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Q5R890

- MINP1_PONAB

UniProt

Q5R890 - MINP1_PONAB

Protein

Multiple inositol polyphosphate phosphatase 1

Gene

MINPP1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification) By similarity.By similarity

    Catalytic activityi

    Myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.
    2,3-bisphospho-D-glycerate + H2O = 2-phospho-D-glycerate + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Sequence Analysis

    GO - Molecular functioni

    1. acid phosphatase activity Source: InterPro
    2. bisphosphoglycerate 3-phosphatase activity Source: UniProtKB-EC
    3. inositol hexakisphosphate 2-phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multiple inositol polyphosphate phosphatase 1 (EC:3.1.3.62)
    Alternative name(s):
    2,3-bisphosphoglycerate 3-phosphatase (EC:3.1.3.80)
    Short name:
    2,3-BPG phosphatase
    Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
    Short name:
    Ins(1,3,4,5)P(4) 3-phosphatase
    Gene namesi
    Name:MINPP1
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Unplaced

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 487457Multiple inositol polyphosphate phosphatase 1PRO_0000019584Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ5R890.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5R890.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi484 – 4874Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG052872.
    InParanoidiQ5R890.
    KOiK03103.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    IPR016274. Histidine_acid_Pase_euk.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5R890-1 [UniParc]FASTAAdd to Basket

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    MLRASGCLLR TSVAPAAALA AALFSSLARC SLLEPRDLVA SSLSPYFGTK    50
    TRYEDVNPLL LSGPEAPWRD PELLEGSCTP VQLVALIRHG TRYPTAKQIR 100
    KLRQLHGLLQ ARGSRDGGAG STGSRDLGAA LADWPLWYAD WMDGQLVEKG 150
    RQDMRQLALR LASLFPALFS RENYGRLRLI TSSKHRCMDS SAAFLQGLWQ 200
    HYHPGLPPPD VADMEFGPPT VNDKLMRFFD HCEKFLTEVE KNATALYHVE 250
    AFKTGPEMQN ILKKVAATLQ VPVNDLNADL LQVAFFTCSF DLAIKGVKSP 300
    WCDVFDIDDA KVLEYLNDLK QYWKRGYGYT INSRSSCTLF QDIFRHLDKA 350
    VEQKQRSQPI SSPVILQFGH AETLLPLLSL MGYFKDKEPL TAYNYKEQMH 400
    RKFRSGLIVP YASNLIFVLY HCENAKTPKE QFRVQMLLNE KVLPLAYSQE 450
    TVSFYEDLRN HYKDILQSCQ TSEECELARA NSTSDEL 487
    Length:487
    Mass (Da):55,090
    Last modified:December 21, 2004 - v1
    Checksum:iF95A1B12B4EA1660
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859864 mRNA. Translation: CAH92020.1.
    RefSeqiNP_001126173.1. NM_001132701.1.
    UniGeneiPab.11388.

    Genome annotation databases

    GeneIDi100173135.
    KEGGipon:100173135.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR859864 mRNA. Translation: CAH92020.1 .
    RefSeqi NP_001126173.1. NM_001132701.1.
    UniGenei Pab.11388.

    3D structure databases

    ProteinModelPortali Q5R890.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5R890.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100173135.
    KEGGi pon:100173135.

    Organism-specific databases

    CTDi 9562.

    Phylogenomic databases

    HOVERGENi HBG052872.
    InParanoidi Q5R890.
    KOi K03103.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    IPR016274. Histidine_acid_Pase_euk.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. The German cDNA consortium
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiMINP1_PONAB
    AccessioniPrimary (citable) accession number: Q5R890
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3