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Protein

Putative adenosylhomocysteinase 3

Gene

AHCYL2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg2+-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate.By similarity

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD+By similarityNote: Binds 1 NAD+ per subunit.By similarity

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (AHCY), Putative adenosylhomocysteinase 3 (AHCYL2), Adenosylhomocysteinase (AHCYL1), Adenosylhomocysteinase (AHCYL2)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133SubstrateBy similarity1
Binding sitei207SubstrateBy similarity1
Binding sitei232SubstrateBy similarity1
Binding sitei262SubstrateBy similarity1
Binding sitei266SubstrateBy similarity1
Binding sitei267NADBy similarity1
Binding sitei319NADBy similarity1
Binding sitei354NADBy similarity1
Binding sitei422NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi233 – 235NADBy similarity3
Nucleotide bindingi298 – 303NADBy similarity6
Nucleotide bindingi375 – 377NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenosylhomocysteinase 3 (EC:3.3.1.1)
Short name:
AdoHcyase 3
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase 3
S-adenosylhomocysteine hydrolase-like protein 2
Gene namesi
Name:AHCYL2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002303021 – 508Putative adenosylhomocysteinase 3Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei369PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5R889.

Interactioni

Subunit structurei

Homotetramer. Forms heteromultimers with AHCYL1 (via the C-terminal region). Interacts with ITPR1; with lower affinity than AHCYL1 and maybe via ITPR1. Interacts with SLC4A4.By similarity

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000020187.

Structurei

3D structure databases

ProteinModelPortaliQ5R889.
SMRiQ5R889.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.Curated

Phylogenomic databases

eggNOGiKOG1370. Eukaryota.
COG0499. LUCA.
HOVERGENiHBG005041.
InParanoidiQ5R889.
KOiK01251.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
InterProiView protein in InterPro
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5R889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSKKKYIV NGNSGIKAQI QFADQKQEFN KRPTKIGRRS LSRSISQSST
60 70 80 90 100
DSYSSAASYT DSSDDETSPR DKQQKNSKGS SDFCVKNIKQ AEFGRREIEI
110 120 130 140 150
AEQEMPALMA LRKRAQGEKP LAGAKIVGCT HITAQTAVLM ETLGALGAQC
160 170 180 190 200
RWAACNIYST LNEVAAALAE SGFPVFAWKG ESEDDFWWCI DRCVNVEGWQ
210 220 230 240 250
PNMILDDGGD LTHWIYKKYP NMFKKIKGIV EESVTGVHRL YQLSKAGKLC
260 270 280 290 300
VPAMNVNDSV TKQKFDNLYC CRESILDGLK RTTDMMFGGK QVVVCGYGEV
310 320 330 340 350
GKGCCAALKA MGSIVYVTEI DPICALQACM DGFRLVKLNE VIRQVDIVIT
360 370 380 390 400
CTGNKNVVTR EHLDRMKNSC IVCNIGHSNT EIDVASLRTP ELTWERVRSQ
410 420 430 440 450
VDHVIWPDGK RIVLLAEGRL LNLSCSTVPT FVLSITATTQ ALALIELYNA
460 470 480 490 500
PEGRYKQDVY LLPKKMDEYV ASLHLPTFDA HLTELTDEQA KYLGLNKNGP

FKPNYYRY
Length:508
Mass (Da):56,679
Last modified:December 21, 2004 - v1
Checksum:iA59869443CC8F707
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859865 mRNA. Translation: CAH92021.1.
RefSeqiNP_001126174.1. NM_001132702.1.
UniGeneiPab.9439.

Genome annotation databases

GeneIDi100173136.
KEGGipon:100173136.

Similar proteinsi

Entry informationi

Entry nameiSAHH3_PONAB
AccessioniPrimary (citable) accession number: Q5R889
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families