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Q5R8K7

- PGPS1_PONAB

UniProt

Q5R8K7 - PGPS1_PONAB

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Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Gene

PGS1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.By similarity

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Enzyme regulationi

Activated by calcium and magnesium and inhibited by other bivalent cations.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei220 – 2201PROSITE-ProRule annotation
Active sitei222 – 2221PROSITE-ProRule annotation
Active sitei227 – 2271PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi124 – 1318ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. phosphatidylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC:2.7.8.5)
Alternative name(s):
Phosphatidylglycerophosphate synthase 1
Short name:
PGP synthase 1
Gene namesi
Name:PGS1
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828MitochondrionSequence AnalysisAdd
BLAST
Chaini29 – 556528CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialPRO_0000337108Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5R8K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 24127PLD phosphodiesterase 1PROSITE-ProRule annotationAdd
BLAST
Domaini460 – 49334PLD phosphodiesterase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

HOGENOMiHOG000172574.
HOVERGENiHBG057228.
InParanoidiQ5R8K7.
KOiK00995.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR016270. PLipase-D_PtdSer-synthase-type.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PANTHERiPTHR12586. PTHR12586. 1 hit.
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000850. Phospholipase_D_PSS. 1 hit.
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R8K7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVAAAAAAG PVFWRRLLGL LPGRPGLAAL LGRLSDRLGR NRDRQRRRSP
60 70 80 90 100
WLLLAPLLSP AVPQVTSPPC CLCPEGVHRF QWIRNLVPEF GVSSSHVRVL
110 120 130 140 150
SSPAESFELM KGQIRVAKRR VVMASLYLGT GPLEQELVDC LESTLEKSLQ
160 170 180 190 200
AKFPSNLKVS ILLDFTRGSR GRKNSRTMLL PLPQRFPEQV RVSLFHTPHL
210 220 230 240 250
RGLLRLLIPE RFNETIGLQH IKVYLFDNSV ILSGANLSDS YFTNRQDRYV
260 270 280 290 300
FLQDCAEIAD FFTELVDAVG DVSLQLQGDD TVQVVDGMVH PYKGDRTEYC
310 320 330 340 350
KAANKRVMDV INSARTRQQM LHAQTFHSNS LLTQEDAAAA GDRRPAPDTW
360 370 380 390 400
IYPLIQMKPF EIQIDEIVTE TLLTEAERGA KVYLTTGYFN LTQAYMDLVL
410 420 430 440 450
GTRAEYQILL ASPEVNGFFG AKGVVGAIPA AYVHIERQFY SEVCSLGQQE
460 470 480 490 500
RVQLQEYWRR GWTFHAKGLW LYLAGSSLPC LTLIGSPNFG YRSVHRDLEA
510 520 530 540 550
QIAIVTENEA LQQQLHQEQE QLYLRSGVVS SATFEQPSRQ VKLWVKMVTP

LIKNFF
Length:556
Mass (Da):62,701
Last modified:December 21, 2004 - v1
Checksum:i9F49F37C7152AF8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859745 mRNA. Translation: CAH91903.1.
RefSeqiNP_001126101.1. NM_001132629.1.
UniGeneiPab.13048.

Genome annotation databases

GeneIDi100173056.
KEGGipon:100173056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859745 mRNA. Translation: CAH91903.1 .
RefSeqi NP_001126101.1. NM_001132629.1.
UniGenei Pab.13048.

3D structure databases

ProteinModelPortali Q5R8K7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100173056.
KEGGi pon:100173056.

Organism-specific databases

CTDi 9489.

Phylogenomic databases

HOGENOMi HOG000172574.
HOVERGENi HBG057228.
InParanoidi Q5R8K7.
KOi K00995.

Enzyme and pathway databases

UniPathwayi UPA00084 ; UER00503 .

Family and domain databases

InterProi IPR025202. PLD-like_dom.
IPR016270. PLipase-D_PtdSer-synthase-type.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view ]
PANTHERi PTHR12586. PTHR12586. 1 hit.
Pfami PF13091. PLDc_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000850. Phospholipase_D_PSS. 1 hit.
PROSITEi PS50035. PLD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPGPS1_PONAB
AccessioniPrimary (citable) accession number: Q5R8K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3