLQH IKVYLFDNSV ILSGANLSDS 250 260 270 280 290 300 YFTNRQDRYV FLQDCAEIAD FFTELVDAVG DVSLQLQGDD TVQVVDGMVH PYKGDRTEYC 310 320 330 340 350 360 KAANKRVMDV INSARTRQQM LHAQTFHSNS LLTQEDAAAA GDRRPAPDTW IYPLIQMKPF 370 380 390 400 410 420 EIQIDEIVTE TLLTEAERGA KVYLTTGYFN LTQAYMDLVL GTRAEYQILL ASPEVNGFFG 430 440 450 460 470 480 AKGVVGAIPA AYVHIERQFY SEVCSLGQQE RVQLQEYWRR GWTFHAKGLW LYLAGSSLPC 490 500 510 520 530 540 LTLIGSPNFG YRSVHRDLEA QIAIVTENEA LQQQLHQEQE QLYLRSGVVS SATFEQPSRQ 550 VKLWVKMVTP LIKNFF

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR859745 mRNA. Translation: CAH91903.1.
RefSeq	NP_001126101.1.
UniGene	Pab.13048
3D structure databases
SMR	Q5R8K7. Positions 97-268.
ModBase	Search...
Genome annotation databases
GeneID	100173056.
Organism-specific databases
CTD	100173056.
Phylogenomic databases
HOVERGEN	Q5R8K7.
InParanoid	Q5R8K7.
Family and domain databases
InterPro	IPR016270. PLipase-D_PtdSer-synthase-type. IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
PIRSF	PIRSF000850. Phospholipase_D_PSS. 1 hit.
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGPS1_PONAB

Accession

Primary (citable) accession number: Q5R8K7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	December 21, 2004
Last modified:	January 19, 2010
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)