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Q5R8C0 (PPA6_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophosphatidic acid phosphatase type 6

EC=3.1.3.2
Alternative name(s):
Acid phosphatase 6, lysophosphatidic
Gene names
Name:ACP6
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid By similarity.

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subunit structure

Monomer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3232Mitochondrion By similarity
Chain33 – 428396Lysophosphatidic acid phosphatase type 6
PRO_0000023967

Regions

Region58 – 168111Substrate binding By similarity

Sites

Active site591Nucleophile By similarity
Active site3351Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5R8C0 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 76F75BB45A6C46B0

FASTA42848,771
        10         20         30         40         50         60 
MITGVFSMRL WTPVGVLTSL AYCLHQRRVA LAELQEADGR RPVDRSLLKS KMVQVVFRHG 

        70         80         90        100        110        120 
ARSPRKPLPL EEQVEWNPQL LEVPPQTQFD YTVTNLAGGP KPYSPYDAQY CETTLKGGMF 

       130        140        150        160        170        180 
AGQLTKVGMQ QMFALGERLR KNYVEDIPFL SPTFSPQEVF IRSTNIFRNL ESTRCLLAGL 

       190        200        210        220        230        240 
FQCQKEGPII IHTDEADSEV LYPNYQSCWS LRQRTRGRRQ TASLQPGISE DLKKVKDRMG 

       250        260        270        280        290        300 
IDSSDKVDFF ILLDNMAAEQ AHNLPSCPML KRFAQMIEQR AVDTSLYILP KEDRESLQMA 

       310        320        330        340        350        360 
VGPLLHILES NLLKAMDSAT APDKIRKLYL YAAHDVTLIP LLMTLGIFDH KWPPFAVDLT 

       370        380        390        400        410        420 
MELYQHLESK EWFVQLYYHG KEQVPRGCPD GLCPLDMFLN AMSVYTLSPE KYHALCSQTQ 


VMEVGNGE 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR859833 mRNA. Translation: CAH91990.1.
RefSeqNP_001127492.1. NM_001134020.1.
UniGenePab.13072.

3D structure databases

ProteinModelPortalQ5R8C0.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5R8C0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100174567.
KEGGpon:100174567.

Organism-specific databases

CTD51205.

Phylogenomic databases

HOVERGENHBG079458.
InParanoidQ5R8C0.
KOK14395.

Family and domain databases

InterProIPR000560. His_Pase_superF_clade-2.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPA6_PONAB
AccessionPrimary (citable) accession number: Q5R8C0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families