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Q5R890 (MINP1_PONAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multiple inositol polyphosphate phosphatase 1

EC=3.1.3.62
Alternative name(s):
2,3-bisphosphoglycerate 3-phosphatase
Short name=2,3-BPG phosphatase
EC=3.1.3.80
Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
Short name=Ins(1,3,4,5)P(4) 3-phosphatase
Gene names
Name:MINPP1
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]
Taxonomic identifier9601 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification) By similarity.

Catalytic activity

Myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.

2,3-bisphospho-D-glycerate + H2O = 2-phospho-D-glycerate + phosphate.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 487457Multiple inositol polyphosphate phosphatase 1
PRO_0000019584

Regions

Motif484 – 4874Prevents secretion from ER Potential

Sites

Active site891 Potential

Amino acid modifications

Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation4811N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5R890 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: F95A1B12B4EA1660

FASTA48755,090
        10         20         30         40         50         60 
MLRASGCLLR TSVAPAAALA AALFSSLARC SLLEPRDLVA SSLSPYFGTK TRYEDVNPLL 

        70         80         90        100        110        120 
LSGPEAPWRD PELLEGSCTP VQLVALIRHG TRYPTAKQIR KLRQLHGLLQ ARGSRDGGAG 

       130        140        150        160        170        180 
STGSRDLGAA LADWPLWYAD WMDGQLVEKG RQDMRQLALR LASLFPALFS RENYGRLRLI 

       190        200        210        220        230        240 
TSSKHRCMDS SAAFLQGLWQ HYHPGLPPPD VADMEFGPPT VNDKLMRFFD HCEKFLTEVE 

       250        260        270        280        290        300 
KNATALYHVE AFKTGPEMQN ILKKVAATLQ VPVNDLNADL LQVAFFTCSF DLAIKGVKSP 

       310        320        330        340        350        360 
WCDVFDIDDA KVLEYLNDLK QYWKRGYGYT INSRSSCTLF QDIFRHLDKA VEQKQRSQPI 

       370        380        390        400        410        420 
SSPVILQFGH AETLLPLLSL MGYFKDKEPL TAYNYKEQMH RKFRSGLIVP YASNLIFVLY 

       430        440        450        460        470        480 
HCENAKTPKE QFRVQMLLNE KVLPLAYSQE TVSFYEDLRN HYKDILQSCQ TSEECELARA 


NSTSDEL 

« Hide

References

[1]The German cDNA consortium
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR859864 mRNA. Translation: CAH92020.1.
RefSeqNP_001126173.1. NM_001132701.1.
UniGenePab.11388.

3D structure databases

ProteinModelPortalQ5R890.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5R890.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100173135.
KEGGpon:100173135.

Organism-specific databases

CTD9562.

Phylogenomic databases

HOVERGENHBG052872.
InParanoidQ5R890.
KOK03103.

Family and domain databases

InterProIPR000560. His_Pase_superF_clade-2.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFPIRSF000894. Acid_phosphatase. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMINP1_PONAB
AccessionPrimary (citable) accession number: Q5R890
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families