Q5R890 (MINP1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Multiple inositol polyphosphate phosphatase 1
EC=3.1.3.62

Alternative name(s):
2,3-bisphosphoglycerate 3-phosphatase
Short name=2,3-BPG phosphatase
EC=3.1.3.80
Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
Short name=Ins(1,3,4,5)P(4) 3-phosphatase

Gene names

Name:

MINPP1

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification) By similarity.
Catalytic activity	Myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate. 2,3-bisphospho-D-glycerate + H2O = 2-phospho-D-glycerate + phosphate.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acid phosphatase activity Inferred from electronic annotation. Source: InterPro bisphosphoglycerate 3-phosphatase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 2-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 487	457	Multiple inositol polyphosphate phosphatase 1		PRO_0000019584
Regions
	Motif	484 – 487	4	Prevents secretion from ER Potential
Sites
	Active site	89	1	Potential
Amino acid modifications
	Glycosylation	242	1	N-linked (GlcNAc...) Potential
	Glycosylation	481	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5R890 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: F95A1B12B4EA1660	FASTA	487	55,090
	10 20 30 40 50 60 MLRASGCLLR TSVAPAAALA AALFSSLARC SLLEPRDLVA SSLSPYFGTK TRYEDVNPLL 70 80 90 100 110 120 LSGPEAPWRD PELLEGSCTP VQLVALIRHG TRYPTAKQIR KLRQLHGLLQ ARGSRDGGAG 130 140 150 160 170 180 STGSRDLGAA LADWPLWYAD WMDGQLVEKG RQDMRQLALR LASLFPALFS RENYGRLRLI 190 200 210 220 230 240 TSSKHRCMDS SAAFLQGLWQ HYHPGLPPPD VADMEFGPPT VNDKLMRFFD HCEKFLTEVE 250 260 270 280 290 300 KNATALYHVE AFKTGPEMQN ILKKVAATLQ VPVNDLNADL LQVAFFTCSF DLAIKGVKSP 310 320 330 340 350 360 WCDVFDIDDA KVLEYLNDLK QYWKRGYGYT INSRSSCTLF QDIFRHLDKA VEQKQRSQPI 370 380 390 400 410 420 SSPVILQFGH AETLLPLLSL MGYFKDKEPL TAYNYKEQMH RKFRSGLIVP YASNLIFVLY 430 440 450 460 470 480 HCENAKTPKE QFRVQMLLNE KVLPLAYSQE TVSFYEDLRN HYKDILQSCQ TSEECELARA NSTSDEL

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR859864 mRNA. Translation: CAH92020.1.
RefSeq	NP_001126173.1. NM_001132701.1.
UniGene	Pab.11388.
3D structure databases
ProteinModelPortal	Q5R890.
ModBase	Search...
Proteomic databases
PRIDE	Q5R890.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100173135.
KEGG	pon:100173135.
Organism-specific databases
CTD	9562.
Phylogenomic databases
HOVERGEN	HBG052872.
InParanoid	Q5R890.
KO	K03103.
Family and domain databases
InterPro	IPR000560. His_Pase_superF_clade-2. IPR016274. Histidine_acid_Pase_euk. [Graphical view]
Pfam	PF00328. His_Phos_2. 1 hit. [Graphical view]
PIRSF	PIRSF000894. Acid_phosphatase. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MINP1_PONAB

Accession

Primary (citable) accession number: Q5R890

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	December 21, 2004
Last modified:	October 3, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program