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Q5R8I8 (PISD_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:PISD
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.

Cofactor

Pyruvoyl group By similarity.

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.

Subunit structure

Heterodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentMitochondrion
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionphosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Phosphatidylserine decarboxylase beta chain
PRO_0000029839
Chain378 – 40932Phosphatidylserine decarboxylase alpha chain
PRO_0000029840

Sites

Site377 – 3782Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue3781Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R8I8 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: CE69C5D344644FE3

FASTA40946,601
        10         20         30         40         50         60 
MATSVGHRCL GLLHGVAPWR SSLHPCEITA LSQSLQPLRK LPFRAFRTDA RKIHTAPART 

        70         80         90        100        110        120 
MFLLRPVPIL LATGGGYAGY RQYEKYRERE LEKLGLEIPP KLAGHWEVAL YKSVPTRLLS 

       130        140        150        160        170        180 
RAWGRLNQVE LPHWLRRPVY SLYIWTFGVN MKEAAVEDLH HYRNLSEFFR RKLKPQARPV 

       190        200        210        220        230        240 
CGLHSVISPS DGRILNFGQV KNCEVEQVKG VTYSLESFLG PRTCTEDLPF PPATSCDSFK 

       250        260        270        280        290        300 
NQLVTREGNE LYHCVIYLAP GDYHCFHSPT DWTVSHRRHF PGSLMSVNPG MARWIKELFC 

       310        320        330        340        350        360 
HNERVVLTGD WKHGFFSLTA VGATNVGSIR IYFDQDLHTN SPRHSKGSYN DFSFVTHTNR 

       370        380        390        400 
EGVPMRKGEH LGEFNLGSTI VLIFEAPKDF NFQLKTGQKI RFGEALGSL

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR859764 mRNA. Translation: CAH91922.1.
RefSeqNP_001126113.1. NM_001132641.1.
UniGenePab.12977.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPPYT00000013627; ENSPPYP00000013093; ENSPPYG00000011738.
GeneID100173069.
KEGGpon:100173069.

Organism-specific databases

CTD23761.

Phylogenomic databases

HOVERGENHBG039630.
InParanoidQ5R8I8.
OMAMCQSEAR.
OrthoDBEOG441QC2.

Family and domain databases

InterProIPR003817. PS_Dcarbxylase.
IPR005221. PS_decarb.
[Graphical view]
KOK01613.
PANTHERPTHR10067. PS_decarb. 1 hit.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00163. PS_decarb. 1 hit.
ProtoNetSearch...

Entry information

Entry namePISD_PONAB
AccessionPrimary (citable) accession number: Q5R8I8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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