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Q5R8C0

- PPA6_PONAB

UniProt

Q5R8C0 - PPA6_PONAB

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Protein
Lysophosphatidic acid phosphatase type 6
Gene
ACP6
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid By similarity.

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei59 – 591Nucleophile By similarity
Active sitei335 – 3351Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. lysophosphatidic acid phosphatase activity Source: UniProtKB

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. lysobisphosphatidic acid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid phosphatase type 6 (EC:3.1.3.2)
Alternative name(s):
Acid phosphatase 6, lysophosphatidic
Gene namesi
Name:ACP6
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Unplaced

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232Mitochondrion By similarity
Add
BLAST
Chaini33 – 428396Lysophosphatidic acid phosphatase type 6
PRO_0000023967Add
BLAST

Proteomic databases

PRIDEiQ5R8C0.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5R8C0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 168111Substrate binding By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG079458.
InParanoidiQ5R8C0.
KOiK14395.

Family and domain databases

Gene3Di3.40.50.1240. 2 hits.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R8C0-1 [UniParc]FASTAAdd to Basket

« Hide

MITGVFSMRL WTPVGVLTSL AYCLHQRRVA LAELQEADGR RPVDRSLLKS    50
KMVQVVFRHG ARSPRKPLPL EEQVEWNPQL LEVPPQTQFD YTVTNLAGGP 100
KPYSPYDAQY CETTLKGGMF AGQLTKVGMQ QMFALGERLR KNYVEDIPFL 150
SPTFSPQEVF IRSTNIFRNL ESTRCLLAGL FQCQKEGPII IHTDEADSEV 200
LYPNYQSCWS LRQRTRGRRQ TASLQPGISE DLKKVKDRMG IDSSDKVDFF 250
ILLDNMAAEQ AHNLPSCPML KRFAQMIEQR AVDTSLYILP KEDRESLQMA 300
VGPLLHILES NLLKAMDSAT APDKIRKLYL YAAHDVTLIP LLMTLGIFDH 350
KWPPFAVDLT MELYQHLESK EWFVQLYYHG KEQVPRGCPD GLCPLDMFLN 400
AMSVYTLSPE KYHALCSQTQ VMEVGNGE 428
Length:428
Mass (Da):48,771
Last modified:December 21, 2004 - v1
Checksum:i76F75BB45A6C46B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859833 mRNA. Translation: CAH91990.1.
RefSeqiNP_001127492.1. NM_001134020.1.
UniGeneiPab.13072.

Genome annotation databases

GeneIDi100174567.
KEGGipon:100174567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR859833 mRNA. Translation: CAH91990.1 .
RefSeqi NP_001127492.1. NM_001134020.1.
UniGenei Pab.13072.

3D structure databases

ProteinModelPortali Q5R8C0.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5R8C0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100174567.
KEGGi pon:100174567.

Organism-specific databases

CTDi 51205.

Phylogenomic databases

HOVERGENi HBG079458.
InParanoidi Q5R8C0.
KOi K14395.

Family and domain databases

Gene3Di 3.40.50.1240. 2 hits.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 2 hits.
ProtoNeti Search...

Publicationsi

  1. The German cDNA consortium
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPPA6_PONAB
AccessioniPrimary (citable) accession number: Q5R8C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi