Reviewed, UniProtKB/Swiss-Prot Q5R8C0 (PPA6_PONAB)

Names and origin

Protein names

Recommended name:
    Lysophosphatidic acid phosphatase type 6
    EC=3.1.3.2
Alternative name(s):
    Acid phosphatase 6, lysophosphatidic

Gene names

Name:

ACP6

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolyzes lysophosphatidic acid to monoacylglycerol By similarity.
Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the histidine acid phosphatase family.
Caution	It is uncertain whether Met-1 or Met-8 is the initiator.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	By similarity
	Chain	33 – 428	396	Lysophosphatidic acid phosphatase type 6		PRO_0000023967
Sites
	Active site	59	1	Nucleophile By similarity
	Active site	335	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R8C0-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 76F75BB45A6C46B0	FASTA	428	48,771
	10 20 30 40 50 60 MITGVFSMRL WTPVGVLTSL AYCLHQRRVA LAELQEADGR RPVDRSLLKS KMVQVVFRHG 70 80 90 100 110 120 ARSPRKPLPL EEQVEWNPQL LEVPPQTQFD YTVTNLAGGP KPYSPYDAQY CETTLKGGMF 130 140 150 160 170 180 AGQLTKVGMQ QMFALGERLR KNYVEDIPFL SPTFSPQEVF IRSTNIFRNL ESTRCLLAGL 190 200 210 220 230 240 FQCQKEGPII IHTDEADSEV LYPNYQSCWS LRQRTRGRRQ TASLQPGISE DLKKVKDRMG 250 260 270 280 290 300 IDSSDKVDFF ILLDNMAAEQ AHNLPSCPML KRFAQMIEQR AVDTSLYILP KEDRESLQMA 310 320 330 340 350 360 VGPLLHILES NLLKAMDSAT APDKIRKLYL YAAHDVTLIP LLMTLGIFDH KWPPFAVDLT 370 380 390 400 410 420 MELYQHLESK EWFVQLYYHG KEQVPRGCPD GLCPLDMFLN AMSVYTLSPE KYHALCSQTQ VMEVGNGE

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR859833 mRNA. Translation: CAH91990.1.
RefSeq	NP_001127492.1.
UniGene	Pab.13072
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100174567.
Organism-specific databases
CTD	100174567.
Phylogenomic databases
HOVERGEN	Q5R8C0.
InParanoid	Q5R8C0.
Enzyme and pathway databases
BRENDA	3.1.3.2. 269192.
Family and domain databases
InterPro	IPR000560. Histidine_acid_Pase. [Graphical view]
Pfam	PF00328. Acid_phosphat_A. 1 hit. [Graphical view]
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. False negative. PS00778. HIS_ACID_PHOSPHAT_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPA6_PONAB

Accession

Primary (citable) accession number: Q5R8C0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	December 21, 2004
Last modified:	December 15, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)