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Protein

Adhesion G protein-coupled receptor B2

Gene

ADGRB2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT signaling pathway probably via a G-protein dependent pathway. Might be involved in angiogenesis inhibition.By similarity

Enzyme regulationi

Displays increased activity following removal of N-terminal regions (mimicking the situation after proteolytic cleavage in the GPS domain and N-terminal fragment release).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor B2
Alternative name(s):
Brain-specific angiogenesis inhibitor 2
Gene namesi
Name:ADGRB2
Synonyms:BAI2
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 869ExtracellularCuratedAdd BLAST849
Transmembranei870 – 890Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini891 – 898CytoplasmicCurated8
Transmembranei899 – 919Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini920 – 927ExtracellularCurated8
Transmembranei928 – 948Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini949 – 969CytoplasmicCuratedAdd BLAST21
Transmembranei970 – 990Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini991 – 1011ExtracellularCuratedAdd BLAST21
Transmembranei1012 – 1032Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1033 – 1053CytoplasmicCuratedAdd BLAST21
Transmembranei1054 – 1074Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1075 – 1080ExtracellularCurated6
Transmembranei1081 – 1101Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1102 – 1485CytoplasmicCuratedAdd BLAST384

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000024561421 – 1485Adhesion G protein-coupled receptor B2Add BLAST1465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi309 ↔ 344PROSITE-ProRule annotation
Disulfide bondi313 ↔ 349PROSITE-ProRule annotation
Disulfide bondi324 ↔ 334PROSITE-ProRule annotation
Disulfide bondi364 ↔ 399PROSITE-ProRule annotation
Disulfide bondi368 ↔ 404PROSITE-ProRule annotation
Glycosylationi370N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi379 ↔ 389PROSITE-ProRule annotation
Disulfide bondi420 ↔ 455PROSITE-ProRule annotation
Disulfide bondi424 ↔ 460PROSITE-ProRule annotation
Disulfide bondi435 ↔ 445PROSITE-ProRule annotation
Disulfide bondi467 ↔ 502PROSITE-ProRule annotation
Disulfide bondi490 ↔ 520PROSITE-ProRule annotation
Glycosylationi493N-linked (GlcNAc...)Sequence analysis1
Glycosylationi578N-linked (GlcNAc...)Sequence analysis1
Glycosylationi800N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi807 ↔ 839PROSITE-ProRule annotation
Disulfide bondi827 ↔ 841PROSITE-ProRule annotation
Modified residuei1251PhosphotyrosineBy similarity1

Post-translational modificationi

Proteolytically cleaved at 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment.By similarity
Glycosylated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei284 – 285Cleavage; by furinBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with GABPB2. Interacts (via carboxy-terminus) with TAX1BP3.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5R7Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini297 – 350TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini352 – 405TSP type-1 2PROSITE-ProRule annotationAdd BLAST54
Domaini408 – 461TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini463 – 516TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini804 – 856GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi117 – 122Poly-Glu6
Compositional biasi177 – 180Poly-Asn4
Compositional biasi1215 – 1218Poly-Pro4
Compositional biasi1264 – 1270Poly-Gly7
Compositional biasi1325 – 1330Poly-Pro6

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 4 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004813.
InParanoidiQ5R7Y0.
KOiK04597.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 3 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 3 hits.
PROSITEiPS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5R7Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPACPLLLS VILSLRLAAA FDPAPSACSA LASGVLYGAF SLQDLFPTIA
60 70 80 90 100
SGCSWTLENP DPTKYSLYLR FNRQEQVCAH FAPRLLPLDH YLVNFTCLRP
110 120 130 140 150
SPEEAVTQAE SEVGRPEEEE AEAAAGLELC SGAGPFTFLH FDKNFVQLCL
160 170 180 190 200
SAEPSEAPRL LAPAALAFRF VEVLLINNNN SSQFTCGVLC RWSEECGRAA
210 220 230 240 250
GRACGFAQPG CSCPGEAGAG SATTTSPGPP AAHTLSNALV PGGPAPPAEA
260 270 280 290 300
DLHSGSSNDL FTTEMRYGEE PEEEPKVKTQ WPRSADEPGL YMAQTVHGVW
310 320 330 340 350
EEWGSWSLCS RSCGRGSRSR MRTCVPPQHG GKACEGPELQ TKLCSMAACP
360 370 380 390 400
VEGQWLEWGP WGPCSTSCAN GTQQRSRKCS VAGPAWATCT GALTDTRECS
410 420 430 440 450
NLECPATDSK WGPWNAWSLC SKTCDTGWQR RFRMCQATGT QGYPCEGTGE
460 470 480 490 500
EVKPCSEKRC PAFHEMCRDE YVMLMTWKKA AAGEIIYNKC PPNASGSASR
510 520 530 540 550
RCLLSAQGVA YWGLPSFARC ISHEYRYLYL SLREHLAKGQ RMLAGEGMSQ
560 570 580 590 600
VVRSLQELLA RRTYYSGDLL FSVDILRNVT DTFKRATYVP SADDVQRFFQ
610 620 630 640 650
VVSFMVDAEN KEKWDDAQQV SPGSVHLLRV VEDFIHLVGD ALKAFQSSLI
660 670 680 690 700
VTDNLVISIQ REPVSAVSSD ITFPMRGRRG MKDWVRHSED RLFLPKEVLS
710 720 730 740 750
LSSPGKPATS GAAGSPGRGR GPGTVPPGPG HSHQRLLPAD PDESSYFVIG
760 770 780 790 800
AVLYRTLGLI LPPPRPPLAV ASRVMTVTVR PPTQPPAEPL ITVELSYIIN
810 820 830 840 850
GTTDPHCASW DYSRADASSG DWDTENCQTL ETQAAHTRCQ CQHLSTFAVL
860 870 880 890 900
AQPPKDLTLE LAGSPSVPLV IGCAVSCMAL LTLLAIYAAF WRFVKSERSI
910 920 930 940 950
ILLNFCLSIL ASNILILVGQ SRVLSKGVCT MTAAFLHFFF LSSFCWVLTE
960 970 980 990 1000
AWQSYLAVIG RMRTRLVRKR FLCLGWGLPA LVVAVSVGFT RTKGYGTSSY
1010 1020 1030 1040 1050
CWLSLEGGLL YAFVGPAAVI VLVNMLIGII VFNKLMARDG ISDKSKKQRA
1060 1070 1080 1090 1100
GASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA
1110 1120 1130 1140 1150
VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA
1160 1170 1180 1190 1200
CQTVLFKEVN TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG
1210 1220 1230 1240 1250
NILVPMAASP GLGEPPPPQE ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD
1260 1270 1280 1290 1300
YMVLPRRTLS LQPGGGGGGG EDAPRARPEG TPRRAAKTVA HTEGYPSFLS
1310 1320 1330 1340 1350
VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE RSRTMPRTVP
1360 1370 1380 1390 1400
GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR HSELYHELNQ KFHTFDRYRS
1410 1420 1430 1440 1450
QSTAKREKRW SVSSGGAAER SVCADKPSPG ERPSLSQHRR HQSWSTFKSM
1460 1470 1480
TLGSLPPKPR ERLTLHRAAA WEPTEPPDGD FQTEV
Length:1,485
Mass (Da):162,022
Last modified:July 11, 2006 - v2
Checksum:i3FCE3D9B8197C278
GO

Sequence cautioni

The sequence CAH92130 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859978 mRNA. Translation: CAH92130.1. Different initiation.
RefSeqiNP_001126245.1. NM_001132773.1.

Genome annotation databases

GeneIDi100173216.
KEGGipon:100173216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR859978 mRNA. Translation: CAH92130.1. Different initiation.
RefSeqiNP_001126245.1. NM_001132773.1.

3D structure databases

ProteinModelPortaliQ5R7Y0.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiP02.029.
GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100173216.
KEGGipon:100173216.

Organism-specific databases

CTDi576.

Phylogenomic databases

HOVERGENiHBG004813.
InParanoidiQ5R7Y0.
KOiK04597.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 3 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 3 hits.
PROSITEiPS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRB2_PONAB
AccessioniPrimary (citable) accession number: Q5R7Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: November 30, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.