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Reviewed, UniProtKB/Swiss-Prot Q5R890 (MINP1_PONAB)

Last modified June 16, 2009. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesRecommended name:
    Multiple inositol polyphosphate phosphatase 1
    EC=3.1.3.62
Alternative name(s):
    Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
    Ins(1,3,4,5)P(4) 3-phosphatase
Gene names
Name: MINPP1
OrganismPongo abelii (Sumatran orangutan)
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

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Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) By similarity. May play a role in bone development (endochondral ossification) By similarity.

Catalytic activity

Myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.

Subcellular location

Endoplasmic reticulum lumen By similarity.

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Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Cellular componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-KW

endoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacid phosphatase activity

Inferred from electronic annotation. Source: InterPro

multiple inositol-polyphosphate phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 487457Multiple inositol polyphosphate phosphatase 1
PRO_0000019584

Regions

Motif484 – 4874Prevents secretion from ER Potential

Sites

Active site891 Potential

Amino acid modifications

Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation4811N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q5R890-1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: F95A1B12B4EA1660

FASTA48755,090
        10         20         30         40         50         60 
MLRASGCLLR TSVAPAAALA AALFSSLARC SLLEPRDLVA SSLSPYFGTK TRYEDVNPLL 

        70         80         90        100        110        120 
LSGPEAPWRD PELLEGSCTP VQLVALIRHG TRYPTAKQIR KLRQLHGLLQ ARGSRDGGAG 

       130        140        150        160        170        180 
STGSRDLGAA LADWPLWYAD WMDGQLVEKG RQDMRQLALR LASLFPALFS RENYGRLRLI 

       190        200        210        220        230        240 
TSSKHRCMDS SAAFLQGLWQ HYHPGLPPPD VADMEFGPPT VNDKLMRFFD HCEKFLTEVE 

       250        260        270        280        290        300 
KNATALYHVE AFKTGPEMQN ILKKVAATLQ VPVNDLNADL LQVAFFTCSF DLAIKGVKSP 

       310        320        330        340        350        360 
WCDVFDIDDA KVLEYLNDLK QYWKRGYGYT INSRSSCTLF QDIFRHLDKA VEQKQRSQPI 

       370        380        390        400        410        420 
SSPVILQFGH AETLLPLLSL MGYFKDKEPL TAYNYKEQMH RKFRSGLIVP YASNLIFVLY 

       430        440        450        460        470        480 
HCENAKTPKE QFRVQMLLNE KVLPLAYSQE TVSFYEDLRN HYKDILQSCQ TSEECELARA 


NSTSDEL

« Hide

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References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

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Cross-references

Sequence databases

CR859864 mRNA. Translation: CAH92020.1.
RefSeqNP_001126173.1.
UniGenePab.11388

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID100173135.

Phylogenomic databases

HOVERGENQ5R890.

Enzyme and pathway databases

BRENDA3.1.3.62. 269192.

Family and domain databases

InterProIPR000886. ER_targeting_sequence.
IPR000560. Histidine_acid_Pase.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamPF00328. Acid_phosphat_A. 1 hit.
[Graphical view]
PIRSFPIRSF000894. Acid_phosphatase. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMINP1_PONAB
AccessionPrimary (citable) accession number: Q5R890
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information