Q5R8I8 (PISD_PONAB) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 38.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphatidylserine decarboxylase proenzyme EC=4.1.1.65 Cleaved into the following 2 chains: | ||
| Gene names |
| ||
| Organism | Pongo abelii (Sumatran orangutan) | ||
| Taxonomic identifier | 9601 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo |
Protein attributes
| Sequence length | 409 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Catalytic activity | Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. |
| Cofactor | Pyruvoyl group By similarity. |
| Pathway | |
| Subunit structure | Heterodimer By similarity. |
| Subcellular location | Mitochondrion By similarity. |
| Sequence similarities | Belongs to the phosphatidylserine decarboxylase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phospholipid biosynthesis |
| Cellular component | Mitochondrion |
| Ligand | Pyruvate |
| Molecular function | Decarboxylase Lyase |
| PTM | Zymogen |
| Gene Ontology (GO) | |
| Biological process | phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 377 | 377 | Phosphatidylserine decarboxylase beta chain | PRO_0000029839 | |||||
| Chain | 378 – 409 | 32 | Phosphatidylserine decarboxylase alpha chain | PRO_0000029840 | |||||
Sites | |||||||||
| Site | 377 – 378 | 2 | Cleavage (non-hydrolytic) By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 378 | 1 | Pyruvic acid (Ser) By similarity | ||||||
Sequences
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References
| [1] | The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR859764 mRNA. Translation: CAH91922.1. |
| RefSeq | NP_001126113.1. NM_001132641.1. |
| UniGene | Pab.12977. |
3D structure databases | |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSPPYT00000013627; ENSPPYP00000013093; ENSPPYG00000011738. |
| GeneID | 100173069. |
| KEGG | pon:100173069. |
Organism-specific databases | |
| CTD | 23761. |
Phylogenomic databases | |
| HOVERGEN | HBG039630. |
| InParanoid | Q5R8I8. |
| OMA | MCQSEAR. |
| OrthoDB | EOG441QC2. |
Family and domain databases | |
| InterPro | IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view] |
| KO | K01613. |
| PANTHER | PTHR10067. PS_decarb. 1 hit. |
| Pfam | PF02666. PS_Dcarbxylase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00163. PS_decarb. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PISD_PONAB | ||||||||
| Accession | Primary (citable) accession number: Q5R8I8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with