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Protein

ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

NAXD

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Miscellaneous

This protein may be expected to contain an N-terminal transit peptide but none has been predicted.UniRule annotation

Catalytic activityi

ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH.UniRule annotation
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH.

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei135NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei257NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi228 – 232ATPUniRule annotation5
Nucleotide bindingi247 – 256ATPUniRule annotation10

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.93UniRule annotation)
Alternative name(s):
ATP-dependent NAD(P)HX dehydrataseUniRule annotation
Carbohydrate kinase domain-containing proteinUniRule annotation
NAD(P)HX dehydrataseBy similarity
Gene namesi
Name:NAXDBy similarity
Synonyms:CARKDUniRule annotation
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003370231 – 329ATP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphotyrosineBy similarity1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5R824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 326YjeF C-terminalUniRule annotationAdd BLAST292

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni188 – 194NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000163126
HOVERGENiHBG057182
InParanoidiQ5R824
KOiK17757

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5R824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGPRYGAI RACGRVLERA FSLRKAHSIK DMENTLQLVR NIIPPLSSTK
60 70 80 90 100
HKGQDGRIGV VGGCQEYTGA PYFAAISALK VGADLSHVFC ASAAAPVIKA
110 120 130 140 150
YSPELIVHPV LDSRSAVHEA EKWLPRLHAL VVGPGLGRDD ALLRNVQGIL
160 170 180 190 200
EASKARDIPV VIDADGLWLV AQQPALIQGY RKAVLTPNHM EFSRLYDAVL
210 220 230 240 250
RGPMDSNDSH GSVLRLSQAL GNVTVVQKGE RDILSNGQQV LVCSQEGSSR
260 270 280 290 300
RCGGQGDLLS GSLGVLVHWA LLAGPEKTNG SSPLLVAAFG ACSLTRQCNH
310 320
QAFQKHGRST TTSDMIAEVG AAFSKLFET
Length:329
Mass (Da):35,099
Last modified:December 21, 2004 - v1
Checksum:i4721AA59995B0AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859931 mRNA Translation: CAH92086.1
RefSeqiNP_001126217.1, NM_001132745.1

Genome annotation databases

GeneIDi100173186
KEGGipon:100173186

Similar proteinsi

Entry informationi

Entry nameiNNRD_PONAB
AccessioniPrimary (citable) accession number: Q5R824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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