Reviewed, UniProtKB/Swiss-Prot Q5R875 (TMX3_PONAB)

Names and origin

Protein names

Recommended name:
    Protein disulfide-isomerase TMX3
    EC=5.3.4.1
Alternative name(s):
    Thioredoxin-related transmembrane protein 3
    Thioredoxin domain-containing protein 10

Gene names

Name:	TMX3
Synonyms:	TXNDC10

Organism

Pongo abelii (Sumatran orangutan)

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase By similarity.
Catalytic activity	Catalyzes the rearrangement of -S-S- bonds in proteins.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.
Domain	The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins By similarity.
Post-translational modification	N-glycosylated By similarity.
Sequence similarities	Belongs to the protein disulfide isomerase family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Redox-active center Signal Transmembrane
Molecular function	Isomerase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein disulfide isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 454	430	Protein disulfide-isomerase TMX3		PRO_0000034187
Regions
	Topological domain	25 – 375	351	Lumenal Potential
	Transmembrane	376 – 396	21	Potential
	Topological domain	397 – 454	58	Cytoplasmic Potential
	Domain	25 – 128	104	Thioredoxin
	Motif	451 – 454	4	Di-lysine motif
Amino acid modifications
	Modified residue	268	1	Phosphoserine By similarity
	Glycosylation	258	1	N-linked (GlcNAc...) Potential
	Glycosylation	313	1	N-linked (GlcNAc...) Potential
	Disulfide bond	53 ↔ 56		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5R875-1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 174103DD6A9FBE5A	FASTA	454	51,844
	10 20 30 40 50 60 MAAWKSWAAL RLCATVVLLD MVVCKGFVED LDESFKENRN DDIWLVDFYA PWCGHCKKLE 70 80 90 100 110 120 PIWNEVGLEM KSIGSPVKVG KMDATSYSSI ASEFGVRGYP TIKLLKGDLA YNHRGPRTKD 130 140 150 160 170 180 DIIEFAHRVS GALIRPLPSQ QMFEHMQKRH RVFFVYIGGE SPLKEKYIDA ASELIVYTYF 190 200 210 220 230 240 FSASEEVVPE YVTLKEMPAV LVFKDETYFV YDEYEDGDLS SWINRERFQN YLAMDGFLLY 250 260 270 280 290 300 ELGDTGKLVA LAVIDEKNTS VEHTRLKSII QEVARDYRDL FHRDFQFGHM DGNDYINTLL 310 320 330 340 350 360 MDELTVPTVV VLNTSNQQYF LLDRQIKNVE DMVQFINNIL DGTVEAQGGD SILQRLKRIV 370 380 390 400 410 420 FDAKSTIVSI FKSSPLMGCF LFGLPLGVIS IMCYGIYTAD TDGGYIEERY EVSKSENENQ 430 440 450 EQIEESKEQQ EPSSGGSVVP TVQEPKDVLE KKKD

References

[1]	The German cDNA consortium Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR859879 mRNA. Translation: CAH92035.1.
RefSeq	NP_001126183.1.
UniGene	Pab.11571
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100173147.
Organism-specific databases
CTD	100173147.
Phylogenomic databases
HOVERGEN	Q5R875.
Enzyme and pathway databases
BRENDA	5.3.4.1. 269192.
Family and domain databases
InterPro	IPR017936. Thioredoxin-like. IPR006662. Thioredoxin-like_subdom. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00085. Thioredoxin. 1 hit. [Graphical view]
PRINTS	PR00421. THIOREDOXIN.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TMX3_PONAB

Accession

Primary (citable) accession number: Q5R875

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	December 21, 2004
Last modified:	October 13, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)