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Q5R8C0

- PPA6_PONAB

UniProt

Q5R8C0 - PPA6_PONAB

Protein

Lysophosphatidic acid phosphatase type 6

Gene

ACP6

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid By similarity.By similarity

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei59 – 591NucleophileBy similarity
    Active sitei335 – 3351Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. lysophosphatidic acid phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. dephosphorylation Source: GOC
    2. lysobisphosphatidic acid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid metabolism, Phospholipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophosphatidic acid phosphatase type 6 (EC:3.1.3.2)
    Alternative name(s):
    Acid phosphatase 6, lysophosphatidic
    Gene namesi
    Name:ACP6
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3232MitochondrionBy similarityAdd
    BLAST
    Chaini33 – 428396Lysophosphatidic acid phosphatase type 6PRO_0000023967Add
    BLAST

    Proteomic databases

    PRIDEiQ5R8C0.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R8C0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 168111Substrate bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG079458.
    InParanoidiQ5R8C0.
    KOiK14395.

    Family and domain databases

    Gene3Di3.40.50.1240. 2 hits.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R8C0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITGVFSMRL WTPVGVLTSL AYCLHQRRVA LAELQEADGR RPVDRSLLKS    50
    KMVQVVFRHG ARSPRKPLPL EEQVEWNPQL LEVPPQTQFD YTVTNLAGGP 100
    KPYSPYDAQY CETTLKGGMF AGQLTKVGMQ QMFALGERLR KNYVEDIPFL 150
    SPTFSPQEVF IRSTNIFRNL ESTRCLLAGL FQCQKEGPII IHTDEADSEV 200
    LYPNYQSCWS LRQRTRGRRQ TASLQPGISE DLKKVKDRMG IDSSDKVDFF 250
    ILLDNMAAEQ AHNLPSCPML KRFAQMIEQR AVDTSLYILP KEDRESLQMA 300
    VGPLLHILES NLLKAMDSAT APDKIRKLYL YAAHDVTLIP LLMTLGIFDH 350
    KWPPFAVDLT MELYQHLESK EWFVQLYYHG KEQVPRGCPD GLCPLDMFLN 400
    AMSVYTLSPE KYHALCSQTQ VMEVGNGE 428
    Length:428
    Mass (Da):48,771
    Last modified:December 21, 2004 - v1
    Checksum:i76F75BB45A6C46B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859833 mRNA. Translation: CAH91990.1.
    RefSeqiNP_001127492.1. NM_001134020.1.
    UniGeneiPab.13072.

    Genome annotation databases

    GeneIDi100174567.
    KEGGipon:100174567.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859833 mRNA. Translation: CAH91990.1 .
    RefSeqi NP_001127492.1. NM_001134020.1.
    UniGenei Pab.13072.

    3D structure databases

    ProteinModelPortali Q5R8C0.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5R8C0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100174567.
    KEGGi pon:100174567.

    Organism-specific databases

    CTDi 51205.

    Phylogenomic databases

    HOVERGENi HBG079458.
    InParanoidi Q5R8C0.
    KOi K14395.

    Family and domain databases

    Gene3Di 3.40.50.1240. 2 hits.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiPPA6_PONAB
    AccessioniPrimary (citable) accession number: Q5R8C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-8 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3